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neurotrophic tyrosine kinase, receptor, type 1

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.

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neurotrophic tyrosine kinase, receptor, type 1

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  1. ntrk1 ntrk1 Official Full Name Official Full Name neurotrophic tyrosine kinase, receptor, type 1 Background Background This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008] Synonyms Synonyms NTRK1; neurotrophic tyrosine kinase, receptor, type 1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; high affinity nerve growth factor receptor; gp140trk; Oncogene TRK; tyrosine kinase receptor A; tropomyosin-related kinase A; TRK1-transforming tyrosine kinase protein Recombinant Recombinant Proteins Proteins  Cell & Tissue Lysates Cell & Tissue Lysates Assay Kits Assay Kits Cat.# Cat.# Product name Product name Source (Host) Source (Host) Species Species Tag Tag Price Price NTRK1- 2030H Recombinant Human NTRK1 Protein, Fc/His-tagged HEK293 Human Fc/His +Inquiry NTRK1- 509R Recombinant Rabbit NTRK1 Protein, His-tagged HEK293 Rabbit His +Inquiry NTRK1- 108H Recombinant Human NTRK1, Fc Chimera HEK293 Human Fc +Inquiry

  2. Cat.# Cat.# Product name Product name Source (Host) Source (Host) Species Species Tag Tag Price Price NTRK1- 448H Recombinant Human NTRK1, GST-tagged, Active Sf 9 Insect cells Human GST +Inquiry Ntrk1- 589R Recombinant Rat TrkA, FC Chimera NS0 Rat Fc +Inquiry NTRK1- 155H Recombinant Human NTRK1, Fc-His tagged HEK293 Human FC/His +Inquiry NTRK1- 156H Recombinant Human NTRK1, His tagged HEK293 Human His +Inquiry NTRK1- 166H Recombinant Human NTRK1, Fc Chimera NSO cells Human Fc Chimera +Inquiry NTRK1- 296H Recombinant Human NTRK1 Protein, DDK/His-tagged HEK293 Human DDK/His +Inquiry NTRK1- 297H Recombinant Human NTRK1 Protein, DDK/His-tagged HEK293 Human DDK/His +Inquiry NTRK1- 31618TH Recombinant Human NTRK1 Human +Inquiry NTRK1- 31619TH Recombinant Human NTRK1, Fc-tagged Human Fc +Inquiry NTRK1- 717H Recombinant Human NTRK1, GST-His Sf 9 Insect cells Human GST +Inquiry NTRK1- 86H Recombinant Human NTRK1 protein, Flag-tagged, Biotinylated Insect cell Human Flag +Inquiry

  3. Cat.# Cat.# Product name Product name Source (Host) Source (Host) Species Species Tag Tag Price Price NTRK1- 973H Recombinant Human NTRK1, His tagged E. coli Human His +Inquiry NTRK1- 977H Recombinant Human NTRK1, His tagged HEK293 Human His +Inquiry NTRK1- 415M Recombinant Mouse Ntrk1, His tagged HEK293 Mouse His +Inquiry NTRK1- 476M Recombinant Mouse Ntrk1, Fc tagged HEK293 Mouse His +Inquiry NTRK1- 4102R Recombinant Rat NTRK1 Protein Mammalian Cells Rat His +Inquiry Ntrk1- 44R Recombinant Rat Ntrk1, Fc tagged HEK293 Rat His +Inquiry Ntrk1- 45R Recombinant Rat Ntrk1, His tagged HEK293 Rat His +Inquiry NTRK1- 295C Recombinant Canine NTRK1, His tagged HEK293 Canine His +Inquiry NTRK1- 296C Recombinant Canine NTRK1, Fc tagged HEK293 Canine FC/His +Inquiry NTRK1- 6930C Recombinant Chicken NTRK1 Mammalian Cells Chicken His +Inquiry NTRK1- 8470Z Recombinant Zebrafish NTRK1 Mammalian Cells Zebrafish His +Inquiry

  4. Cat.# Cat.# Product name Product name Source (Host) Source (Host) Species Species Tag Tag Price Price NTRK1- 495H Recombinant Human NTRK1, Fc-tagged NS0 Human Fc +Inquiry Involved Pathway NTRK1 involved in several pathways and played different roles in them. We selected most pathways NTRK1 participated on our site, such as MAPK signaling pathway, Endocytosis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with NTRK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway Name Pathway Name Pathway Related Protein Pathway Related Protein MAPK signaling pathway CACNG7; CACNB3; TAOK2; MAPK10; HSC70; PDGFA; IKBKB; RPS6KA3; CACNG7A; RPS6KA1 Endocytosis DNM2A; CYTH4; CHMP2A; TGFB1; PARD6GB; PARD6B; ACAP2; CBL; ADRB3A; ARPC5A Apoptosis GZMF; DIABLOB; VIML; DFFB; AKT1; CAPN2; DFFA; Fasl; CASP7; LMNB1 Neurotrophin signaling pathway CAMK4; TP53; SORT1; RPS6KA2; SHC4; CDC42; CAMK2G; ZFP110; TRP53; BRAF Inflammatory mediator regulation of TRP channels PPP1CC; HTR2C; PRKCQ; BDKRB1; PLCB1; PLA2G4A; NTRK1; CYP2C54; CYP2C38; CALM2 Pathways in cancer GNG12; PTCH2; EGLN1; PIK3CG; Casp3; FGF4; STAT5B; TRAF6; PLCB4; SMAD2 Transcriptional misregulation in cancer LDB1; RELA; BCL2L1; LMO2; H3F3C; CCNA1; FCGR1; BIRC3; FLI1; CCNT2 Thyroid cancer NCOA4; TCF7L2; RET; TCF7; HRAS; NTRK1; CCND1; LEF1; MAP2K2; CDH1 Central carbon metabolism in cancer PIK3CB; SCO2; SLC7A5; NTRK3; PFKP; PGAM2; FLT3; PGAM1; TP53; HIF1A Protein Function NTRK1 has several biochemical functions, for example, ATP binding, ephrin receptor binding, kinase binding. Some of the functions are

  5. cooperated with other proteins, some of the functions could acted by NTRK1 itself. We selected most functions NTRK1 had, and list some proteins which have the same functions with NTRK1. You can find most of the proteins on our site. Function Function Related Protein Related Protein Function Function ATP binding Related Protein Related Protein CMPK2; MAPK10; PNCK; EPHB2; ACTR8; DARS; CMPK; HSPA1B; ATAD5B; TTLL10 Function Function ephrin receptor binding Related Protein Related Protein EFNA1A; EFNA5B; Anks1; EPHA4; SHC1; EPHA7; EFNB2; PIK3CG; EFNA3; EFNB3B Function Function kinase binding Related Protein Related Protein RB1; WWC1; SRC; WWC3; STRADA; CEBPB; PARP16; PARK2; SP100; ATF5 Function Function nerve growth factor binding Related Protein Related Protein SORT1; NGFRB; FURIN; NGFR; PCSK6; NTRK1 Function Function NOT nerve growth factor binding Related Protein Related Protein NTRK1 Function Function nerve growth factor receptor activity Related Protein Related Protein NTRK1; SORT1 Function Function neurotrophin binding Related Protein Related Protein NGFR; NTRK1; NTRK3; NTRK2 Function Function neurotrophin p75 receptor binding Related Protein Related Protein NTRK1; NTF3; ZFP110; NRADD Function Function protein binding Related Protein Related Protein FAT4; IGFBP7; WDYHV1; CDCA7L; KDM6B; WAS; THY1; REG3A; GTSE1; GADD45B Function Function protein homodimerization activity Related Protein Related Protein PCYT1A; IL6ST; ATF3; GRPEL1; TCF3; KLRB1B; FASN; SPPL3; GSTM7; SNX1 Function Function transmembrane receptor protein tyrosine kinase activity Related Protein Related Protein ERBB3A; IGF1RB; NTRK1; NTRK3; AXL; EPHB4; DDR1; IGF1RA; EGFRA; NTRK3A Interacting Protein NTRK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NTRK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NTRK1. NGF; NGF; Pirb; PLCG1; PIK3R1; SHC1; SORT1; PTPRC; PTPN1

  6. NTRK1 Related Articles Pajtler, KW; Mahlow, E; et al. Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells. ONCOTARGET 5:11180-11192(2014). Youssef, G; Gillett, C; et al. Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: A potential novel prognostic marker for breast cancer. MODERN PATHOLOGY 27:361-374(2014).

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