Acute Myeloid Leukemia Market

1. Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous malignancy characterized through clonal proliferation and impaired differentiation of myeloid precursors with various outcomes. Quickest-growing cancer happens when the bone marrow begins to form cells that have not yet absolutely matured as blasts. These cells crowd the bone marrow, stopping it from making normal blood cells and leukemia starts to crowd out the normal white blood cells, crimson blood cells, and platelets that the frame desires. In Acute myeloid leukemia, the bone marrow additionally makes strange crimson cells and platelets. As consequence, the blood cells do not develop, and it gets hard to ward off infections. Acute Myeloid Leukemia Signs and Symptoms The symptoms of acute myeloid leukemia generally expand over a week and become an increasing number severely. Signs can include anemia, light skin, constant tiredness, joint infections, frequent bleeding, bone pain, and others. Acute Myeloid Leukemia Epidemiology Acute Myeloid Leukemia accounts for <3% of all cancer, and 25% of all leukemia in adults. Worldwide, the incidence of Acute Myeloid Leukemia is reported to be highest in the US, Australia, and Western Europe. The incidence has been near stable over the last years. Incidence continuously shows 2 peaks in occurrence in early childhood and later adulthood. From 2000 to 2003, the US incidence rate in people aged <65 years was only 1.8 per 100,000 persons, whereas the incidence rate in people aged 65 years was 17 per 100,000 persons. The Acute Myeloid Leukemia incidence rate of 3.7 per 100,000 inhabitants in Europe with a 5-year survival rate of 19%. A cross-national study using US and England data found that the overall risk of mortality for Acute Myeloid Leukemia was 23% lower in England compared to that in the US. However, survival difference was similar in subgroups of sex and age at diagnosis. According to a study, the yearly average incidence rate of leukemia was 3.68/105 during 2003-2007 in Nanjing. There were no significant differences in gender, the incidence rate was the highest in the group aged 80~ years. Acute Myeloid Leukemia Treatment Options

2. Acute Myeloid Leukemia is common leukemia affecting adults and poses a major medical challenge with increased mortality and morbidity. Once diagnosed, the treatment needs to start as quickly as possible. The treatment depends on age, risk factors, and the sub-types of Acute Myeloid Leukemia. The aim of treatment for Acute Myeloid Leukemia is to cure it and achieve remission of leukemia cells. Traditionally, the standardized treatment was chemotherapy which can be divided into intensive chemotherapy and non-intensive. The intensive chemotherapies are two phases of remission induction followed by post-remission consolidation-based therapy. The induction therapy includes drugs such as Cytarabine, Daunorubicin, Idarubicin, and Fludarabine either alone or in combinatorial doses. Consolidation therapy is presented in such cases where induction therapy failed to work, with drugs such as Etoposide, Amsacrine, and Mitoxantrone. Acute Myeloid Leukemia Market FLT3 Inhibitors such as Midostaurin and Gilteritinib; IDH Inhibitors such as Enasidenib and Ivosidenib; and Hedgehog pathway inhibitor, such as Glasdegib; BCL-2 inhibitor such as Venetoclax have recently entered the Acute Myeloid Leukemia market as promising targeted therapies with specific genetic mutations. As the first directed agent that works very well in the elderly population with Acute Myeloid Leukemia, Venetoclax and Glasdegib has opened possibilities in the world of targeted therapy. Gilteritinib, Enasidenib, and Ivosidenib were approved explicitly for relapsed and refractory Acute Myeloid Leukemia, with specific genetic mutations. This spell of new drug approvals has altered the Acute Myeloid Leukemia Market and provided new opportunities. Various companies such as Actinium Pharmaceuticals, AVEO Oncology, Biodesix, Daiichi Sankyo, BioSight, Helsinn Healthcare, Rafael Pharmaceuticals, Otsuka Pharmaceutical, Cyclacel Pharmaceuticals, and others are developing effective therapies, which contribute to the market size of Acute Myeloid Leukemia. There are many competitors in the development phase for the treatment of AML such as Iomab-B CD45 and Actimab-A CD33 (Actinium Pharmaceuticals), Ficlatuzumab (AVEO Oncology and Biodesix), Devimistat (Rafael Pharmaceuticals), BST236 (BioSight), Bemcentinib (BerGenBio), Pracinostat (Helsinn Healthcare) and others.