Process Development Division Area 12B -Pilot Plants

1. Process Development Division Area 12B -Pilot Plants AIChE 2007 Fall Meeting Salt Lake City, UT Tues. 11/6 at 11-noon Room 155D

2. AGENDA • Introductions • Mission Statement Review • Area Leadership • Programming Review (2006 - 2010) • Future Programming Topics • Current Action Items • New Business • Area 12b Leadership Roles

3. Mission Statement The Pilot Plant Area is a forum for active interchange of ideas and for the continual improvement of Pilot Plant contributions to quality research and effective scale-up. AIChE programming, benchmarking, operation reviews, and extensive networking form the backbone of the Area activities.

4. Area 12B Leadership • Outgoing Chair: Joe Powell, Shell • New Chair: Dan Pintar, UOP • New Chair Elect: Adam Whalley, Zeton • New Activities Chair: David Attride (Eastman) • Past Chair: David Edwards, Zeton

5. Programming…. Spring 2006 (Orlando, FL) • Pilot Plant Success Stories • Chair : David Edwards • Vice-Chair : Raymond Rooks • 4-Session Mini-Topical for 12A & SEF: Sustainability in Practice • Joe Powell, chair • Book to be drafted (in progress; contract approved, 2007)

6. Programming…. Fall 2006 (San Francisco, CA) Pilot Plants Mini-Topical: Pilot Plant Design and Optimization Chairs: Dan Pintar, Joe Powell • Unit Operations : Scale Up and Scale-down in Pilot Plants • Joe Powell, Osman Aboul-Nasr • Pilot Plants in the Food and Consumer Products Industries • Marc Privitera, David Reeder • Strategies in Biopharmaceutical Scale-up & Pilot Plants • Nihal Tugcu (15b), Adam Whalley (12b) • Poster Session : Pictures of Pilot Plants and University Unit Operation Labs • John Corn

7. Programming…. Spring 2007 (Houston, TX) • Tools and Best Practices in Pilot Plants-I • Chair : Joe Powell (Shell) • Co-Chair : David Attride (Eastman) • Attendance 32; Include representation of 12B pilot plants benchmark study from 2004. • Tools and Best Practices in Pilot Plants-II • Chair : Joe Powell (Shell) • Co-Chair : David Attride (Eastman) • Attendance 27 • Sustainable Optimization and Troubleshooting of Chemical Processes Attendance 19 - 27 • Chair : Sue Degaleesan (Shell) • Co-Chair : Benson Pair (KBR) • Co-sponsor SEF & 12d

8. Programming…. Fall 2007 (Salt Lake City, UT) • Solids Handling in Pilot Plants • Bruce Hook (Dow) • Vice Chair: Joe Powell (Shell) • Careers in Pilot Plants and Process Development • Chair : Dan Pintar (UOP) • Vice-Chair : Salvador Aldrett (Shell) • Strategies in Pharmaceutical Scale-up and Pilot Plants • Chair: Brent Nielsen (Bristol-Myers Squibb) • Co-Chair: Elizabeth Spiteri (Bristol-Myers Squibb)

9. Programming…. Spring 2008 (New Orleans, LA) • Current Challenges in Pilot Plant Operation • Chairs: Cawas Cooper and Tony Cartolano (Air Products) • Co-Chair: Adam Whalley (Zeton) • Process Chemistry and Catalysis in Pilot Plants and Process Development (ACS CoSponsor) • Chair: Joe Powell (Shell) • Co-Chair: David Attride (Eastman) • Gasification & pyrolysis pilot plants • Chair: David Edwards (Zeton) • Co-Chair: Dan Pintar (UOP)

10. Programming…. Fall 2008 (Philadelphia, PA) Session topics or topical conference to be chosen to coincide with AIChE’s centenary celebrations • Pilot Plant Centenary Celebration Topical: David Edwards (Zeton) / Jean Tom (Bristol-Myers Squibb) = topical chairs • Instrumentation and control • Chair: David Edwards (Zeton); Co-chair: Mike Doll (Shell) • Pharmaceutical: chiral catalysis and separations** • Chair: Jean Tom (BMS); Co-chair: John Peragine (BMS) • Reaction engineering / reactor design • Chair (Sue Degaleesan- Shell); Co-Chair (Cawas Cooper, Air Products) • Pilot Plants through History • Chair: Joe Powell (Shell), Co-Chair: Dan Pintar (UOP) • Challenges in Pharmaceutical Process Development and Scale-up (15b cosponsor) • Chair: Sanjeev Katti (Genzyme), Cochair: Bob Anthes (BMS) • Modeling Unit Operations and Data Mining: Application to Pilot Plants • Chair: Praveen Sharma (BMS); Cochair: Merril Galloway ** possibly redundant with “Challenges” session. • Consider Rich Palluzi short course? ½-day course? Part of topical. Consider presentation sponsored via YPAB (Young Professional Advisory Board).

11. Programming…. Spring 2009 (Tampa, FL) • Shortcut Methodology in Pilot Plants • Chair : Joe Powell, Shell • Co-Chair : Dan Pintar, UOP • Heavy oil upgrading, hydrotreating & refining pilot plants • Adam Whalley (Zeton) • Dan Pintar (UOP) • High Throughput Crystallization • Chair Jean Tom (BMS)

12. Programming…. Fall 2009 (Nashville, TN) • Biotech and Biopharma Pilot Plants • Misti Ushio (Merck 12b), Vice Chair (15c) • Pilot plant: Data mining and modeling • Chair: Praveen Sharma, (BMS) • Pilot Plant Metrics and Productivity • Chair: Dan Pintar (UOP), Vice Chair (TBA)

13. Potential Session Topics... • Analytical techniques/devices for pilot plants • Pharmaceutical pilot plants - regulations and environmental challenges • Process safety management in pilot plants • Bio-informatics/Bio-technology • Generic drugs and related topics • Bio-processing • Bio-tech Pilot Plants • Polymer Processing in Pilot Plants • Syngas Pilot Plants • Contract Pilot Plants (contracting either as a supplier of pilot plant services or a client) • Constructability issues for Pilot Plants • Careers in Pilot Plants and process development (done) • Microbiological and Cleanliness Challenges in Pilot Plants • Internal & Contract Vs. Toll Pilot Plants • Novel reaction techniques in Pilot Plants (e.g. microwave) • Pilot Plant metrics and productivity • Pilot plant topical combined with vendor exhibit • Design competition / alternative energy model car

14. Potential Session Topics • Miniaturization of Pilot Plants • Cost-Driven Pilot Plants (Funding) • Process Control and Data Acquisition in Pilot Plants • Marketing of Pilot Plants (internal see next topic or External for purposes of contracting services) • Time-to-Market • Successful Pilot Plant Design • Pilot Plant Productivity (Metrics used to define equipment/personnel/reliability) • Pilot Plants as Part of the Corporate Structure/Organization • Optimum Sizing of Pilot Plants • Internal or Contract Pilot Plants ? • Pilot Plant Tools and Techniques • Pilot Plant Equipment Selection • Use of Computer Simulation to Support Pilot Plant Design and Operation

15. Current Action Items • Oversee Chemical Process Development Web Forum and Vendor Area (DE)…hosted on www.eng-tips.com; opportunity. • Opportunities for courses include ASME and Univ. of Wisconsin continuing education. No interest in developing AIChE sponsored course at this time. • Publish book on Sustainability in Practice • Publish Pilot Plant Benchmarking results in CEP (JBP / BD) ongoing

16. New Business • Solicit session chairs and co-chairs for 2008-10 (ongoing) • Adam Whalley (Zeton) elected as 12b activities chair (elected to vice-chair in Fall 2007). • Possible Process Development or Pilot Plant Best Practices Edited Book (Wiley): • Publish pilot plant benchmarking first

17. Area 12b Leadership Roles Area 12b Past Chair The Area 12b Past Chair oversees the handover of action items and responsibilities to the incoming Area 12b Chair, and supports and advises the Area 12b Chair during his/her two year term as necessary.

18. Area 12b Leadership Roles • Area 12b Chair • The Area 12b Chair leads all Area 12b activities, and has overall responsibility for ensuring all phases of programming for Area 12b. • Automatically assumes Area Chair position at the beginning of the annual (Fall) meeting in odd years after serving as Chair-Elect for two years. • Is responsible for selection of technical session topics in coordination with the Division Programming chair, and for finding chairs and co-chairs for these sessions.

19. Area 12b Leadership Roles • Area 12b Chair Cont’d. • Coordinates and helps session chairs in organizing sessions and meeting deadlines. • Develops the Area in accordance with the Area Mission Statement. • Holds Area meetings at least once a year at the Annual or Spring Meeting. • Holds an Area election at the Steering Committee meeting upon leaving office for the incoming Activities Chair position before handing over responsibilities to the Chair-Elect. • Provides leadership and management for the Area.

20. Area 12b Leadership Roles • Area 12b Chair-Elect • The Area 12b Chair-Elect prepares for the office of Chair by assisting the Area 12b Chair during his/her two year term. • Deputizes for the Area 12b Chair in the Chair's absence or inability to serve. • Automatically assumes the position of Area 12b Chair at the beginning of the annual (Fall) meeting in odd years after serving for two years as Area 12b Chair-Elect. • Formulates long-term plans and strategic activities for the Area in accordance with the Area Mission Statement. • Assist session chairs and co-chairs with finding presenters for 12b sessions.

21. Area 12b Leadership Roles • Area 12b Activities Chair • The Area 12b Activities Chair prepares for the office of Chair-Elect during his/her two year term. This position requires no prior experience in AIChE/PD Division or Area matters. • Is recruited by the outgoing Area 12b Chair-Elect, and is elected to office during Area Elections at the annual (Fall) meeting in odd years. • Automatically assumes the position of Area 12b Chair-Elect at the annual (Fall) meeting in odd years after serving for two years as Area 12b Activities Chair. • Assist session chairs and co-chairs with finding presenters for 12b sessions.

22. Spring 2008, New OrleansAIChE-Led joint ACS program Process Chemistry and Catalysis in Pilot Plants and Process Development ‡ Chemists in Process Development ‡ What Chemical Engineers Should Know about Chemistry ‡ What Chemists Should Know about Chemical Engineers ‡ Possible new session combining last 3: Chemists and Chemical Engineers: A powerful team for Process Development (submit title and abstract to any of 3 listed)

23. Spring 2008 New Orleans AREA: Process Research and Innovation (12a) 12A00 Innovations in Gas to Liquids 12A01 Process Innovations for Alternative Energy (1)12A02 Innovations in Catalyst Development (0) AREA: Pilot Plants (12b) 12B00 Current Challenges in Pilot Plant Operation (0)12B02 Gasification and Pyrolysis Pilot Plants (0) AREA: Technology Transfer (12c) 12C03 Challenges in Scale-up of Fuel Processes (0)12C04 Transfer of Ethylene Technology in the Middle East (0) AREA: Manufacturing (12d) 12D00 Plant Troubleshooting and Problem Solving: The Chemist and Engineer Working Together (3)12D00 Process Heat and Steam Traps (0)

24. Spring 2008 New Orleans GROUP: Topical 5: IMRET-10: 10th International Conference on Microreaction Technology (T5) T5000 Fine Chemicals and Pharmaceuticals Synthesis and Production - Part 1 (1) T5001 Fine Chemicals and Pharmaceuticals Synthesis and Production - Part 2 (0) T5002 Polyreactions (0) T5003 Catalyzed and Enzymatical Processes (0) T5004 Energy Generation and Fuel Processing (0) T5005 Multiphase Reactions, Dispersions and Foams (0) T5006 Particles and Functional Materials (1) T5007 Separation (1) T5008 Characterization and Simulation (0) T5009 Mixing, Mass Transfer and Heat Exchange (1) T5010 Sensing and Process Analytics (0) T5011 Novel Process Windows - Unusual Ways of Processing (0) T5012 Progress in the Commercialization of Micro Process Technology - Panel Discussion (0) T5013 Micro Process Engineering Poster Session (0)

25. AIChE PROCESS DEVELOPMENT DIVISION Salt Lake City PDD Mtgs • Sun. 11/4 at 5:30-7:00 PM – Steering Committee Meeting • Mon. 11/5 at 11-noon; 12a mtg - Karl (or Sagar) will run the mtg with the PDD projector • 12e mtg - Ron Besser and/or Kurt will run the mtg • 12f mtg - Lawrence will run the mtg • Tues. 11/6 at 11-noon; 12b mtg – Joe Powell will run the mtg with the PDD projector • 12c mtg – Osman will run the mtg • 12d mtg – Jon Worstell will run the mtg • Tues. 11/6 at 5:45-7:00 PM – Division Meeting (followed by PDD dinner) • Wed. 11/7 at 11-noon; 12g mtg - Michael Hill will run the mtg with the PDD projector

26. AIChE PROCESS DEVELOPMENT DIVISION Salt Lake City PDD Dinner Buca di Beppo Tues. November 6th, 2007 Guests start to arrive @ 7:00pm Dinner to be served @ 7:30 pm (see separate menu)