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“Recent Research Stories” (Silent Version) “Recent Research Stories” (Silent Version) For sound, please feel free to come see me. Cheers, Geoff
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“Recent Research Stories” (Silent Version) For sound, please feel free to come see me. Cheers, Geoff
Previous Graduates from the Rosenfeld Laboratory Susan Amara Rouping Chen Bryan Crenshaw Daniel Drolet Glen Evans Xi He Ola Hermanson Jeff Holloway Holly Ingraham Kristen Jepsen Michael Kapiloff Chrissa Kioussi Peng Li Steve Lipkin Sergio Lira Professor, Vollum Institute, Investigator, HHMI Staff Scientist, Celera Genomics Assoc. Professor, University of Pennsylvania Assoc. Research Director, NeXagen Inc. Professor, Univ of Texas, Southwestern, School of Medicine Asst. Professor, Harvard Medical School Assist. Professor, Karolinska Institute, Stockholm, Sweden Staff Scientist, Unigen Pharmaceuticals Inc. Professor, UC San Francisco Assoc. Research Scientist, UC San Diego Assist. Professor, Univ of Oregon, School of Medicine Assist. Professor, Oregon State University Professor, The Singapore Institute of Biology Assist. Professor, UC Irvine, School of Medicine Adjunct Professor, Mt. Sinai School of Medicine 3
Previous Graduates from the Rosenfeld Laboratory(continued) Assoc. Research Scientist, UC San Diego Assoc. Professor, Univ of Oregon, School of Medicine Assist. Professor, Harvard Medical School Assist. Professor, University of Massachusetts Assoc. Project Scientist, UC San Francisco Assist. Project Scientist, UC San Diego Assist. Professor, Stanford University Postdoctoral Fellow, University of Washington Project Scientist, Illumina Professor, UC Irvine, School of Medicine Assist. Professor, University of Massachusetts Robert McEvilly Geoffrey Murdoch Anders Näär Franco Rodrigo Marcus Schonneman Kathleen Scully Mark Sornson Daniel Szeto Jo Yeakley Marion Waterman Lan Xu 4
Biochemical Identification of the Nuclear Receptor Corepressor (N-CoR) 6
Identification of the Minimal Corepressor/NR Interaction Motif 8
Transient Signaling Gradients and InducedTranscription Factors in Pituitary Development 15
DNA Binding-independent Functions of Pit-1 Restrict Gonadotrope Gene Expression Out of Thyrotropes 19
Three Pit-1+ Cell Types Express DistinctHormone-encoding Gene Targets 20
Co-crystal Structure of Pit-1 POU Domainson GH and Prl DNA Response Elements 21
Combinatorial Recruitment of a Corepressor Complex inLong-term Active Repression of the GH Gene 22
toy ey/Pax6 so/Six optx/six6 eya/Eya dac/Dach SD HD Six Drosophila sine oculis Mutations Zipursky et al. Neuron Vol. 12, 977-996 1994 23
Six6-/- Retinal ProgenitorCells Has Reduced Proliferation Potential 24
Six6/Dach2 are Required forPrecise Regulation of RPC Proliferation 25
Model of Eya Phosphatase Actions inSix1/Dach/Eya Regulation of Organogenesis 29
-/- +/+ pituitary -/- +/+ +/+ -/- tooth +/+ -/- Phenotype of Pitx2 Gene-deleted Mice Visceral and Axial Turning Abnormalities lung Right Pulmonary Isomerism Organ Determination and Proliferation 31
IL-1-dependent KAI1 Gene Induction Based on a Corepressor/Coactivator Exchange 34
Presenilin-dependent Generation ofTranscriptional Coactivators 38
Model of CoREST-dependent Silencingof a Chromosomal Interval 41