1 / 6

Metabolism of nucleotides

Metabolism of nucleotides. Richard Vytášek 2011. Introduction. Structure of nucleobases, nucleosides and nucleotides Metabolic functions effected by nucleotides Dietetary uptake of nucleotides and their utilization. Biosynthesis of nucleotides.

Antony
Download Presentation

Metabolism of nucleotides

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Metabolism of nucleotides Richard Vytášek 2011

  2. Introduction • Structure of nucleobases, nucleosides and nucleotides • Metabolic functions effected by nucleotides • Dietetary uptake of nucleotides and their utilization

  3. Biosynthesis of nucleotides • Biosynthesis of purine nucleotides de novo (PRPP -> IMP -> AMP, GMP) and its regulation • Purine salvage pathway (Lesch-Nyhan Syndrom) • Biosynthesis of pyrimidine nucleotides de novo and its regulation • Pyrimidine salvage pathway • Biosynthesis of deoxyribonucleotides • Biosynthesis of thymine nucleotides

  4. Catabolism of nucleotides and nucleobases • Degradation of nucleotides • Degradation of purine nucleotides • Gout • Degradation of pyrimidine nucleotides • Degradation of thymine

  5. Nucleoside analogues • antiviral agents (typically inhibitors of reverse transcriptase – e.g. azidothymidine ) • cytostatics (chemotherapy – e.g. cytosine arabinoside )

  6. Literature Harper´s Illustrated Biochemistry (2006) pp. 294-310

More Related