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Chlorhexidine An antiseptic bisguanide By Pharmaffiliates

Chlorhexidine and related impurities – role of Pharmaffiliates<br>

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Chlorhexidine An antiseptic bisguanide By Pharmaffiliates

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  1. ChlorhexidineAn antiseptic bisguanide By Pharmaffiliates

  2. Chlorhexidine - Introduction • Antibacterial and antiseptic drug • Belongs to Bisguanides family • Efficacious against gram-negative, gram-positive bacteria and yeasts. • Exists as cationic polybiguanide • Used as diacetate or dihydrochloride salts

  3. Chlorhexidine-Medical uses • Disinfectant of skin and hands • Additive to creams, toothpaste, deodorants • Preservative in eye drops • In root canal irrigation in dental surgeries. • A germicidal mouthwash

  4. Chlorhexidine-Mode of action • Chlorhexidinecation binds to the negatively charged bacterial cell wall. • Bacteriostatic at low concentration • Bactericidal at high concentration

  5. Chlorhexidine and related impurities – role of Pharmaffiliates • Process related impurities are identified, characterized and isolated at Pharmaffiliates • Identified as - Chlorhexidinediacetate impurity A, B, C, D, E, F, G, H, K, M, N, O, P.

  6. Chlorhexidine impurities Classification • Chlorhexidinediacetate impuritiesA, B, C, D, G,H, M, N, P - Impurities in the commercial preparation of Chlorhexidine. • Chlorhexidinediacetate Impurity F (N-(4-chlorophenyl)-urea) - Degradation product of Chlorhexidine in alkaline condition. • Chlorhexidinediacetate Impurity K - Found in a study of the kinetics of Chlorhexidine hydrolysis. • Chlorhexidinediacetate Impurity P (4-Chloroaniline)- Main degradation product of Chlorhexidine.

  7. Chlorhexidine and related impurities – Role of Pharmaffiliates • All impurity standards are available pack size of 25mg and 50mg • Competitive prices • Customized pack sizes are available • Complete structure elucidation and data interpretation • NMR, MASS and Chromatographic purity along with detailed Certificate of Analysis.

  8. ThankYou FOR MORE DETAILS ABOUT PRODUCT VISIT https://pharmaffiliates.com/ YOU CAN ALSO ORDER THIS BY FILLING QUICK ENQUIRY FORM AT https://www.pharmaffiliates.com/send-enquiry

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