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MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosinbinding protein C is a myosin-associated protein found in the crossbridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMPdependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] <br>
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mybpc3 mybpc3 Official Full Name Official Full Name myosin binding protein C, cardiac Background Background MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin- binding protein C is a myosin-associated protein found in the cross- bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP- dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] Synonyms Synonyms MYBPC3; myosin binding protein C, cardiac; FHC; CMH4; CMD1MM; LVNC10; MYBP-C; myosin-binding protein C, cardiac-type; C-protein, cardiac muscle isoform; Recombinant Recombinant Proteins Proteins Product Product name name Source Source (Host) (Host) Cat.# Cat.# Species Species Tag Tag Price Price MYBPC3- 1289H Recombinant Human MYBPC3 Protein, His-SUMO- tagged E. coli Human His- SUMO +Inquiry MYBPC3- 1125H Recombinant Human MYBPC3, His-tagged E. coli Human His +Inquiry
Product Product name name Source Source (Host) (Host) Cat.# Cat.# Species Species Tag Tag Price Price MYBPC3-19H Recombinant HEK293 Human MYC/DDK +Inquiry Human MYBPC3 protein, MYC/DDK- tagged MYBPC3- 501H Recombinant Human MYBPC3 Mammalian Cells Human His +Inquiry MYBPC3- 8230H Recombinant Human MYBPC3 protein, His & GST- tagged E. coli Human His/GST +Inquiry MYBPC3- 3836R Recombinant Rat MYBPC3 Protein Mammalian Cells Rat His +Inquiry MYBPC3- 6673C Recombinant Chicken MYBPC3 Mammalian Cells Chicken His +Inquiry MYBPC3- 3886Z Recombinant Zebrafish MYBPC3 Mammalian Cells Zebrafish His +Inquiry Involved Pathway MYBPC3 involved in several pathways and played different roles in them. We selected most pathways MYBPC3 participated on our site, such as Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), Muscle
contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYBPC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway Name Pathway Name Pathway Related Protein Pathway Related Protein Dilated cardiomyopathy DES; TPM4; ADRB1; TNNI3; EMD; CACNG8; ITGA9; ITGA2B; GNAS; Itga10&Itgb1 Hypertrophic cardiomyopathy (HCM) TNNC1; ITGB7; ITGA5; ACTG1; CACNA2D1; SGCB; SGCG; TTN; ITGA2; PRKAB1 Muscle contraction MYBPC1; TMOD1; TNNT3A; MYL6B; MYBPC2; DMD; MYBPC2B; TMOD4; ANXA6; TNNI2A.4 Striated Muscle Contraction DESMA; DESMB; MYBPC2A; TNNI2B.2; ACTA1B; ACTA1; TNNT1; TCAP; TMOD3; TMEM8C Protein Function MYBPC3 has several biochemical functions, for example, ATPase activator activity, actin binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYBPC3 itself. We selected most functions MYBPC3 had, and list some proteins which have the same functions with MYBPC3. You can find most of the proteins on our site. Function Function Related Protein Related Protein Function Function ATPase activator activity Related Protein Related Protein DNAJC24; MYBPC3; TOR1AIP1; DNAJC19; DNAJC15; DNAJC10; DNAJB6; ATP1B3; TOR1AIP2; RAB4A Function Function actin binding Related Protein Related Protein DSTN; FLNC; MYH6; SMYHC1; MYH10; ACTN3B; HIP1; SYN1; TNNI3; DAG1 Function Function identical protein binding Related Protein Related Protein MICALL1; OAT; PAK2; TPRGL; TRP63; HCFC1; KHDC1B; TPCN2; PRPF3; IMPA1 Function Function metal ion binding Related Protein Related Protein ARSF; TREX1; CALUA; ZBTB7C; NEURL1AA; ARMC1L; QTRT1; PXDN; RNASEH2A; PLA2G2F Function Function myosin binding Related Protein Related Protein ARFGEF1; CALM; FXYD1; ARFGEF2; TRIM32; VETZ; ACTA1; CALD1B; SMYD1B; KIRREL Function Function myosin heavy chain binding
Related Protein Related Protein MYBPC3; CORO1A; AMPD1; MYL2; MYL12B; PDLIM2; MYL9 Function Function protein binding Related Protein Related Protein LRP1; SEPT6; CALM3; SFRP5; PRKDC; PSMB1; RANBP2; NOP56; TUBGCP2; SLC25A5 Function Function structural constituent of muscle Related Protein Related Protein MYBPC3; TPM2; TTN; ANKRD2; ACTN3; PLEC; TCAP; MYOM1; MYL5; DAG1 Function Function titin binding Related Protein Related Protein ANKRD2; ANKRD1; TRIM63; CAPN3; ACTN2; CALM2; SLC14A2; MYBPC3; CAMK2D; CALM1 Interacting Protein MYBPC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYBPC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYBPC3. PDE4DIP; SVIL; MYZAP; CNN1; ACTB; ACTC1; FLNC; TNNI3K; SPATA20; PARD3; TRIM63; CCT7; SMURF2
