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spam1

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement;membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3;and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol;SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme;located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that;enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that;plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida;adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes;leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for;this gene.

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  1. spam1 spam1 Official Full Name Official Full Name sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) Background Background Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement;membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3;and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol;SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme;located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that;enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that;plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida;adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes;leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for;this gene. Synonyms Synonyms SPAM1; sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); sperm adhesion molecule 1; HYA1; HYAL PH-20; HYAL PH20; Hyal- PH20; HYAL1; HYAL3; HYAL5; HYALP_HUMAN; Hyaluronidase PH-20; Hyaluronoglucosaminidase PH-20; MGC26532; PH-20 Hyaluronidase; PH20; PH20 Hyaluronidase; SPAG15; SPAM-1; Sperm surface protein PH-20; Sperm surface protein PH20; zona pellucida binding; hyaluronidase, zona pellucida binding; PH-20 Recombinant Recombinant Proteins Proteins  Cell & Tissue Lysates Cell & Tissue Lysates

  2. Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price TNFSF11- 313H Recombinant Human Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding), His- Fc-Tagged CHO Human FC/His +Inquiry SPAM1- 1532H Recombinant Human SPAM1, His-Fc-tagged CHO Human His/Fc +Inquiry SPAM1- 738H Recombinant Human SPAM1, His-tagged HEK293 Human His +Inquiry SPAM1- P1004H Recombinant Human SPAM1 protein CHO Human +Inquiry SPAM1- 15816M Recombinant Mouse SPAM1 Protein Mammalian Cells Mouse His +Inquiry SPAM1- 5682R Recombinant Rat SPAM1 Protein Mammalian Cells Rat His +Inquiry SPAM1- 358B Recombinant Bovine SPAM1, His-tagged CHO cells Bovine His +Inquiry

  3. Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price SPAM1- 5156Z Recombinant Zebrafish SPAM1 Mammalian Cells Zebrafish His +Inquiry Involved Pathway SPAM1 involved in several pathways and played different roles in them. We selected most pathways SPAM1 participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway Name Pathway Name Pathway Related Protein Pathway Related Protein Glycosaminoglycan degradation HPSE; HYAL3; SPAM1; SGSH; ARSB; GNSB; HYAL2; GLB1; HPSE2; HYAL1 Metabolic pathways ALDH7A1; ACSL3; NADK; IDS; ZNRD1; UGDH; ALDH1A1; ST3GAL3; PLA2G1B; ADSSL Protein Function SPAM1 has several biochemical functions, for example, hyalurononglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPAM1 itself. We selected most functions SPAM1 had, and list some proteins which have the same functions with SPAM1. You can find most of the proteins on our site. Function Function Related Protein Related Protein Function Function hyalurononglucosaminidase activity Related Protein Related Protein HYAL3; HYAL2; HYAL4; MGEA5; HYAL1; CD44; HYAL6; KIAA1199; SPAM1 Interacting Protein SPAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two

  4. hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPAM1. hyaluronan SPAM1 Related Articles Blondeau, JJC; Deng, M; et al. Identification of novel long non- coding RNAs in clear cell renal cell carcinoma. CLINICAL EPIGENETICS 7:-(2015). Yoon, S; Chang, KT; et al. Characterization of pig sperm hyaluronidase and improvement of the digestibility of cumulus cell mass by recombinant pSPAM1 hyaluronidase in an in vitro fertilization assay. ANIMAL REPRODUCTION SCIENCE 150:107-114(2014).

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