What is Haploidentical Transplantation

1. DR PAWAN SINGH Dr Pawan Kumar Singh has the experience of performing more than 500 bone marrow transplants (including Autologous /Allogenic /Haplo /MDU )for both malignant and non-malignant disorders. 2025

2. Introduction to Haploidentical Transplantation Haploidentical transplantation is a groundbreaking procedure that allows life-saving treatment for patients with hematological diseases such as leukemia, lymphoma, and other blood disorders. It involves the transplantation of stem cells from a half-matched (haploidentical) family member, often a parent, child, or sibling. This option provides hope for patients who cannot find a fully matched donor.

3. 01 02 03 What is Haploidentical Transplantation? Definition: A form of stem cell transplantation where the donor is genetically related to the patient but shares only half of the HLA (human leukocyte antigen) markers. Importance: In cases where no fully matched donors are available, haploidentical transplantation opens up a wider pool of potential donors.

4. How Haploidentical Transplantation Works Why Haploidentical Transplantation Matters • Donor Selection: A family member (typically a parent, sibling, or child) is chosen as the donor, and the degree of genetic compatibility (half-match) is assessed. • Conditioning Regimen: The patient undergoes a treatment process to destroy abnormal cells and prepare the body for the transplant. • Increasing Demand for Bone Marrow Transplantation: Many patients, especially those suffering from life-threatening blood cancers, struggle to find a perfect match for bone marrow transplants. • Lack of Donor Matches: Approximately 70% of patients are unable to find a fully matched donor from unrelated sources. • Family Members as Donors: Haploidentical transplantation offers an opportunity to use family members as donors, increasing the chances of a successful transplant. • Stem Cell Infusion: The donor’s stem cells are infused into the patient, where they can develop into healthy blood cells. • Recovery and Monitoring: After the transplant, the patient’s immune system is carefully monitored to prevent complications such as infection or graft-versus-host disease (GVHD).

5. Benefits of Haploidentical Transplantation • Expanded Donor Pool: Unlike fully matched transplants, which require an exact genetic match, haploidentical transplants can use family members, even if they are only a 50% match. • Faster Treatment: This method reduces waiting times for a suitable donor, which is critical for patients in urgent need. • Life-Saving: For many patients, particularly those with high-risk blood cancers, haploidentical transplantation can be the difference between life and death.

6. 2025 Conclusion Haploidentical transplantation is a life-saving procedure that has revolutionized the treatment options for patients with blood cancers and other hematologic diseases. Through advances in medical science and transplantation techniques, we can offer hope to those who otherwise might not have found a matching donor. Continued research and innovations in post-transplant care will further improve success rates and quality of life for patients worldwide.

7. Dr. Pawan Kumar Singh • BLK-MAX SUPER SPECIALITY HOSPITAL, RAJENDRA PLACE NEW DELHI MD-Medicine, DM (Haemato- Oncology AIIMS) THANK YOU 09:00 AM - 05:00 PM BONE MARROW TRANSPLANT (BMT) SPECIALIST • Book Appointment • +91-9354700860/ 8750637212