1 / 9

The multiple challenges of Type 2 diabetes management

The multiple challenges of Type 2 diabetes management. Type 2 diabetes – a majority of patients worldwide fail to reach HbA 1c goals.

Jimmy
Download Presentation

The multiple challenges of Type 2 diabetes management

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. The multiple challenges of Type 2 diabetes management

  2. Type 2 diabetes – a majority of patients worldwide fail to reach HbA1c goals 1. De Pablo-Velasco, P et al. Poster presented at: 46th EASD Meeting; September 20–24, 2010; Stockholm, Sweden.;2. Wong ND, et al. Presented at: American Diabetes Association 70th Scientific Sessions; June 25–29, 2010; Orlando, FL; 3. Harris SB, et al. Diab Res ClinPract 2005;70:90–7: 4. Díaz-Apodaca BA, et al. Rev Panam SaludPublica 2010;28:207–13.

  3. Type 2 diabetes – increasingly challenging to control over time OAD =oral antidiabetic. UK Prospective Diabetes Study (UKPDS) Group. Lancet.1998;352:854–65; Campbell W. Br J Cardiol 2000;7:625–31; KhatibOMN, ed. EMRO Technical Publications Series 32. World Health Organization; 2006.

  4. Type 2 diabetes – most EU patients are overweight, have hypertension, or have dyslipidaemia1–3 1. European Public Health Alliance Web site. Obesity and diabetes. National Obesity Forum Annual Conference (last modified 2009). http://www.epha.org/a/3671. Accessed December 13, 2010; 2. Mancia G. ActaDiabetol2005;42(suppl 1):S17–S25; 3. Isomaa B, et al. Diabetes Care 2001;24:683–9.

  5. Type 2 diabetes – insulin and some oral antidiabetic therapies are associated with weight gain over time These trials have shown weight gain over time: • UKPDS, where there was a significant mean increase of 3.1 kg in weight in the intensive treatment (sulphonylurea or insulin) group compared with the conventional treatment (diet and exercise) group1 • Patients gained an average of 1.7 kg over 10 years of intensive treatment with glibenclamide1 • Patients gained up to 8 kg after 12 years of insulin therapy2 • Action to Control Cardiovascular Risk in Diabetes (ACCORD), where patients receiving intensive therapy (targeting an HbA1c <6%, often through the useof insulin and multiple agents) gained an average of 3.5 kg, with nearly 30% gaining >10 kg3 • In A Diabetes Outcome Progression Trial (ADOPT), patients receiving glibenclamide gained an average of 1.6 kg over a median treatment duration of3.3 years4 1. UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998;352:837–53; 2. UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998;352:854–65;3. Members of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Group. N Engl J Med 2008;358:2545–59; 4. Kahn SE, Haffner SM, Heise MA, et al.for the ADOPT Study Group. N Engl J Med 2006;355:2427–43.

  6. Type 2 diabetes – visceral adipose tissue (VAT) is a major cardiovascular risk factor 1. Carr DB, et al. Diabetes. 2004;53:2087–94; 2. Eeg-Olofsson K, et al. Diabetologia. 2009;52:65–73; 3. De Koning L, et al.Eur Heart J 2007;28:850–6.

  7. Type 2 diabetes can lead to severe consequences1–7 1. International Diabetes Federation. IDF Diabetes Atlas, 4th ed. Brussels, Belgium: International Diabetes Federation, 2009. 2. Hirsch LJ. Ask Dr. Hirsch: Cardiac autonomic neuropathy. http://www.bd.com/us/diabetes/page.aspx?cat=7001&id=19101. Accessed December 29, 2010; 3. Luchsinger JA, et al. Am J Epidemiol. 2001;154:635–41; 4. National Diabetes Information Clearing House (NDIC) Web site. Prevent diabetes problems: keep your feet and skin healthy. http://diabetes.niddk.nih.gov/dm/ pubs/complications_feet. Accessed December 9, 2010; 5. NDIC Web site. Sexual and urologic problems of diabetes. http://diabetes.niddk.nih.gov/dm/pubs/sup. Accessed December 9, 2010; 6. Wolosin JD, et al. Clin Diabetes. 2000;18:148. http://journal.diabetes.org/clinicaldiabetes/ v18n42000/pg148.htm. Accessed December 9, 2010; 7. NDIC Web site. Diabetes, heart disease and stroke. http://diabetes.niddk.nih.gov/dm/pubs/stroke/index.htm. Accessed December 9, 2010.

  8. Type 2 diabetes – a CVD risk equivalent Adapted frpm: Haffner SM, et al. N Engl J Med 1998;339:229–34.

  9. Summary • The majority of patients with Type 2 diabetes worldwide fail to control HbA1c • HbA1c becomes increasingly difficult to control with time • Type 2 diabetes is also associated with comorbidities such as hypertension, obesity and dyslipidaemia and these can lead to severe consequences

More Related