The Science of CanXida A Safer Candida Solution for Seniors

1. THE SCIENCE OF CANXIDA: A SAFER CANDIDA SOLUTION FOR SENIORS WH I T E PA PE R www.c a n x i d a .co m

2. WH I T E PA PE R : CA N XI DA R E M OVE THE SCIENCE OF CANXIDA: A SAFER CANDIDA SOLUTION FOR SENIORS 2

3. THE SCIENCE OF CANXIDA: A SAFER CANDIDA SOLUTION FOR SENIORS I N T R O D U CT I O N The Candida genus of fungi are opportunistic pathogens that colonize various sites in our bodies but can overgrow and become pathogenic under certain conditions. The most prominent disease-causing Candida species is Candida albicans, which is known for its invasivity and adaptability¹. Candida overgrowth can lead to various diseases, from cutaneous infection to deep-seated organ infection and even sepsis²–4. Candida-associated diseases can emerge at all ages but are particularly prevalent in seniors due to their increased likelihood of possessing several risk factors, including prolonged antibiotic use, weakened immune systems, and comorbidities like diabetes5. The current clinical repertoire is effective in many cases but can lead to the emergence of drug-resistant strains and side effects6–8. CanXida offers a range of safe, all-natural formulations that are nutrient-rich, scientifically backed, easy to use, and trigger minimal side effects and drug interactions9–¹¹*. Thus, CanXida products are promising additions to the healthcare regimen for older people to meet their specific challenges and provide an option some may prefer to standard therapies. Care for seniors is not just about curing a disease but should consist of a holistic approach to care, factoring emotional and spiritual well-being during this particularly vulnerable stage of life. 3

4. THE SCIENCE OF CANXIDA: A SAFER CANDIDA SOLUTION FOR SENIORS U N D E R STA N D I N G CA N D I DA I N S E N I O R S Dealing with Candida for older adults is increasingly common and problematic¹. Senior populations are more likely to carry risk factors for Candida infection than other age groups and are also more likely to struggle with overcoming Candida-associated disease. Seniors are more likely to suffer from infections and take longer to overcome them¹². This means they are more likely to undergo a prolonged course of antibiotics, a risk factor for Candida overgrowth. Antibiotics deplete our natural reservoir of good bacteria, allowing harmful microbes like Candida to overpopulate our bodies¹³. Older people are more likely to have weakened or less functional immune systems due to treatments such as chemotherapy or as a direct result of aging¹4. This also offers an opportunity for Candida overgrowth. Prolonged hospitalization, especially with invasive procedures like dialysis, increases the chances of contracting a Candida infection. Indeed, some Candida species have become specialized in colonizing hospital equipment, and many drug-resistant fungal strains have emerged in the clinical setting¹5. Furthermore, harsh treatments can take a substantial toll on the bodies of older adults and can significantly diminish their quality of life¹6. Increased medication means higher chances of side effects and drug interactions. Thus, combatting Candida in older populations comes with many unique challenges. However, CanXida can help overcome these challenges by using all-natural, alternative, scientifically backed, safer approaches which may have fewer side effects than conventional medicines and can be easily integrated into a holistic care approach*. Indeed, older patients may opt for CanXida instead of conventional drugs because of its many benefits. CA N XI DA PR O D U CT OVE R VI EW CanXida provides three all-natural formulations whose ingredients are scientifically proven to slow the growth of and kill Candida, repopulate the gut with good microbes, and aid recovery and health by bolstering the immune system¹7. Many ingredients have anti-inflammatory properties, which help alleviate co-morbid symptoms and may prevent disease¹8. 4

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6. THE SCIENCE OF CANXIDA: A SAFER CANDIDA SOLUTION FOR SENIORS CANXIDA REMOVE CanXida Remove is a 12-ingredient formulation designed by clinician, offering a comprehensive, safe, and natural approach to eliminating harmful fungi, bacteria, and parasites from the body¹¹*. Its use of natural ingredients lowers the risk of side effects and drug interactions and is particularly beneficial for older adults who take multiple medications. CANXIDA RESTORE CanXida Restore is a safe, science-backed probiotic supplement that can promote gut health following Candida infections. CanXida Restore comprises six probiotic strains, seven digestive enzymes, and a time-release formula for optimal effectiveness¹0. CANXIDA REBUILD CanXida Rebuild counteracts nutrient deficiencies caused by Candida overgrowth in the gastrointestinal tract. CanXida Rebuild contains crucial nutrients like magnesium, vitamins B6, B2, A, C, D, E, and minerals such as zinc and iron, whose absorption can be impaired by Candida9,¹9,²0. BENEFITS OF CANXIDA COMPARED TO TRADITIONAL PHARMACEUTICAL TREATMENTS With its natural ingredients, CanXida’s clinician-formulated products present a lower risk of side effects and drug interactions, a crucial consideration in geriatric care*. CanXida meets the specific health needs of older adults, addressing nutrient deficiencies caused by Candida overgrowth while ensuring a robust safety profile and a viable therapeutic alternative for them to choose. The effectiveness of CanXida is grounded in its scientifically backed ingredients, making it a compelling alternative to traditional pharmaceuticals, especially in managing the delicate balance of holistic health in older patients. 6 6

7. THE SCIENCE OF CANXIDA: A SAFER CANDIDA SOLUTION FOR SENIORS S C I E N T I F I C B AC K I N G O F I N G R E D I E N TS CanXida’s ingredients are backed up by robust scientific literature. Furthermore, many CanXida ingredients have been used for centuries as effective natural remedies for various illnesses, which is a testament to their efficacy and safety. Thus, older patients may prefer CanXida as an alternative approach to address their particular challenges. CANXIDA REMOVE CanXida Remove ingredients can slow and kill Candida species responsible for over 90% of infections, including C. albicans, C. tropicalis, and C. krusei. It also combats over 800 harmful bacterial species and various parasites. Ingredients like Grapefruit Seed Extract (GSE), Berberine, Clove, Garlic, Caprylic Acid, and others have been chosen for their proven antifungal, antibacterial, and anti-parasitic effects. These components work synergistically to treat Candida overgrowth safely, alleviate symptoms, and restore healthy gut function with fewer side effects¹¹. CANXIDA RESTORE CanXida scientifically-backed array of six probiotic strains, including Lactobacillus acidophilus, Lactobacillus plantarum, and Bifidobacterium bifidum, and seven targeted digestive enzymes. This formulation is engineered to optimize gut microbiome ecology post-antifungal interventions, addressing Candida-associated dysbiosis. These probiotics exert their therapeutic effect by altering gut pH, producing antimicrobial metabolites, and enhancing mucosal barrier integrity, thereby inhibiting pathogenic yeast and bacterial growth. The inclusion of digestive enzymes, such as amylase and protease, complements the probiotic action by facilitating nutrient breakdown and absorption¹0, helping senior patients gain renewed vitality, and facilitating holistic care and recovery. Restore leverages decades of microbiological research, integrating a CANXIDA REBUILD CanXida Rebuild contains safe, scientifically validated ingredients like Vitamin A (critical for T-cell function and epithelial integrity), Vitamin C (essential for neutrophil function and collagen synthesis), Vitamin D (regulator of immune response), and a spectrum of B vitamins crucial for metabolic processes and immune cell differentiation. Minerals such as iron (vital for various immune cells), magnesium (necessary for enzymatic reactions), and zinc (integral to immune system mediation) are also included. Selenium, copper, manganese, chromium, molybdenum, potassium, boron, and vanadium are also important in immune cell physiology and cytokine production and are present in this formulation9. Thus, CanXida Rebuild provides full coverage of essential vitamins and minerals for optimal immune health²¹–²³. 6 7

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9. THE SCIENCE OF CANXIDA: A SAFER CANDIDA SOLUTION FOR SENIORS S A F E TY PR O F I L E CANXIDA REMOVE CanXida’s all-natural ingredients are generally well tolerated and do not cause side effects but may cause interaction issues in certain contexts. GSE may affect drug metabolism due to its impact on cytochrome P450 enzymes²4,²5. Berberine can interact with blood thinners and diabetes medications²6,²7. Clove and Garlic, while generally safe, can cause gastrointestinal irritation and interact with certain drugs²8. Black Walnut Hull Extract, Oregano Oil, and Pau D’arco could interact with blood thinners²9,³0. Neem has liver and kidney risks at high doses and affects diabetes medications³¹. Biotin is generally safe but can interfere with certain lab tests³². CANXIDA RESTORE Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, and Lactobacillus rhamnosus, along with Bifidobacterium bifidum and Bifidobacterium longum, are probiotics that are generally considered safe and beneficial for gut health³³. Amylase, Cellulase, Glucoamylase, Hemicellulase, Invertase, Protease, and Serratiopeptidase are digestive enzymes that break down carbohydrates, proteins, and fibers, promoting better digestion and nutrient absorption. While these science-backed ingredients are generally safe for most people and may be preferred by older patients, specific health conditions or certain medications may necessitate further consultation. CANXIDA REBUILD Essential vitamins and minerals are typically well absorbed and tolerated as they are required for normal physiological function, making them a perfect part of holistic health regimens. Extreme overdose or accumulation of these micronutrients due to specific health conditions can cause health issues, however. Careful management of vitamin supplementation is essential in older adults as they are susceptible to deficiencies but may be prone to toxic vitamin accumulation³4,³5. Individuals with specific health conditions or those taking certain medications should consult a healthcare provider before use. 9

10. THE SCIENCE OF CANXIDA: A SAFER CANDIDA SOLUTION FOR SENIORS B E N E F I TS FO R O L D E R A D U LTS CanXida is an ideal holistic natural health supplement for older patients. Its gentle, science-based formulation caters to sensitive digestive systems and a low risk of drug interactions, which is crucial for seniors on multiple medications. CanXida’s ease of digestion and absorption also addresses the declining digestive efficiency in older age³6. Our products support immune function, commonly weakened in seniors¹4, and include probiotic elements to maintain healthy gut flora³³*. Additionally, CanXida’s anti-inflammatory properties³7,³8 and nutrient-rich composition, supplying essential vitamins and minerals like Vitamin D, B vitamins, calcium, and magnesium, are particularly beneficial for seniors9. CanXida also boosts energy and vitality, addressing common fatigue issues in older adults. Designed for easy administration and reduced risk of side effects, CanXida considers the potential challenges older people face, such as difficulty swallowing pills or complex dosing schedules³9. Our formulations are tailored to address other common senior health concerns, including poor circulation, blood sugar regulation, and heart health, making it a comprehensive and thoughtful choice for elder care and one they may choose if given the opportunity*. 1 0

11. THE SCIENCE OF CANXIDA: A SAFER CANDIDA SOLUTION FOR SENIORS T E ST I M O N I A LS F R O M O U R C U STO M E R S ( OVE R 6 0 S ) I saw results after 4 to 4 1/2 months! Huge impact on my health!! Cleared up my symptoms, even my itchy ears, jaw clenching, headaches!... I used RMV, RST, and RBD. I love this company!! It has changed my life for the better!! L I N DA R . I used CanXida Remove for one month along with a strict Candida diet…I saw results after one month. The ebooks, videos, and recipes are fantastic. I feel I have a good guide. Just need to stay with it. D OVE G . You can find our YouTube channel here. E A S E O F U S E A N D CO M PL I A N C E Senior patients may experience difficulty administering or sticking with a treatment regimen³9. This can occur for a variety of reasons. For instance, many older people experience difficulty swallowing, which can rule out many options and lead to nutrient deficiency40. Furthermore, specific treatments can have side effects that are more pronounced in older adults or are only associated with certain age-associated comorbidities4¹. Contraindications are more prevalent in older populations, narrowing possible treatment regimens. Comorbidities that affect motor or cognitive function can also lead to reduced compliance4². For instance, memory loss is common in older adults, as well as conditions like Alzheimer’s and Parkinson’s disease4³. Thus, a supplement that is safe, easy to take, and can enhance an existing holistic health regimen is essential. All of CanXida’s products come in easy-to-use tablet formulations that can be taken alongside other medications with reduced risk of drug interactions*. 1 1

12. THE SCIENCE OF CANXIDA: A SAFER CANDIDA SOLUTION FOR SENIORS This means senior patients are more likely to successfully self-administer CanXida products and may prefer it over other options. Our customers have reported minimal discomfort when taking our products. This is a distinct advantage of CanXida over other types of medications, which can cause severe discomfort, especially in patients with gastrointestinal issues. Furthermore, CanXida’s natural products come in slow-release formulations, which means the active evidence-based ingredients are introduced to the body slowly, potentially reducing the chances of discomfort or nausea. CO M PA R AT IVE A N A LYS I S The current repertoire of antifungal therapies used to treat Candida and related diseases is associated with several side effects, resistance concerns, and higher costs. Amphotericin B is commonly used in the clinic but can cause nephrotoxicity44. 5-fluorocytosine (5-FC) works by inhibiting fungal DNA synthesis and is used commonly in combination with other drugs, but resistance to 5-FC is widespread among many fungal species, limiting its clinical utility45,46. A newer class of antifungals called azoles has largely replaced 5-FC and similar drugs but are also prone to rapid resistance development45. Terbinafine is an enduringly valuable antifungal and is generally the first port of call for cutaneous dermatophyte infections. However, Candida species resistant to terbinafine have emerged6,7. By comparison, CanXida contains safe, all-natural ingredients with broad, scientifically verified mechanisms of action. This means that while conventional therapies are prone to resistance, CanXida is less likely to yield antifungal resistance and has reduced potential for drug interactions. CanXida is also cheaper than conventional therapies and available without a prescription. Furthermore, our more gentle formulations make CanXida products less irritating to the digestive system. Thus, they may be the preferred choice for older patients with sensitive digestive systems who prefer a holistic approach over narrow pharmaceutical approaches. The slow-release formula means our ingredients are introduced gradually into the body, and our clients have told us that CanXida did not come with the side effects they had experienced with other medications and therapies. Doctor visits and consultations with naturopaths greatly exceed the cost of CanXida, in terms of money and time. Our package and wholesale deals make CanXida a great alternative to care, especially for patients with limited resources*. 1 2

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14. THE SCIENCE OF CANXIDA: A SAFER CANDIDA SOLUTION FOR SENIORS I N T EG R AT I O N I N TO H O L I ST I C CA R E PL A N S CanXida's safe selection of products perfectly complements any holistic care plan. Holistic approaches consider our emotional, mental, and spiritual health in addition to physical health47. Senior patients may opt for holistic care plans using natural products like CanXida instead of conventional therapies. CanXida can help improve multiple dimensions of patients' lives with simple solutions. Older adults may experience nausea or chronic gut inflammation because of their illness and treatment regimen. These individuals are more likely to have a diminished capacity for nutrient absorption from their food. CanXida’s products may solve digestive issues with minimal side effects and medication interactions. CanXida Restore contains six scientifically-backed probiotics and digestive enzymes that help with the digestion of food¹0. Being active and able to engage in hobbies is crucial for older patients, especially those suffering from potentially debilitating diseases. CanXida’s Rebuild formulation can help boost vitality and energy levels in older adults, allowing them to lead as normally as possible through treatment and recovery. Certain medications, such as antibiotics, can lead to candidiasis overgrowth. CanXida’s products can complement these medications by helping prevent Candida's overgrowth and potentially protecting the patient from downstream complications. Thus, CanXida products can reduce many symptoms that can lessen the holistic wellness of older patients. R EG U L ATO RY CO M PL I A N C E A N D STA N DA R D S The facility where CanXida products are manufactured is GMP (Good Manufacturing Practices) certified by the National Sanitation Foundation (NSF), Food and Drug Administration (FDA)-registered, and is a member of the National Products Association (NPA). CanXida’s products and ingredients undergo multiple rounds of testing and quality analysis to ensure they are safe and effective for our clients. Our ingredients are screened for heavy metals like arsenic and lead, harmful microbes like E. coli and yeasts, and for their potency and purity, ensuring no contaminant-drug interaction, which may be particularly dangerous for older adults. CanXida’s individual ingredients and complete formulations receive certificates of analysis from the manufacturer before they are sold, meaning they are safe and will perform as intended. At CanXida, we go the extra mile for our clients and send our science-based products for independent third-party testing to ensure their quality. We consider our client’s holistic health and ensure high manufacturing standards help remove doubts and anxieties many patients can experience when dealing with disease. This may make CanXida an option older patients will choose over conventional medicines. To sum up, CanXida adheres to the highest production and regulatory compliance standards to bring safe, all-natural remedies to our clients with minimal side effects and zero risk of contamination. 1 4

15. THE SCIENCE OF CANXIDA: A SAFER CANDIDA SOLUTION FOR SENIORS FAQ s FO R H E A LT H CA R E PR O F E S S I O N A LS WHO DESIGNED THE CANXIDA FORMULATIONS? CanXida’s formulations were designed by a clinician with thirty years of experience working with patients dealing with Candida-associated issues. This experience included working with older adults and taking their unique medical challenges and treatment preferences into consideration at all stages of care and recovery, ensuring holistic well-being. CAN CANXIDA SUPPLEMENT NUTRITIONAL DEFICIENCIES? CanXida Rebuild contains a huge range of essential vitamins and minerals that can help to cover nutritional deficiencies without introducing harmful drug interactions. These micronutrients are required for a functional immune system and can reduce the chances of developing further infections or other morbidities while Candida-related issues are resolved9. WHY SHOULD I CHOOSE CANXIDA OVER CHEAPER ALTERNATIVES? We performed a comparison analysis of our products to competitors and found that none of them contained even close to the coverage of CanXida’s products. Thus, CanXida is a great recommendation for patients seeking a comprehensive, safe, all-natural alternative pathway to holistic health. WHICH PROBIOTICS DOES CANXIDA RESTORE CONTAIN? CanXida Restore contains Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus rhamnosus, Bifidobacterium bifidum, and Bifidobacterium longum. All have been scientifically shown to promote gut health while providing reduced side effects. CanXida Restore also contains digestive enzymes that help to restore and maintain digestive function often compromised in older adults¹0. WHAT NATURAL ANTI-CANDIDA INGREDIENTS DOES CANXIDA REMOVE CONTAIN? CanXida Remove contains twelve natural ingredients used as traditional medicines for centuries. Important ingredients include garlic, which contains the powerful antimicrobial ingredient allicin. Grapefruit seed extract is another potent ingredient that has proven activity against the most common pathogenic Candida species, including Candida albicans¹¹. 1 5

16. THE SCIENCE OF CANXIDA: A SAFER CANDIDA SOLUTION FOR SENIORS C LO S I N G S U M M A RY Candida-related illnesses are a significant concern for older adults due to their increased vulnerability to risk factors such as prolonged antibiotic use, weakened immune systems, and comorbidities. CanXida's three all-natural formulations - CanXida Remove, CanXida Restore, and CanXida Rebuild - offer a safe way to promote holistic health as a standalone or complement to other medicines¹7. CanXida Remove effectively targets harmful fungi, bacteria, and parasites, reducing the risk of drug interactions and side effects, which is particularly crucial for older adults, often on multiple medications¹¹*. CanXida Restore promotes gut health through probiotics and digestive enzymes, addressing Candida-associated dysbiosis¹0. CanXida Rebuild counters nutrient deficiencies caused by Candida overgrowth, ensuring essential vitamins and minerals are replenished in a demographic where digestive issues and poor nutrient absorption are common9. CanXida’s ingredients are typically well-tolerated. However, given the potential for drug interactions, older patients need to consult healthcare professionals before use. CanXida offers ease of use and compliance with tablet formulations that can be taken alongside other medications. The slow-release formulations reduce the chances of discomfort, enhancing patient adherence. Comparatively, traditional antifungal medications often come with severe side effects, resistance concerns, and higher costs, making CanXida a promising option. CanXida products offer solutions to digestive issues, boost energy levels, and complement conventional medications, ultimately enhancing the holistic wellness of senior patients. CanXida adheres to rigorous quality control measures and regulatory standards, ensuring safety and efficacy. Overall, CanXida is a natural, holistic, and scientifically-backed solution for managing Candida-related issues in older adults, addressing the unique challenges faced by this vulnerable demographic*. CanXida offers a perfect solution for geriatricians looking to recommend a product to an older patient who prefers natural remedies. If you are interested in learning more about CanXida, contact us today. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 1 6

17. WHITE PAPER: THE SCIENCE OF CANXIDA: A SAFER CANDIDA SOLUTION FOR SENIORS R E F E R E N C E S 1. Lopes JP, Lionakis MS. Pathogenesis and virulence of Candida albicans. Virulence. 2022;13(1):89-121. doi:10.1080/21505594.2021.2019950 2. Cavalheiro M, Teixeira MC. Candida Biofilms: Threats, Challenges, and Promising Strategies. Front Med. 2018;5:28. doi:10.3389/fmed.2018.00028 3. Kühbacher A, Burger-Kentischer A, Rupp S. Interaction of Candida Species with the Skin. Microorganisms. 2017;5(2):32. doi:10.3390/microorganisms5020032 4. Peroumal D, Sahu SR, Kumari P, Utkalaja BG, Acharya N. Commensal Fungus Candida albicans Maintains a Long-Term Mutualistic Relationship with the Host To Modulate Gut Microbiota and Metabolism. Alanio A, ed. Microbiol Spectr. 2022;10(5):e02462-22. doi:10.1128/spectrum.02462-22 5. Paillaud E, Merlier I, Dupeyron C, Scherman E, Poupon J, Bories PN. Oral candidiasis and nutritional deficiencies in elderly hospitalised patients. Br J Nutr. 2004;92(5):861-867. doi:10.1079/BJN20041264 6. Hu Y, Hu Y, Lu Y, et al. A case report of penile infection caused by fluconazole-and terbinafine-resistant Candida albicans. Mycopathologia. 2017;182:397-402. 7. Sharafutdinov IS, Ozhegov GD, Sabirova AE, et al. Increasing Susceptibility of Drug-Resistant Candida albicans to Fluconazole and Terbinafine by 2(5H)-Furanone Derivative. Molecules. 2020;25(3):642. doi:10.3390/molecules25030642 8. Ademe M, Girma F. Candida auris: From Multidrug Resistance to Pan-Resistant Strains. Infect Drug Resist. 2020;13:1287-1294. doi:10.2147/IDR.S249864 9. CanXida. CanXida Rebuild Whitepaper. https://candida.yeastinfection.org/wp-content/uploads/2022/customer-files/canxida_rebuild_whitepaper.pdf 10. CanXida. CanXida Restore Whitepaper. https://candida.yeastinfection.org/wp-content/uploads/2022/customer-files/canxida_restore_whitepaper.pdf 11. CanXida. CanXida Remove White Paper. https://candida.yeastinfection.org/wp-content/uploads/2022/customer-files/canxida_remove_whitepaper.pdf 12. Esme M, Topeli A, Yavuz BB, Akova M. Infections in the Elderly Critically-Ill Patients. Front Med. 2019;6:118. doi:10.3389/fmed.2019.00118 13. Drummond RA, Desai JV, Ricotta EE, et al. Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria. Cell Host Microbe. 2022;30(7):1020-1033.e6. doi:10.1016/j.chom.2022.04.013 14. Weyand CM, Goronzy JJ. Aging of the Immune System. Mechanisms and Therapeutic Targets. Ann Am Thorac Soc. 2016;13 Suppl 5(Suppl 5):S422-S428. doi:10.1513/AnnalsATS.201602-095AW 15. Nobile CJ, Johnson AD. Candida albicans Biofilms and Human Disease. Annu Rev Microbiol. 2015;69(1):71-92. doi:10.1146/annurev-micro-091014-104330 16. Lavan AH, Gallagher P. Predicting risk of adverse drug reactions in older adults. Ther Adv Drug Saf. 2016;7(1):11-22. doi:10.1177/2042098615615472 17. How CanXida Supports Gut Health: Balancing the Gut Microbiome – CanXida’s Role in Candida Management | CanXida Blog. Accessed December 15, 2023. https://blog.canxida.com/how-canxida-supports-gut-health/ 18. Furman D, Campisi J, Verdin E, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25(12):1822-1832. doi:10.1038/s41591-019-0675-0 19. Almeida RS, Wilson D, Hube B. Candida albicans iron acquisition within the host. FEMS Yeast Res. 2009;9(7):1000-1012. doi:10.1111/j.1567-1364.2009.00570.x 20. Citiulo F, Jacobsen ID, Miramón P, et al. Candida albicans Scavenges Host Zinc via Pra1 during Endothelial Invasion. Mitchell AP, ed. PLoS Pathog. 2012;8(6):e1002777. doi:10.1371/journal.ppat.1002777

18. WHITE PAPER: THE SCIENCE OF CANXIDA: A SAFER CANDIDA SOLUTION FOR SENIORS 21. Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients. 2020;12(1):236. doi:10.3390/nu12010236 22. Peterson CT, Rodionov DA, Osterman AL, Peterson SN. B Vitamins and Their Role in Immune Regulation and Cancer. Nutrients. 2020;12(11):3380. doi:10.3390/nu12113380 23. Mitra S, Paul S, Roy S, et al. Exploring the Immune-Boosting Functions of Vitamins and Minerals as Nutritional Food Bioactive Compounds: A Comprehensive Review. Mol Basel Switz. 2022;27(2):555. doi:10.3390/molecules27020555 24. Bailey DG, Dresser G, Arnold JMO. Grapefruit-medication interactions: forbidden fruit or avoidable consequences? CMAJ Can Med Assoc J J Assoc Medicale Can. 2013;185(4):309-316. doi:10.1503/cmaj.120951 25. Brandin H, Myrberg O, Rundlöf T, Arvidsson AK, Brenning G. Adverse effects by artificial grapefruit seed extract products in patients on warfarin therapy. Eur J Clin Pharmacol. 2007;63(6):565-570. doi:10.1007/s00228-007-0289-1 26. Wang X, Zhang Y, Yang Y, Wu X, Fan H, Qiao Y. Identification of berberine as a direct thrombin inhibitor from traditional Chinese medicine through structural, functional and binding studies. Sci Rep. 2017;7:44040. doi:10.1038/srep44040 27. Pang B, Zhao LH, Zhou Q, et al. Application of berberine on treating type 2 diabetes mellitus. Int J Endocrinol. 2015;2015:905749. doi:10.1155/2015/905749 28. Mateen AA, Rani PU, Naidu MUR, Chandrashekar E. Pharmacodynamic interaction study of Allium sativum (garlic) with cilostazol in patients with type II diabetes mellitus. Indian J Pharmacol. 2011;43(3):270-274. doi:10.4103/0253-7613.81514 29. Amirou A, Razzok EM, Legssyer A, et al. Effects of Walnut Bark Extract on the Human Platelet Aggregation, Adhesion, and Plasmatic Coagulation In Vitro. Adv Pharmacol Pharm Sci. 2023;2023:5644803. doi:10.1155/2023/5644803 30. Abebe W. Review of herbal medications with the potential to cause bleeding: dental implications, and risk prediction and prevention avenues. EPMA J. 2019;10(1):51-64. doi:10.1007/s13167-018-0158-2 31. Bhaskar MV, Pramod SJ, Jeevika MU, Chandan PK, Shetteppa G. MR imaging findings of neem oil poisoning. AJNR Am J Neuroradiol. 2010;31(7):E60-61. doi:10.3174/ajnr.A2146 32. Rosner I, Rogers E, Maddrey A, Goldberg DM. Clinically Significant Lab Errors due to Vitamin B7 (Biotin) Supplementation: A Case Report Following a Recent FDA Warning. Cureus. 2019;11(8):e5470. doi:10.7759/cureus.5470 33. Shi LH, Balakrishnan K, Thiagarajah K, Mohd Ismail NI, Yin OS. Beneficial Properties of Probiotics. Trop Life Sci Res. 2016;27(2):73-90. doi:10.21315/tlsr2016.27.2.6 34. Thurman JE, Mooradian AD. Vitamin Supplementation Therapy in the Elderly: Drugs Aging. 1997;11(6):433-449. doi:10.2165/00002512-199711060-00003 35. Kaur D, Rasane P, Singh J, et al. Nutritional Interventions for Elderly and Considerations for the Development of Geriatric Foods. Curr Aging Sci. 2019;12(1):15-27. doi:10.2174/1874609812666190521110548 36. Rémond D, Shahar DR, Gille D, et al. Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition. Oncotarget. 2015;6(16):13858-13898. doi:10.18632/oncotarget.4030 37. Mahmoud DA, Hassanein NM, Youssef KA, Abou Zeid MA. Antifungal activity of different neem leaf extracts and the nimonol against some important human pathogens. Braz J Microbiol Publ Braz Soc Microbiol. 2011;42(3):1007-1016. doi:10.1590/S1517-838220110003000021 38. Verma G, Sharma V. A Scientific Update on Juglans Regia Linn. Asian J Pharm Res Dev. 2020;8(3):166-175. doi:10.22270/ajprd.v8i3.741 39. Punnapurath S, Vijayakumar P, Platty PL, Krishna S, Thomas T. A study of medication compliance in geriatric patients with chronic illness. J Fam Med Prim Care. 2021;10(4):1644-1648. doi:10.4103/jfmpc.jfmpc_1302_20 40. Crary M, Sura L, Madhavan A, Carnaby-Mann G. Dysphagia in the elderly: management and nutritional considerations. Clin Interv Aging. Published online July 2012:287. doi:10.2147/CIA.S23404

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