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il6r

his gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

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il6r

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  1. il6r il6r Official Full Name Official Full Name interleukin 6 receptor Background Background his gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9. Synonyms Synonyms IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1; interleukin 6 receptor; IL6R Recombinant Recombinant Proteins Proteins  Cell & Tissue Lysates Cell & Tissue Lysates Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price IL6R- 1058H Recombinant Human IL-6 Protein E.coli Human +Inquiry IL6R- 457R Recombinant Rhesus IL6R Protein, His- tagged HEK293 Rhesus His +Inquiry

  2. Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price IL6R- 787H Recombinant Human IL6R Protein, His- Avi-tagged, Biotinylated HEK293 Human His-Avi +Inquiry IL6R- 2176H Recombinant Human IL6R Protein, MYC/DDK-tagged HEK293 Human MYC/DDK +Inquiry IL6R- 5174H Recombinant Human IL6R Protein, GST- tagged Wheat Germ Human GST +Inquiry IL6R- 5175H Recombinant Human IL6R Protein Wheat Germ Human +Inquiry IL6R- 056R Recombinant Rat IL6R Protein, Fc- tagged HEK293 Rat Fc +Inquiry IL6R- 100H Recombinant Human Interleukin-6 Soluble Receptor,His- tagged E. coli Human His +Inquiry IL6R- 200H Recombinant Human IL6R, CHO Human Fc +Inquiry

  3. Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price MIgG2a Fc- tagged IL6R- 201H Recombinant Human IL6R, HIgG1 Fc- tagged CHO Human Fc +Inquiry IL6R- 239H Recombinant Human IL6R, C13&N15- labeled HEK293 Human N/A +Inquiry IL6R- 29271TH Recombinant Human IL6R Human +Inquiry IL6R- 322H Recombinant Human IL6R, Fc-tagged CHO Human Fc +Inquiry IL6R- 428H Recombinant Human IL6R, His-tagged NSO cells Human His +Inquiry IL6R- 584H Recombinant Human Interleukin 6 Receptor Baculovirus- Insect Cells Human N/A +Inquiry IL6R- 786H Recombinant Human IL6R, His tagged HEK293 Human His +Inquiry

  4. Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price IL6R- 964H Recombinant Human Interleukin 6 Receptor E. coli Human N/A +Inquiry Il6r- 1145R Recombinant Rat Il6r Protein, His- tagged HEK293 Rat His +Inquiry Il6r- 1836R Recombinant Rat Il6r protein, His- tagged E. coli Rat His +Inquiry Il6r- 9168H Recombinant Rat Il6r, His- tagged HEK293 Rat His +Inquiry Il6r- 935R Recombinant Rat Il6r, His- tagged HEK293 Rat His +Inquiry IL6R- 1559R Recombinant Rhesus Monkey IL6R Protein HEK293 Rhesus monkey +Inquiry IL6R- 1560R Recombinant Rhesus Monkey IL6R Protein, hIgG1-tagged HEK293 Rhesus monkey hIgG1 +Inquiry

  5. Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price IL6R- 1561R Recombinant Rhesus Monkey IL6R Protein, hIgG4-tagged HEK293 Rhesus monkey hIgG4 +Inquiry IL6R- 1064C Recombinant Canine IL6R Protein, His- tagged HEK293 Canine His +Inquiry IL6R- 6383Z Recombinant Zebrafish IL6R Mammalian Cells Zebrafish His +Inquiry IL6R- 9166H Recombinant Cynomolgus IL6R, His- tagged HEK293 Macaca mulatta His +Inquiry IL6R- 545H Recombinant Human Interleukin 6 Receptor HEK293 Human N/A +Inquiry IL6R- 1241H Recombinant Human Interleukin 6 Receptor, His- tagged E. coli Human His +Inquiry IL6R- 1242H Recombinant Human Interleukin 6 Receptor E. coli Human N/A +Inquiry

  6. Involved Pathway IL6R involved in several pathways and played different roles in them. We selected most pathways IL6R participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, PIK- Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL6R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway Name Pathway Name Pathway Related Protein Pathway Related Protein Cytokine-cytokine receptor interaction CXCL5; CCL19; IL3; CCL20B; CCL21B; TNF; XCL1; Flt3l; CSF1R; CXCL16 HIF- signaling pathway TIMP1; PRKCA; ANGPT1; ANGPT4; TCEB1; SLC2A1; PLCG2; PLCG1; INSR; RPS6KB1 PIK-Akt signaling pathway FGF4; PHLPP1; LAMB3; PIK3CA; GNG2; PHLPP2; ITGA6; TCL1B; TLR2; MTOR Jak-STAT signaling pathway IL15; RNF207B; LEPB; CCND2A; TYK2; SOCS6B; IL23R; GRB2A; IFNK; MYCB Hematopoietic cell lineage CD34; IL1B; GP1BA; GP9; CD4; HLA-DRA; KITLG; GM13305; CSF3; ITGA6 Non-alcoholic fatty liver disease (NAFLD) NDUFV3; NDUFA4L2; CASP8; PIK3CB; NDUFC2-KCTD14; COX8C; CDC42; NDUFA7; COX7B; UQCRFS1 Protein Function IL6R has several biochemical functions, for example, ciliary neurotrophic factor binding, contributes_to ciliary neurotrophic factor receptor activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL6R itself. We selected most functions IL6R had, and list some proteins which have the same functions with IL6R. You can find most of the proteins on our site. Funct Function ion Related Protein Related Protein Function Function ciliary neurotrophic factor binding Related Protein Related Protein Il6ra; IL6R Function Function contributes_to ciliary neurotrophic factor receptor activity Related Protein Related Protein IL6R; Il6ra; LIFR; CNTFR Function Function enzyme binding

  7. Related Protein Related Protein SCNM1; PHKG2; CYP2A4; PIAS1; APP; IQCB1; EHHADH; PCCA; PLCB1; PPP1R3D Function Function interleukin-6 binding Related Protein Related Protein IL6R; Il6ra Function Function contributes_to interleukin-6 receptor activity Related Protein Related Protein IL6ST; IL6R; Il6ra Function Function contributes_to interleukin-6 receptor binding Related Protein Related Protein IL6R; IL6; IL6ST; Il6ra Function Function protein binding Related Protein Related Protein BCDIN3D; PDZK1; ZNHIT6; ZCCHC8; CLNK; LYRM2; ID4; TRIM35; ASNS; Anks6 Function Function protein homodimerization activity Related Protein Related Protein PVRL1; CADM1A; RELA; GPD1L; BCL2A1A; NLGN4X; BOKB; ASGR1; TERF2; PTS Interacting Protein IL6R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL6R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL6R. IL6; K2; JAK1; ERAP1; Adam17; IL6ST IL6R Related Articles Tseng-Rogenski, SS; Hamaya, Y; et al. Interleukin 6 Alters Localization of hMSH3, Leading to DNA Mismatch Repair Defects in Colorectal Cancer Cells. GASTROENTEROLOGY 148:579-589(2015). Kim, G; Ouzounova, M; et al. SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model. ONCOGENE 34:671-680(2015). IL6R Related Gene Family

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