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Lecture 25 Respiration #2

Lecture 25 Respiration #2. Diseases detected by PV curves. Air flow transducer - Pneumotachometer. Nitrogen washout. Air flow transducer. Full body plethysmograph. Measurement of airway resistance. Dubois shutter method

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Lecture 25 Respiration #2

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  1. Lecture 25Respiration #2

  2. Diseases detected by PV curves

  3. Air flow transducer - Pneumotachometer

  4. Nitrogen washout

  5. Air flow transducer

  6. Full body plethysmograph

  7. Measurement of airway resistance • Dubois shutter method • Measurement of pressure in full body plethysmograph using calibration Pump • PV=NRT = gas law

  8. Compliance –static model

  9. Dynamic compliance C = Volume/Pressure Volume = integrate flow Press = difference at flow=0

  10. Pressure volume curves

  11. Pulse Compliance

  12. Detector for respiratory cycle position

  13. Instantaneous compliance

  14. Compliance –instantaneous

  15. Harry Puffer setup

  16. Retrograde catheter(set R=0)

  17. Pulse stimulus

  18. Pressure units • Atmospheric pressure ~14.7 pounds/sq inch • Daily barometric pressure - 30 cm Hg or 762 mmHg • Or 10.3 meters water or 33 ft

  19. Pressure calculations • Today’s barometric pressure = 30.03 cm Hg • Or 760 mmHg • % Oxygen = 20.94% • Partial pressure of oxygen ~160 mmHg • Pressure of oxygen in hemoglobin = 100 • Venous oxygen pressure = 40

  20. Hemoglobin dissociation curve Effect pf Ph (Push to Right) Effect of sickle cell (push to left) Carbon monoxide Temperature (push to right) Organic Phosphates (push to right)

  21. Gas pressures at body locations

  22. Other pressure effects • High altitude • Mount Kilimanjaro • Mount Everest • Blood Oxygen saturation – ear clip • Measurement of PO2 • Carbon dioxide in brain – hyper ventilation • Sleep patterns • Artificial lungs

  23. Ventilators • Design • Purpose • How it feels • High frequency type • Neonatal nursery • Danger of pure oxygen

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