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Epidemiologic International Day For the Evaluation of Patients at Risk for Venous Thromboembolism in the Acute Hospital

Epidemiologic International Day For the Evaluation of Patients at Risk for Venous Thromboembolism in the Acute Hospital Care Setting. Sponsored by an unrestricted educational grant from sanofi-aventis to the Center for Outcomes Research, University of Massachusetts Medical School.

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Epidemiologic International Day For the Evaluation of Patients at Risk for Venous Thromboembolism in the Acute Hospital

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  1. Epidemiologic International Day For the Evaluation of Patients at Risk for Venous Thromboembolism in the Acute Hospital Care Setting Sponsored by an unrestricted educational grant from sanofi-aventis to the Center for Outcomes Research, University of Massachusetts Medical School

  2. Unique Strengths • Cross-sectional cohort study • Multi-national perspective • Representative populations • Hospitals • Patients • National and worldwide estimates of VTE risk factors and prophylaxis use

  3. 35 ENDORSE Countries

  4. Algeria Australia Bangladesh Brazil Bulgaria Columbia Czech Republic Egypt France Germany Greece Gulf States Russia Saudi Arabia Slovakia Spain Switzerland Thailand Tunisia Turkey UK USA Venezuela 35 Participating Countries • Hungary • India • Ireland • Israel • Italy • Mexico • Morocco • Pakistan • Poland • Portugal • Romania

  5. Objectives • To identify patients at risk for venous thromboembolism (VTE) among medical and surgical patients hospitalized in representative hospitals throughout the world • To determine the proportion of at-risk hospital patients who receive effective types of VTE prophylaxis

  6. Study Design • Cross sectional, observational survey • Enroll patients at “a single point in time” • Actual enrollment may take one month • Multinational perspective • Representative hospitals in each country • Consecutive patients within pre-specified wards

  7. Hospital Inclusion Criteria • Acute care hospitals • Randomly selected from country-wide lists • More than 50 beds • General medical & surgical wards • At least one general surgical ward • Schedule elective major surgical cases • Agree to participate in ENDORSE

  8. ENDORSE Steering Committee Co-Chairs: Ander Cohen & Victor Tapson Committee Members Jean-Francois Bergmann France Ander Cohen United Kingdom Samuel Goldhaber United States Ajay Kakkar United Kingdom Victor Tapson United States Director, Study Coordinating Center Fred Anderson United States

  9. Study Timeline

  10. Motivation for Hospitals to Participate • Provide investigator at each hospital a confidential summary report showing a local profile of DVT risk and prophylaxis use, benchmarked against the country • Reimburse for effort of local data abstractor Or • Provide a data abstractor contracted by a CRO

  11. ENDORSE will Overcome Important Limitations of IMPROVE • Multinational perspective • Representative • Hospitals • Both medical and surgical patients • Can be used to make national estimates • Magnitude of VTE risk in-hospitals • Gap between trial evidence and real-world practices in prophylaxis use

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