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Carbonic anhydrases

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jul 2008] CAIX is a transmembrane protein structurally consisting of a signal peptide, a proteoglycan-related region, a CA domain with a highly conserved active site, a transmembrane anchor and an intracytoplasmic tail, and is the only tumor-associated CA isoenzyme known so far. Compared with normal tissues, CAIX is overexpressed in a wide spectrum of tumor types and associated with increased metastasis and poor prognosis in aggressive carcinomas. CAIX expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. CA9 is regarded as a new therapeutic target for CA9-derived carcinomas.

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Carbonic anhydrases

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  1. CA9 Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jul 2008] CAIX is a transmembrane protein structurally consisting of a signal peptide, a proteoglycan-related region, a CA domain with a highly conserved active site, a transmembrane anchor and an intracytoplasmic tail, and is the only tumor-associated CA isoenzyme known so far. Compared with normal tissues, CAIX is overexpressed in a wide spectrum of tumor types and associated with increased metastasis and poor prognosis in aggressive carcinomas. CAIX expression is

  2. cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. CA9 is regarded as a new therapeutic target for CA9-derived carcinomas. SynonymsCA9; carbonic anhydrase IX; MN; CAIX; carbonic anhydrase 9; pMW1; CA-IX; P54/58N; membrane antigen MN; carbonic dehydratase; carbonate dehydratase IX; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250; MN/CA9 Recombinant Proteins Cell & Tissue Lysates Cat.# Product name Source (Host) Species Tag Price CA9-1544CARecombinant Canine CA9 protein, Fc-tagged, APC labeled HEK293 Canine Fc +Inquiry CA9-1544CPRecombinant Canine CA9 protein, Fc-tagged, R-PE labeled HEK293 Canine Fc +Inquiry CA9-890HA Recombinant Human CA9 protein, Fc-tagged, APC labeled HEK293 Human Fc +Inquiry CA9-890HP Recombinant Human CA9 protein, Fc-tagged, R-PE labeled HEK293 Human Fc +Inquiry CA9-0250H Recombinant Human CA9 Protein, GST-Tagged Wheat Germ Human GST +Inquiry

  3. CA9-2272H Recombinant Human CA9 Protein, MYC/DDK-tagged HEK293 Human MYC/DDK +Inquiry CA9-1544C Recombinant Canine CA9 Protein, Fc-tagged HEK293 Canine Fc +Inquiry CA9-10627H Recombinant Human CA9 protein, GST-taggedE. coli Human GST +Inquiry CA9-256H Recombinant Human CA9, His tagged HEK293 Human His+Inquiry CA9-27269TH Recombinant Human CA9 Wheat germ Human +Inquiry CA9-7844H Recombinant Human CA9 protein, His-tagged E. coli Human His+Inquiry CA9-890H Recombinant Human CA9, Fc tagged HEK293 Human Fc +Inquiry Car9-914M Recombinant Mouse Car9, His tagged HEK293 Mouse His+Inquiry CA9-1039C Recombinant Canine CA9 Protein, His-tagged HEK293 Canine His+Inquiry Involved Pathway CA9 involved in several pathways and played different roles in them. We selected most pathways CA9 participated on our site, such as Nitrogen metabolism, which may be useful for your

  4. reference. Also, other proteins which involved in the same pathway with CA9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway NamePathway Related Protein Nitrogen metabolismCA6; Car12; CAR6; CA4; Car9; CA12; CAR1; Car4; CAR15; CAHZ Protein Function CA9 has several biochemical functions, for example, carbonate dehydratase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA9 itself. We selected most functions CA9 had, and list some proteins which have the same functions with CA9. You can find most of the proteins on our site. FunctionRelated Protein Function carbonate dehydratase activityRelated Protein Car12; CAR3; CA2; CA13; Car8; CA5A; Car4; CA5; CA9; CA12 Function zinc ion bindingRelated Protein BTR09; ADAMTSL3; SUV39H1A; TNP2; RNF121; TNKS; MARCH5; TRIM59; MAN2A2; MKRN1 CA9 Related Articles Kato, Y; Hagiwara, M; et al. TNF-alpha augmented Porphyromonas gingivalis invasion in human gingival epithelial cells through Rab5

  5. and ICAM-1. BMC MICROBIOLOGY 14:-(2014). Fujihara, R; Usui, M; et al. Tumor necrosis factor-alpha enhances RANKL expression in gingival epithelial cells via protein kinase A signaling. JOURNAL OF PERIODONTAL RESEARCH 49:508-517(2014).

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