Everything You Need to Know About Nicotinamide Riboside Chloride

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www.wisepowder.com wise12@wisepowder.com Millions of people out there spend so much money on anti-aging products like Nicotinamide Riboside chloride. Even though aging is a natural process, people just don’t want to look old. The good news is that, there are several products out there that may actually help with this and Nicotinamide Riboside Chloride is one of them. In this post, we will be focusing on the product. We will give you information about it, how it works, its benefits, where to buy it, and additional tips to help you better make the most of it. What is Nicotinamide Riboside Chloride? So, let’s start with the most basic question. Forget about the big and complicated name. Nicotinamide Riboside Chloride CAS 23111-00-4 is actually an alternative form of Vitamin B3, often referred to as niacin. Nicotinamide Riboside Chloride may also be called niagen or shortened as NR. Once ingested in the body, it will be converted into Nicotinamide adenine dinucleotide or NAD+. NAD+ is one of the most important enzymes in human physiology. It is responsible for fueling a number of key biological processes including the conversion of food into energy and fortifying the defense systems found within each cell. The enzyme may also be crucial in repairing damaged DNA and can have an additional positive effect in promoting healthy aging. The body can produce its own NAD+ enzyme easily without supplementation. The sad part is that, as you continue to age, the amount of NAD+ produced by the body declines. In essence, older people will have lower levels of this important enzyme compared to younger ones. This is where supplementation becomes very important. Using Nicotinamide Riboside Chloride supplements to enhance NAD+ levels, especially among older people, may offer a number of incredible benefits. 2 / 18

www.wisepowder.com wise12@wisepowder.com First of all, declining levels of NAD+ have been likened to age-related chronic illness including diabetes, Alzheimer’s, heart failure, and vision loss. There is also some evidence showing that rising NAD+ may reverse signs of aging. Ultimately, the use of a Nicotinamide Riboside chloride supplement does not only help you look younger and more confident. It also helps to lower the possible risk of chronic illnesses as you age. How Does Nicotinamide Riboside Chloride Work? The primary purpose of Nicotinamide Riboside chloride vs niacin supplementation is to enhance the levels of NAD+ in the body. NR is a vitamin that is found in very small traces in our normal diet. Once the substance is ingested, it will be converted through normal metabolic processes to NAD+. What makes NR a good option for people looking to increase NAD+ levels is the fact that it’s highly bioavailable. As we have noted above, NR is a form of Vitamin B3. There are dozens of food sources out there that can deliver Vitamin B3. However, the rate in which Nicotinamide Riboside Chloride is absorbed in the body is relatively faster compared to other B3 forms in the diet. This makes it one of the most reliable and effective modes of supplementation for NAD+ in the human body. 3 / 18

www.wisepowder.com wise12@wisepowder.com Nicotinamide Riboside Chloride Benefits/Effects The benefits of Nicotinamide Riboside Chloride can only be viewed in relation to the role NAD+ plays in the body. 4 / 18

www.wisepowder.com wise12@wisepowder.com This is because supplementation of NR will raise NAD+ levels and in turn this important coenzyme will deliver the following Nicotinamide Riboside Chloride benefits: 1. Healthy Aging The increased production of NAD+ in the body may trigger the production of certain enzymes that may help to enhance healthy and graceful aging. In animal studies, the coenzyme managed to trigger the production of an enzyme called sirtuins. Sirtuins appeared to improve the lifespan and the general health of animal test subjects during clinical studies. Other studies also show that Sirtuins can help to boost stress resistance in humans and repair damaged DNA as well. 2. Improve Cell Defense Mechanism in the Brain NAD+ can also protect brain cells from irregular degeneration, especially with aging. Some studies show that NAD+ may control the production of a protein called PGC-1-alpha. The protein is significantly vital in protecting cells against oxidative stress. It may also improve and repair mitochondrial functions in brain cells, leading to better cognitive health. There are also dozens of research studies linking oxidative stress and damaged mitochondrial functions in brain cells with age-related brain disorders such as Alzheimer’s, Parkinson’s and others. The action of NAD+ in reducing these processes could significantly reduce the risk of Alzheimer’s and other degenerative brain diseases. 5 / 18

www.wisepowder.com wise12@wisepowder.com The effectiveness of NAD+ in this is actually very high. In some animal studies where mice with Alzheimer’s were treated with Nicotinamide Riboside Chloride, the levels of PGC-1-alpha in the brain increased by between 50 and 70%. By the end of the studies, the mice treated with NR showed significant improvement in memory-based tasks. 3. Nicotinamide Riboside Chloride May Help with Heart Problems The risk of heart failure increases significantly with aging. Heart failure is also a very common issue in fact it is the number one cause of death globally. Overall heart health is dependent on many factors though including proper diet and exercise. But there are certain things that may lower the risk. Increased production of NAD+ is one of these things. Test studies done on animals found that increased production of NAD+ helped to reverse potentially dangerous changes in blood arteries caused by aging. In some human-based studies, high levels of NAD+ led to the reduction of stiffness in the aorta. NAD+ was also reported to lower the potential risk of systolic blood pressure. This simply means that there is real potential of using Nicotinamide Riboside Chloride as a possible supplement in reducing the risk of heart disease. However, there is still need for additional human research to better understand the potential. In addition to these benefits, Nicotinamide Riboside chloride may also help with Weight loss. This is because high levels of NAD+ may enhance metabolism rates in the body. High NAD+ levels also prevent DNA damage and oxidative stress, two factors that have been linked with cancer. The coenzyme may also have positive effects on promoting healthy muscle aging as well. 6 / 18

www.wisepowder.com wise12@wisepowder.com How to Use Nicotinamide Riboside Chloride Nicotinamide Riboside Chloride is commonly sold as niagen. The product is sold in capsules online and is ingested using the mouth. Although a majority of niagen products contain just the Nicotinamide Riboside Chloride, some may also feature additional ingredients including polyphenol or Pterostilbene. The manufacturers often recommend a Nicotinamide Riboside chloride dosage of between 250 mgs and 300 mgs per day. This is roughly the same as two capsules of the product each day. Nicotinamide Riboside Chloride vs. Nicotinamide Riboside (NR) The only difference between these two substances is the formulation. However, they have an almost similar working mechanism. The job of both Nicotinamide Riboside Chloride and Nicotinamide Riboside is to enhance the production of NAD+ in the body. The two are also alternative forms of Vitamin B3. Nicotinamide Riboside Chloride vs. Nicotinamide Mononucleotide (NMN）） The debate of Nicotinamide Riboside chloride vs NMN is not that huge. Nicotinamide Mononucleotide (NMN), just like Nicotinamide Riboside Chloride, is a derivative of niacin. The two substances are also similar in the way they work. They are ingested and converted into NAD+ once they enter the human body. Additionally, both of these substances are also synthesized from a combination of ribose and Nicotinamide. 7 / 18

www.wisepowder.com wise12@wisepowder.com What Foods Contain Nicotinamide Riboside? Most of our diet contains very little amounts of Nicotinamide Riboside. However, for most people, an average diet, with loads of Vitamin B3, should be enough to provide the required intake of Nicotinamide Riboside. Here are several foods that may help with this: 8 / 18

www.wisepowder.com wise12@wisepowder.com  Dairy Milk– Cow milk comes loaded with a lot of Nicotinamide Riboside.  Fish– You may also get NR from Fish. Tuna, sardines, and salmon all have very good levels of Nicotinamide Riboside.  Beer– Surprisingly, beer may also help you supplement Nicotinamide Riboside. This is because beer has yeast as one of its main ingredients and the yeast is known to be very high in NR.  Chicken– Eating chicken may also boost NR levels in your body as well. A serving of chicken, roasted, fried, or stewed, contains up to 9.1 milligrams of Nicotinamide Riboside.  Green Vegetables– Green veggies are also advisable. They are loaded with loads of vitamins, including the all-important B3 that will be crucial in the synthesis of NAD+ in your body.  Yeast – Finally, if you are not able to get enough Nicotinamide Riboside from beer, perhaps you may want to ingest the yeast separately. Yeast is very high in Nicotinamide Riboside and should be incorporated into your diet. Is Nicotinamide Riboside Chloride Safe? Nicotinamide Riboside chloride bulk is a very safe supplement to use but just like any product, it has several potential side effects that you should be aware of. In some human studies, test subjects were given between 1000 milligrams and 2000 milligrams of Nicotinamide Riboside Chloride and did not witness any harmful effects whatsoever. So far, manufacturers of Nicotinamide Riboside Chloride recommend between 200 mgs and 300 mgs of the product a day. 9 / 18

www.wisepowder.com wise12@wisepowder.com Despite this safety record, Nicotinamide Riboside Chloride may have a few side effects to keep in mind. First, some people have reported feeling nauseated after using the product. In other cases, patients felt fatigued and headaches as a result of Nicotinamide Riboside Chloride. It is also not uncommon to experience digestive issues including stomach discomfort and diarrhea. However, the severity of Nicotinamide Riboside chloride side effects is very different from one individual to another. Some people do not even experience these effects at all. If you are on any other medications, talk to your doctor first before using Nicotinamide Riboside Chloride. Nicotinamide Riboside Chloride Buy Online If you feel Nicotinamide Riboside Chloride could offer some amazing benefits for your overall health, then you will be happy to know that the product is available in many stores. You can also buy online or offline. Nicotinamide Riboside Chloride is largely sold as niacin. It comes in capsules too. However, you may want to take your time as you search for a buyer. Even though there are many vendors who are going to offer you a quality product, there are still a huge number of fake sites that just want to scam you. Here are some tips that will help you find genuine sellers:  Check out reviews. It’s always a great idea to know what other customers are saying about a vendor before you buy. 10 / 18

www.wisepowder.com wise12@wisepowder.com  Check out the prices as well. Although Nicotinamide Riboside Chloride buy is not too expensive, it’s also not that cheap. Vendors selling the product at unreasonably low prices should be avoided.  It may also be a good idea to ask for a direct recommendation. Instead of just jumping online and trying to find Nicotinamide Riboside Chloride supplements, talk to someone who has bought these products before and see if they can get you in touch with a genuine seller. Doctors too may have some ideas on where to start and more info on Nicotinamide Riboside chloride vs NADH. Nicotinamide Riboside Chloride is a very popular anti-aging supplement. It can help reverse aging signs and keep you in proper health. The guide above should help you find a genuine product out there. 11 / 18

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www.wisepowder.com wise12@wisepowder.com Article by: Dr. Liang Co-founder, the company’s core administration leadership; PhD received from Fudan University in organic chemistry. More than nine years of experience in organic synthesis field of medicinal chemistry. Rich experience in combinatorial chemistry, medicinal chemistry and custom synthesis and project management. 18 / 18

Everything You Need to Know About Nicotinamide Riboside Chloride