2021 Most Authoritative Sex-enhancing Drugs Guide For Treating Erectile Dysfunct

1. JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED www.cmoapi.com 2021 Most Authoritative Sex-enhancing Drugs Guide For Treating Erectile Dysfunction (ED) Erectile dysfunction has been a concern for men since the beginning of written history. Treatments for ED date back to as early as the eighth century, when men of Ancient Rome and Greece wore talismans of rooster and goat genitalia. Believe it can serve as an aphrodisiac and promote sexual function. By the end of the 18th century, sheep testis extract was injected as a source of testosterone to correct impotence. In 1970s, penile implants had made a name for themselves as a solution for erectile dysfunction. At the same time, penile vacuum pumps were gaining popularity and Geddings Osbon’s “youth equivalence device” (or YED) was paving the way for the penis vacuum devices that we are familiar with to this day. The 1980s laid the groundwork for a sexual revolution with the research of Dr. Giles Brindley. Brindley injected a vasodilator into his veins, which caused corporal smooth muscle relaxation and induced an erection. His discovery led to research on vasodilators and alpha-blocking agents as a treatment for erectile dysfunction. The major breakthrough occurred In the early 1990s, sildenafil was approved as a heart medication, and it was discovered that men taking the medication were experiencing firmer, longer-lasting erections. This led to further research on sildenafil as an erectile drug, and Pfizer unveiled Viagra in 1998. Sildenafil became the first oral drug to be approved to treat ED. Treatment of erectile dysfunction was revolutionized with the discovery of sildenafil or Viagra. This was followed by the use of tadalafil and vardenafil as similar phosphodiesterase-5 inhibitor oral medications for treating ED in 2003. For many men, life has never been better. Erectile Dysfunction (ED) is a common male medical condition, study survey demonstrated that ED is increasingly prevalent with age: approximately 40% of men are affected at age 40 and nearly 70% of men are affected at age 70. The prevalence of complete ED increased from 5% at age 40 to 15% at age 70.2 Age was the variable most strongly associated with ED. A decrease in sexual desire with increasing age. Men in the oldest cohort (50 to 59) were more than 3 times as likely to experience erection problems and to report low sexual desire compared with men 18 to 29. Experience of sexual dysfunction was more likely among men in poor physical and emotional health. In the pass few decades, there has been a significant increase in our understanding of the physiologic mechanisms responsible for erectile dysfunction(ED). Erectile dysfunction(ED) has become a topic of considerable media and societal interest and acceptance. Paralleling the increase in knowledge has been an explosion in therapeutic options. info@cmoapi.com

2. JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED www.cmoapi.com Erectile dysfunction or disorde(ED), also called impotence, is the inability to develop and maintain an erection for satisfactory sexual intercourse or activity. Most often when blood flow in the penis is limited or nerves are harmed. It’s often caused by an underlying health problem, like: stress, tiredness, anxiety etc.You can try to use drugs, solve the root cause, change your lifestyle and solve the psychosocial problems for treatments. If you’re looking for options to treat your ED, this article offers helpful information for people experiencing this problem, or those close to them. (1) Mechanics of erectile dysfunction (ED) This causes your penis to expand and stiffen when blood fills two chambers known as the corpora cavernosa, much like a balloon as it is filled with water. Impulses from the brain and genital nerves start the process. Anything that blocks these impulses or restricts blood flow to the penis can cause ED. (2) Symptoms/Signs of erectile dysfunction (ED) A man is considered to have ED when the following symptoms occur regularly: Trouble getting an erection Trouble having an erection Trouble keeping an erection for a long enough period of time Some sexual disorders are related to ED and may cause similar symptoms to ED, such as: Premature ejaculation (ejaculating too soon) The inability to have an orgasm after sufficient stimulation Delayed ejaculation (when ejaculation takes too long)right up arrow Low levels of the hormone testosterone Reduced libido or sex drive A dysfunction in the muscles of the pelvic floor Trauma to the pelvis, such as pelvic fractures Some studies have shown men with ED are at significant risk of getting a heart attack, stroke or circulatory problems in the legs. ED also causes: Low self-esteem Depression Distress for the man and his partner Speak with your doctor if you have any of these symptoms, especially if they’ve lasted for 3 or more months. They can help determine whether your symptoms are caused by an info@cmoapi.com

3. JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED www.cmoapi.com underlying condition that requires treatment. It aims to fix or enhance erectile function, help circulatory health and help the quality of a man's life (3) Difference between ED and poor sex drive Men may have several types of issues including poor sex drive and problems with ejaculation. But ED refers specifically to trouble getting or keeping an erection. You might have a healthy sex drive, but a body that won’t respond. Most of the time there is a physical basis for the problem. Men are involved in the process of erection through brain, hormones, emotions, nerves, muscles and blood vessels. Any of these problems may cause or contribute to ED. With age, the proportion of men with some ED symptoms will increase with the increase of life, but aging will not lead to ED. ED can be treated at any age. Lifestyle caused ED Lifestyle choices can contribute to ED, smoking, excessive drinking, and drug abuse can impair blood circulation and lead to erectile dysfunction. Being overweight and getting too little exercise also contribute to erectile dysfunction. Men who exercise regularly have a lower risk of erectile dysfunction. Psychological caused ED Good mood can help to wake up the brain, if you’re under stress, mental health conditions like depression or anxiety, your brain can have trouble creating nerve connections and releasing the hormones responsible for causing an erection. So psychological issues can be a significant contributing factor to erectile dysfunction. Chronic Disease caused ED The link between chronic disease and ED is most striking for diabetes. Men with diabetes are two to three times more likely to have erectile dysfunction. Any condition that affects the way blood flows through your body could lead to ED. This includes cardiovascular disease, atherosclerosis (hardening of the arteries), kidney disease, and multiple sclerosis. Medication caused ED Many medications can cause or contribute to erectile dysfunction, including blood pressure drugs, antidepressants, antihistamines, acid reflux medications, opioid pain medications. and tranquilizers. Talk to your doctor if you think a prescription or over-the-counter drug may be causing erectile problems. But never stop taking any medicine before you discuss it with your doctor. info@cmoapi.com

4. JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED www.cmoapi.com Surgery caused ED Surgical or radiation treatments for prostate cancer, bladder cancer, or prostate enlargement (BPH) can sometimes damage nerves and blood vessels near the penis. If the nerve damage is permanent, you’ll need treatment to get an erection. But sometimes surgery causes temporary ED that gets better on its own after 6 to 18 months. In most cases, if you’re appearing lack of interest or desire for sex, inability to be awakened, painful intercourse, you may be dealing with erectile dysfunction. Occasional, or intermittent, sexual problems don't necessarily point to erectile dysfunction. Erectile Dysfunction(ED) can affect men at different ages, but won't impact his quality of life. This article can help you to find a suitable treatment and help to support a fulfilling sex life and improve your erectile performance, make you feel back to your old self again. Medication For most men, they usually consider to take oral medications for erectile dysfunction(ED) treatment firstly, to help to get and maintain an erection. These men sex-enhancing oral drugs (PDE5 inhibitors) include tadalafil (Cialis), sildenafil (Viagra), vardenafil (Levitra, Staxyn) and avanafil (Stendra), through improve sexual function by relaxing smooth muscles and increasing blood flow to the penis. You should not take any of these drugs to treat erectile dysfunction(ED) if you are taking nitrates for heart disease. Testosterone therapy (TRT) may also be recommended if you have low levels of testosterone. Alprostadil (Caverject, Edex, MUSE) is another medication approved by FDA that can be used to treat erectile dysfunction(ED). It can be administered in two ways: as a penile suppository or as a self-injection at the base or side of the penis. Penile injection is the most effective type of ED treatment for men who can't take oral treatment. Mechanical Aids If medications aren't effective or appropriate, vacuum devices and penile implants etc other aids also can help men to achieve or maintain an erection. It is also approved for use in women, just be more expensive. Dilators may help women who experience narrowing of the vagina. Devices like vibrators can be helpful to help improve sexual enjoyment and climax. Alternative medicine There are certain alternative medicines and "dietary supplements" that claim to treat erectile dysfunction, like: Panax ginseng supplements, ginkgo, pomegranate juice, and yohimbe supplements etc. But not all “natural” medicines or supplements are safe.You info@cmoapi.com

5. JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED www.cmoapi.com should consult your doctor first before using any supplement, to make sure it have enough safe for treat ED. Psychotherapy Treated with a well-trained counselor can help you deal with past sexual trauma, anxiety, depression, stree, and poor body image. They can help you and your partner reconnect emotionally, which may also help your ED. Recommend Surgery For most men, surgery should be the last resort, through vascular surgery to correct some of the vascular causes of ED. The recovery time varies, but the success rate is high. Many anecdotal reports indicate that the following 4 sex-enhancing drugs are best effective to help men treat erectile dysfunction (ED). (1) Sildenafil Sildenafil is first oral drugs to be FDA approved for first-line treatment of erectile dysfunction (ED), it's a well known PDE5 inhibitor. Sildenafil works by increasing blood flow to the penis by relaxing blood vessels and smooth muscle to help a man get and keep an erection. Also, Sildenafil can be used in both men and women to treat pulmonary arterial hypertension, it works on the PDE5 enzyme in the lungs to relax the blood vessels, this increase the supply of blood to the lungs and reduce the workload of the heart. Sildenafil is more popular than comparable drugs, with generic and brand versions. Viagra & Revatio be sold to market under Sildenafil brand name, can be taken by mouth or injection into a vein, the dosage forms of sildenafil comes as a tablet and powder for suspension. Onset is typically within 20 minutes and can lasts for about 2 hours. For most patients to use sildenafil to treat erectile dysfunction(ED), the recommended sildenafil dosage is 50mg, as needed, take sildenafil at least 30 minutes before sexual activity, but no more than 4 hours,1 hour before is the most effective, do not take more than once per day. Based on effectiveness and toleration, sildenafil dose may be increased to a maximum recommended dose of sildenafil 100 mg or decreased to sildenafil 25 mg, it may be taken with or without food. But, a high-fat meal take together with sildenafil may delay how quickly the drug start to work. (2) Tadalafil Tadalafil belongs to a class of oral sex-enhancing drugs called phosphodiesterase (PDE) inhibitors, sold under the brand name Cialis and Adcirca, is used to treat erectile dysfunction(ED) and the symptoms of benign prostatic hypertrophy (BPH,enlarged info@cmoapi.com

6. JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED www.cmoapi.com prostate). Tadalafil works by increasing blood flow to the penis to help a man get and keep an erection. Sometimes, it's also used to treat pulmonary hypertension(PAH) (high blood pressure in the blood vessels that supply the lungs). Many anecdotal reports indicate that Tadalafil (Cialis) is the longest-lasting PDE5 drug for ED, it can last up to 36~72hours.There are two different ways if need to take tadalafil to treat erectile dysfunction, tadalafil is unaffected by food, it can be taken as every day or needed basis. If tadalafil take as daily, it may attempt sexual activity at any time between your doses, do not take tadalafil more often than once daily, the usual tadalafil dosage is 2.5 mg to 5 mg by mouth once a day. If tadalafil take it as needed, usually at least 30 minutes before sexual activity, the typical dose of tadalafil is 5 mg to 20 mg depend on response Cialis (tadalafil) and not more often than once every 24 hours. Tadalafil's effect on sexual ability may last up to 36~72 hours. When taking tadalafil on a regular schedule and miss dosage, take it as soon as you remember. If near the time to next dosage, skip the missed dosage, take next dosage at the regular time. Do not double the dose to catch up. Tadalafil need store at room temperature away from light and moisture, can't store in the bathroom, and keep all medications away from children and pets, it can only be taken by adults aged 18 and over. In addition, all medications may cause risks and benefits. Even if tadalafil is working, you may experience some unwanted tadalafil side effects, including: headache, stomach upset, back pain, muscle pain, stuffy nose, flushing, or dizziness etc. If these common side effects persist or worsen, please tell your doctor or pharmacist promptly. Rarely, if occurs vision changes or sudden vision loss(including permanent blindness, in one or both eyes)), prolonged erection lasting 4 or more hours, sudden decrease or loss of hearing, sometimes with ringing in the ears and dizziness, serious allergic reaction(rash, itching/swelling, severe dizziness, trouble breathing etc) and other serious side effects, stop taking tadalafil and get medical help right away. Meanwhile, Tadalafil(Cialis) oral tablets/capsule may interact with prescribed and over-the-counter medications, vitamins, and dietary or herbal supplement. To help avoid Tadalafil interactions, you need to find out how tadalafil might interact with something else you’re taking, and talk with your doctor or pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Always let your doctor and pharmacist about all your current medicines. (3) Vardenafil Hydrochloride Vardenafil, also known by the brand name Levitra or Staxyn, is a effective sex-enhancing drugs that treats male erectile dysfunction, it comes as a tablet and a rapidly disintegrating (dissolves in the mouth and is swallowed without water) tablet to be taken by mouth. Like other PDE5 medications for ED, vardenafil works by increasing blood flow to the penis. Vardenafil mechanism of action that is nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the info@cmoapi.com

7. JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED www.cmoapi.com smooth muscle cells of the corpus cavernosum. The cGMP triggers smooth muscle relaxation, increasing blood flow into the penis, resulting in erection. Vardenafil function is similar to sildenafil or Viagra, but Viagra lasts between 2 and 4 hours, while Vardenafil (Levitra) lasts 4 hours. However, vardenafil use is not suitable in women, and vardenafil effects during pregnancy or in breastfeeding women are unknown. Many anecdotal reports indicate that vardenafil is a first-choice medication for treating erectile dysfunction, works slightly faster than Viagra (sildenafil) and Cialis (tadalafil), it can work best if vardenafil be taken 30 to 60 minutes before sexual activity. Vardenafil can be taken with or without food. But drinking alcohol is not advised, as it reduces the chance of getting an erection. Alcohol can also increase the risk of adverse effects. However, Vardenafil works faster when taken on an empty stomach. The recommended starting vardenafil dosage is 10 mg, based on efficacy and tolerability the dose may be increased to 20 mg or decreased to 5 mg, and the maximum recommended dose is 20 mg. Vardenafil should not be taken more than once a day at any dose, dry your hands before vardenafil use, remove the dose from vardenafil package right away, place vardenafil tablet on your tongue and allow it to dissolve completely. Do not crush or split the tablet, vardenafil should not be taken with liquid, it need store at room temperature away from moisture and heat. Do not take vardenafil with similar effect medications together, such as avanafil (Stendra), sildenafil (Viagra), or tadalafil (Cialis), it might have a potential to interact with other medications or food that you’re taking. In meanwhile, avoid to use grapefruit products, drink alcohol and tobacco, will increase some of vardenafil side effects. You should speak with your doctor or pharmacist when you might take vardenafi tablet with these medicines, can help to avoid vardenafi interactions. (4) Avanafil Avanafil (Stendra) is an another PDE5 drug, used to treat male erectile dysfunction(ED). Avanafil works like other drugs in its class by increasing blood flow to the penis, without generic form, it's a safe and effective ED treatment. Unlike Tadalafil(Cialis) and Sildenafil (Viagra), it shows a greater selectivity for PDE5 over PDE6 than both sildenafil and vardenafil, but less selectivity than tadalafil. Avanafil may be used alone or with other medications, still not be known if avanafil is safe and effective in children. Many anecdotal reports indicate avanafil is a newest FDA approved ED prescription medication on the market, it work more faster than other medications in same class, just work in as little as 15 minutes. Avanafil can be taken with or without food, with great tolerated, it can lasts up to six hours. The rates of avanafil side effects are among the lowest of all PDE5 inhibitors. And, avanafil as a brand name medication, avanafi price will be more expensive than other sex-enhancing drug. It mainly appears in oral forms (tablets) for treating male ED issue, there are three strengths of avanafil tablets: 50 mg, 100 mg info@cmoapi.com

8. JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED www.cmoapi.com and 200 mg. For men taking 50mg avanafil dosage, need take 30 minutes before sexual intercourse; For men taking avanafil dose in 100mg and 200mg, that only take 15 minutes before sexual intercourse, and do not take avanafil more often than once a day. Avanafil need store at room temperature, away from excess heat and moisture (not in the bathroom), and out of reach of children. In addition, avanafil also has pharmacodynamic interactions, you need to talk with your doctor or pharmacist if plan to take other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products, that can help to avoid avanafi interactions and avanafi side effects. (5) Dapoxetine Hydrochloride Dapoxetine hydrochloride(hcl) is a short-acting selective serotonin reuptake inhibitor (SSRI), it was originally approved for the on-demand treatment of men with Premature ejaculation (PE). Dapoxetine works by inhibiting serotonin transporter and subsequently increasing serotonin's action at pre- and postsynaptic receptors, it's a white powder substance and water-insoluble, can be rapidly absorbed in the body, with well tolerated, it's an oral drug for Erectile Dysfunction and Ejaculatory Disorders. The starting dose of dapoxetine is one 30mg tablet, take dapoxetine tablet 1~3 hours before sexual activity, can be increased to dapoxetine 60 mg after 4 weeks for 12 weeks, the maximum recommended ddapoxetine dosage requency is once every 24 hours. The common dapoxetine side effects include dizziness, headache and nausea. When you're taking other medicines, please check with your doctor or a pharmacist and make sure can take with dapoxetine, can help to avoid dapoxetine interactions with other medicines. Sildenafil(Viagra), Tadalafil (Cialis), Vardenafil (Levitra) and Avanafil (Stendra) are the most commonly prescribed oral sex-enhancing Dysfunction(ED), they works by increasing blood flow to the penis, belong to a class of drugs known as PDE5 inhibitors.Sildenafil, Tadalafil, Vardenafil and Avanafil work in similar ways, just each drug has a slightly different chemical makeup, so each drug works will have minor differences affect, but they work well and cause few side effects. drugs for treat male Erectile Sildenafil vs Tadalafil (Viagra vs Cialis) Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat erectile dysfunction (ED), both only work when a man is sexually aroused, with similar efficacy and safety, can significantly improve male sexual confidence. However, more men prefer Tadalafil to sildenafil, as it lasts longer, works faster and with milder side-effects, tadalafil can't be affected by food to the same as sildenafil. And vice versa, info@cmoapi.com

9. JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED www.cmoapi.com some men prefer sildenafil after try tadalafil not suit to them. Sildenafil vs Vardenafil (Viagra vs Levitra) Vardenafil and sildenafil are also both PDE-5 inhibitors to indicated for treatment male erectile dysfunction(ED). In structurally, vardenafil is similar to sildenafil, it has more potent and more selective than sildenafil at inhibiting phosphodiesterase-5. vardenafil effect is similar to sildenafil, both can last for four to six hours. The only advantage of vardenafil to sildenafil, it does not inhibit phosphodiesterase-6 to alter colour perception, and sildenafil sometimes occurs a rare side effect. Both drug can be takend with meals, but Vardenafil tends to be less affected by food or alcohol. In addition, some reported inhibit vardenafil is more effective in diabetics than other erectile dysfunction medicines. For treat ED, Sildenafil vs Avanafil (Viagra vs Stendra) Sildenafil and Avanafil are similar in efficacy, belong to same drug of PDE5 inhibitors, both are well-tolerated. Avanafil is a second-generation phosphodiesterase type 5 inhibitor, only saled as brand-name, without generic form, i's a newest sex enchance drug on the market for treat erectile dysfunction (ED). Sildenafil and Avanafil are short-acting ED medications, but Avanafil works more quickly, with a slightly longer half-life, it usually works within 15 minutes after consumption. Avanafil become a fastest-acting erectile dysfunction treatment currently on the market. Just avanafil cost is much higher than other PDE5 inhibitors, but sildenafil seems to be much more popular, maybe sildenafil price is more lower and appear earlier on the market. Tadalafil vs Avanafil (Cialis vs Stendra) Tadalafil and avanafil work in a similar way, be used to treat male erectile dysfunction(ED), have many similar side effects and interactions. Avanafil was approved by US FDA in 2012 and became the fourth PDE5I on the market, with well-tolerated, the half-life of avanafil only has about a third of tadalafil. It has a rapid onset and shorter duration of action than tadalafil. info@cmoapi.com

10. JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED www.cmoapi.com Tadalafil vs Vardenafil (Cialis vs Levitra) Tadalafil (Cialis) and Vardenafil (Levitra) are FDA-approved to treat erectile dysfunction (ED), they come from the same class of chemicals, Tadalafil is a daily drug that used to treat enlarged prostate, Vardenafil is strictly used as a treatment drug for erectile dysfunction(ED). However, tadalafil can faster-acting than Vardenafil and lasts longer with effects, Tadalafil and Vardenafil are with similar side effects and interactions, both drugs can be used with or without food as needed before sexual activity, only Vardenafil's absorption may be affected by high-fat food intake, Tadalafil's absorption can't be affected by food. Vardenafil Tadalafil Phosphodiesterase-5 inhibitor Brand&Generic Oral tablet 5 to 20 mg as needed before sexual activity up to once daily as directed by a doctor at least 60 minutes before hand. stuffy or runny nose, headaches, flushing, upset indigestion, and back pain taken as needed, not recommend as long-term daily usage (PDE5) Phosphodiesterase-5 inhibitor Brand&Generic Oral tablet 5 to 20 mg as needed before sexual activity or 2.5 to 5 mg once daily as directed by a doctor 30 minutes before sex stuffy or runny nose, headaches, flushing, upset stomach, indigestion, and back pain taken as needed, daily use may be appropriate for some people. (PDE5) Drug class Status Form Standard dosage Lasts time Side effects stomach, Typical treatment Sildenafil vs Tadalafil vs Vardenafil vs Avanafil Sildenafil, Tadalafil, Vardenafil and Avanafil will not cure erectile dysfunction(ED), but they may provide relief from its symptoms. Everyone's body responds difference at sex-enhancing drugs, side effects vary from person to person, the only way to know which drug is best for you maybe through trial and error. Or you work directly with a doctor or pharmacist, to track side effects and decide which drug is best for your erectile dysfunction(ED) treatment option. info@cmoapi.com

11. JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED www.cmoapi.com Phosphodiesterase-5 inhibitors for Erectile Dysfunction(ED) Product Sildenafil Tadalafil Vardenafil Avanafil Brand Viagra Cialis Levitra Stendra Generic version Yes Yes Yes No Form oral tablet or liquid suspension oral tablet oral tablet oral tablet Typical dosage 25mg, 50mg, 100mg 2.5 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 20 mg 50 mg, 100 mg, 200 mg DurationTime 2~3hours up to 36 hours 4~5 hours 6~12 hours Onset(minutes) 30~60 15~30 30~60 15-30 Absorption effected by food Yes (high fat food) No Yes (high fat food) No Dosed as needed daily or weekender as needed as needed Storage At 25°C (77°F) At 25°C (77°F) At 25°C (77°F) Room temperature, between 68°F to 77°F (20°C to 25°C) Here some feedback from Redditors after trying sex-enhancing drugs to treat male ED: info@cmoapi.com

12. JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED www.cmoapi.com ---methhead_charizard "PDE5 inhibitors don’t make you hornier and don’t really induce spontaneous erections, they improve blood flow so when you are stimulated the erections are higher quality. So if you NEED porn to get stimulated they won’t change that fact. In the context of PE I think that PDE5 inhibitors would be reasonable for everyone to maximize blood flow. Any of the aforementioned options would work in that context, although again my preference is tadalafil" ---One_Indication ”I've been using tadalafil for about 3 years. and I'm now 63. I cut a 20mg tadalafil tablet into quarters(about 5mg) and take one every 3rd day. I have erections whenever I wish and I feel great. I must say that I sincerely believe that this use makes me way more horny than ever in my life” ---NortheastGuyinTX ”I take tadalafil 20 mg every morning with my vitamins. It stays in your system for up-to 36 hours, with a 1/2 life of 18 hours. Taking tadalafil daily regardless of any sexual plans works best for me. I have no side effects, and am raring to go at any moment. This helps with spontaneous moments. Once you find the right tadalafil dose, I suggest taking it routinely at the same time every day...” ---Jim_jonson ”Tadalafil helps me have a firmer, more reliable erection. I find that being harder reduces sensation and also anxiety over my erection, leading to lasting much longer esp. in doggystyle.” ---TheLoneDeranger76 ”I have had both and prefer tadalafil over sildenafil citrate. Especially if you plan to redose the MDMA, the tadalafil keeps working. Sildenafil citrate gives me acid reflux also. Tadalafil seems to work better too. Better erections and longer” ---Key_Dig_9315 ”Tadalafil is better than vardenafil, its effects last up to 36 hours also known as “weekend pill” but vardenafil and tadalafil effect last only 5 hours as well as less effective if you eat a high-fat meal but tadalafil works effectively without any issue.” ---FeelingWolf ”I'm 58 and have been using vardenafi 20 mg for several years. It works great for me and wife with little side effects.” info@cmoapi.com

13. JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED www.cmoapi.com ---JadmZimz4evr ”I have IPAH. I take tadalafil 40mg and Opsumit (macitentan) 10mg. That combo has worked out pretty well for me over the last 5yrs. A few hospitalizations here and there, but overall, much better than the 5yrs I spent undiagnosed. My specialist told me sildenafil isn't as strong as tadalafil, but same sex enchance drug family. The generic is called Alyq. Some insurances keep you on Sildenafil because it's cheaper. Maybe getting the generic will help minimize sildenafil cost.” ---CraftyLiving6 ”I'm 33yrs old. Me and wife are very active in our sex life. but this past few months Im having a hard time to have an erection, even though my mind and my body says yes, my penis is saying no. So I buy sildenafil and think it could help me and I was surprised it really worked for me. It was really hard. I feel it was gonna explode.” Here some feedback from Quora after trying sex-enhancing drugs to treat male ED: ---Andres Bruce ”Tadalafil shares a comparative efficacy and safety with Sildenafil Citrate and fundamentally improves patients' sexual accomplices incline toward tadalafil to sildenafil. Thus, tadalafil might be a superior choice for ED treatment” certainty. Moreover, patients and their ---Anthony Skilton ”A newer ED enhancement pill has hit the market in the recent years and it is Stendra (Avanafil). Here is a look at the Avanafil vs Sildenafil Citrate comparison. Both the drugs can help to treat your ED condition. Nonetheless, Avanafil has the upper hand, since has a longer duration of effectiveness and limited side effects. In addition,Sildenafil Citrate is more expensive and will not last longer. This can cause you a lot of money in the long run. All in all, Avanafil is the best of the two” ---Bob Smith ”Tadalafil(Cialis) Daily, known as a weekend pill, is one of the most effective solutions for patients with erectile dysfunction. The effective and long action of the drug makes it possible to maintain a stable and long erection, treat premature ejaculation and other dysfunctions. Tadalafil daily is one of the best-selling sex enhance drug in the world today” --Dennis Rodrigue ”Erectile dysfunction and premature ejaculation are the two sexual disorders found in men. Dapoxetine 60mg plays an important role in maintaining the ED and PE during info@cmoapi.com

14. JINAN CMOAPI BIOTECHNOLOGY CO., LIMITED www.cmoapi.com intimate sessions” ---Amit Panigrahi ”While drugs like Sildenafil (viagra), Tadalafil (Cialis) help i case of erectile dysfunction (ED), they do not really help in extend the period of intercourse. For such cases (means delaying ejaculation, i.e. increasing intercourse time) another drug Dapoxetin is being used. You can find drug products containing dapoxetin to extend the duration of intercourse. Some combinations are also Tadalafil+dapoxetin...” available like sildenafil+dapoxetin, ---Dr.Stam Poupalos ”Erectile dysfunction is a symptom rather than a condition as it can have several different causes. Psychological ED may be considered curable in some instances whereas physical ED, due say to nerve damage or circulation problems, is treatable if not curable. Either way help is available that can overcome the condition.” ----Bob Nicholson ”To be honest, it doesn't matter where you are. The most effective treatment for ED is a PDE-5 inhibitor (Sildenafil Citrate, Tadalafil, Vardenafil, and generic equivalents)....” ---Dana Shultze ”Sildenafil is used by those having Erectile Dysfunction issues in men. Sildenafil as well as Viagra. Sildenafil is this mild powered pill is also indicated for treating pulmonary arterial hypertension (PAH). Sildenafil works by relaxing muscles in the penile and enhancing blood flow in it. This complete action mechanism of drug helps men to achieve and maintain an erection for a longer time” ---José Saravia ”It seems like sildenafil works for bodybuilders, the reason is that the molecule nitric oxide is a key component of sildenafil and many bodybuilding supplements are built around this same molecule and are marketed for use as pre-workout vasodilators. Also, many bodybuilders, takes Sildenafil along with anabolic steroids prior to a workout.” Purchasing prescriptions online is easier and faster than ever. If you need to purchase sex-enhancing drugs for treating male ED issue through a variety of online platforms. you'd better to buy it from a vendor with a track record for selling safe and effective sex-enhancing drugs. Based on our experience and positive feedback from buyers, cmoapi.com is a reputable sex drugs supplier that delivery top quality product at competitive prices. info@cmoapi.com