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Description Winstrol 50Mg Stanozolol, which is manufactured under the brand and trade name Winstrol is available as both an injectable and oral anabolic steroid. It is commonly seen as the third most popular anabolic steroid used among athletes and bodybuilders alike. Dianabol takes the number one spot, while Deca-Durabolin takes the second spot. Winstrol gained approval for use in treating a multitude of medical issues after being released as a prescription medication. These ranged from treating muscle wasting diseases, stunted growth in children, treating burns victims and for treating osteoporosis. However, when used for treating anaemia it proved not to be as successful. Winstrol also possesses a reduced affinity when it comes becoming bound with glucocorticoid binding sites. It also has a lower degree of progestogenic activity while offering activities independent of the androgen receptor. The Properties of Winstrol Various studies have shown that the primary mechanism of action of Winstrol is its action of binding with cellular androgen receptors instead of an activity that is not receptor mediated. Winstrol is also thought to have a tiny measurable form of properties that are anti progestogenic when it comes to the progesterone receptor. It also has a reduced affinity for interactions with the glucocorticoid binding site, along with activity independent of the glucocorticoid, progesterone and androgen receptors. No notable progestogenic activity has been found to be caused by using Winstrol. Winstrol has a high affinity for binding with the sex hormone-binding globulin (SHBG). Therefore, much more of the anabolic steroid is made available in the bloodstream, thus sending signals for muscle growth to begin. Sex hormone-binding globulin is a protein that works by binding and attaching to the other sex hormones found in the body, such as synthetic anabolic steroids,
estrogen and testosterone. Once the protein has attached to the sex hormones, it renders them as useless for the entire time that it is bound to them. It prevents sex hormones from doing their job. However, Winstrol has shown its ability to suppress the production of SHBG within the body while preventing it from being able to bind with anabolic steroids. As an example, one study where orally administered Winstrol was given to 25 male subjects, SHBG levels dropped by 48.4% in just 3 days. An important note to make is that, unlike nearly all other anabolic steroids, both oral and injectable Winstrol preparations have exactly the same chemical structure. The majority of other anabolic steroids have injectable preparations that have been esterified to help modulate the half-life and release rate while oral anabolic steroids will always be C-17 Alpha alkylated. This does present a slight need for concern as an increase in liver toxicity can be experienced with either preparation due to them being 100% identical. However, the first pass through the liver is avoided with injectable Winstrol. Therefore, it is considered to present a reduced hepatotoxic effect on the liver than the orally administered Winstrol. Regardless of that fact, it is still hepatotoxic and the duration that it is used four should be limited. Side Effects Associated With Winstrol When looking at the main side effects that the individual should be concerned about when using Winstrol, please include hepatic issues, negative cardiovascular system issues, and hpta disruption. As we have already touched upon, Winstrol is unable to be aromatized into estrogen, regardless of the dosing. Therefore, side effects associated with estrogen including bloating, high blood pressure, water retention and gynecomastia have zero risks of presenting themselves. While it is true that the androgenic strength rating of Winstrol is far less than that of testosterone, side effects are still a possibility, nonetheless. Typically, those with androgen sensitivity are most likely to be affected. Androgenic side effects include an increased risk of male pattern baldness to those predisposed to the condition. An increase in acne and oily skin. increased facial and body hair growth. And an increased risk of benign prostatic hypertrophy. Many people think that using a 5 Alpha-reductase inhibitor such as Propecia, Proscar, dutasteride or finasteride will help mitigate the side effects. However, they will be ineffective for reducing side effects due to the fact that Winstrol does not convert into dihydrotestosterone. One area that raises concerns is Winstrol ability for suppression of HPTA. Of course, all anabolic steroids will present with this, and Winstrol was shown to decrease the production of endogenous testosterone by 55% with a dosage of just 10 milligrams a day over a period of 14 days. Another fact that the individual should be aware of is the hepatotoxic effect it has on the liver, especially the oral form of Winstrol. The hepatotoxic effect on the liver was also shown with the injectable form of Winstrol. Therefore, the duration of use should be moderated and limited for no longer than 6 weeks to 8 weeks at any given time. Winstrol also poses detrimental side effects related to cardiovascular health. It is well known for its negative and dangerous alteration of cholesterol levels in the blood, even a tiny 6 mg doses using an oral variant. This is also true with the injectable variant of Winstrol. Evidence also suggests that even small doses of Winstrol are able to stimulate cardiac hypertrophy.