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Role for Hypocretin in Mediating Stress-Induced Reinstatement of Cocaine-Seeking Behavior

Hypocretin-1 and -2 (Hcrt-1

Antony
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Role for Hypocretin in Mediating Stress-Induced Reinstatement of Cocaine-Seeking Behavior

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    1. Role for Hypocretin in Mediating Stress-Induced Reinstatement of Cocaine-Seeking Behavior Investigating the effects of Hypocretin-1+2 (Hcrt-1 / Hcrt-2)? on reinstatement of drug seeking behavior through stress pathways

    2. Hypocretin-1 and -2 (Hcrt-1 & -2)? Recently discovered Lateral Hypothalmic Neuropeptides (1996) also known as Orexins 1+2 bind equally at Hcrt-R Projections Locus Ceruleus (Major) - NE Dorsal Raphe Nuclei - 5-HT Amygdala Suprachiasmatic Nucleus – biological clock Basal Forebrain Cholinergic Brainstem Spinal Cord

    3. Hypocretin Evidence points to excitatory function ?energy expenditure, ?feeding behavior, ?locomotor activity. Evidence indicates that Hcrt neurons drive hyper-arousal through modulation of stress Stress? ?CRF? ?Hypocretin Role for Hcrt in reward seeking?

    4. Hypocretin (background) Foot shock (FS) and Restraint (RS) induce c-Fos expression in Hypocretin neurons Less so in neurons with CRF-R knockouts

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