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Training

Training. Essential nutrients for your health. What is a Food Supplement?. Contents. Key message Introduction Product information Key benefits Target groups Posology & administration Calcium d eficiency Bone h ealth and o steoporosis Good to k now Complementary treatment

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Training

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  1. Training Essential nutrients for your health

  2. Whatis a Food Supplement?

  3. Contents Key message Introduction Product information Key benefits Target groups Posology & administration Calcium deficiency Bone healthandosteoporosis Good to know Complementary treatment References

  4. 1. Key message Bone mass is often thought to resemble a bank account in which deposits persist indefinitely. It is widely assumed that the foundation for a life with strong bones is established during growth phase and that bone mass acquisition in childhood and adolescence is an important determinant of bone health in late adulthood. supports the body with calcium in life stages where it is needed the most, like growth, pregnancy & breastfeeding, after menopause or during physical exercise

  5. 2. Introduction • Calcium is the most abundant mineral in the body. 1, 2 • Besides its fundamental role in bone metabolism, it is required for: 1, 2 • Vascular contraction and vasodilatation • Muscle function • Nerve transmission and intracellular signaling • Hormonal secretion • Maintenance of the heart beat

  6. 2. Introduction • Less than 1 % of body calcium is needed to support these metabolic • functions and is found in the blood. 3 • 99 % of the body‘s calcium supply is stored in bones and teeth where it supports their structure and function. 3 • Vitamin D supports calcium absorption by the human body. It is converted to calcitriol (active vitamin D) which promotes intestinal calcium absorption. 3

  7. 3. Product information

  8. 3. Product information * Growth period, pregnancy & breastfeeding, athletic and elderly people, lack of dietary intake, certain medications , postmenopausal women

  9. 4. Key benefits • Very good compliance – only 1 effervescent tablet per day • Easy consumption without swallowing tablets → ideal for children/adolescents • Fruity orange flavor • Beneficial to the maintenance of bones, teeth and contribution to a normal muscle function • Lactose free • Gluten free

  10. 5. Target group FAST CALCIUM SUPPLY FOR 3 Pregnancy & Breastfeeding Sport Growth phase Lack of calcium intake through nutrition / medication Postmenopausal women Elderly people

  11. 5. Target group FAST CALCIUM SUPPLY FOR 3, 4 Pregnancy & Breastfeeding • Fetal calcium requirement reaches its maximum during the 3rd trimester. • Recommended Dietary Allowances for pregnant and breastfeeding women are 1300 mg/day (14 – 18 years) or 1000 mg/day (19 – 50 years).

  12. 5. Target group FAST CALCIUM SUPPLY FOR 3 • Especially in periods of growth children and adolescents require calcium to build bones and teeth. • Up to 90% of peak bone mass is acquired by age 18 in girls and by age 20 in boys. • Additional calcium can be given in case of medical advice. Growth phase

  13. 5. Target group FAST CALCIUM SUPPLY FOR 3, 5 Athletic people • Athletic performance is supported by a sufficient calcium supply. • Calcium is an important mineral that • strengthens bones • improves muscle contraction • helps avoiding muscle cramps

  14. 5. Target group FAST CALCIUM SUPPLY FOR 3, 6, 7 Lack of calcium intake through nutrition / medication • More than 75% of the population worldwide is lactose intolerant • → risk of calcium inadequacy if they avoid dairy products • Cow’s milk allergy is affecting 0.6% - 0.9% of the population • → higher risk of insufficient calcium intake due to inability consume any dairy products e.g. in case of lactose intolerance or diets, proton-pump inhibitors, diuretics etc.

  15. 5. Target group FAST CALCIUM SUPPLY FOR 3 Elderly people Postmenopausal women As we grow older calcium absorption is naturally decreased. Menopause leads to reduced circulating estrogen levels and therefore decreased calcium absorption.

  16. 5. Target group FAST CALCIUM SUPPLY FOR3, 8 Vegetarians • Vegetarians are at risk of consuming less calcium than non-vegetarians. • They consume more plant products containing oxalic and phytic acid. • These acids decrease the intestinal absorption of calcium.

  17. 6. Posology & administration • INTAKE • The recommended intake is 1 effervescent tablet per day taken with a meal. • If a higher dosage is necessary, the recommended intake is 1 effervescent tablet in the morning and 1 in the evening (→ higher absorption if consumed separately). INGREDIENTS

  18. 7. Calcium deficiency • Inadequate intakes of dietary calcium produce no obvious symptoms in the short term. 3 • In the long term inadequate calcium intakes cause hypocalcemia which if untreated can lead to osteoporosis. 3 • Symptoms of hypocalcemia: 3 • Numbness • Tingling in the fingers and toes • Muscle cramps (in legs or arms) • Convulsions • Lethargy • Poor appetite • Abnormal heart rhythm

  19. 7. Calcium deficiency • People with proven or high risk of developing calcium deficiency: 3 • Diets low in calcium • High consume of alcoholic beverages, caffeine, tea • Intake of specific medications • Steroids • Barbiturates • Phenytoin • L-Thyroxine • Hypogonadism inducing drugs • Long-term use of anticoagulants • Proton-pump inhibitors • Thiazolidinediones (diabetes) • Chronic lithium therapy

  20. 8. Bone healthandosteoporosis • Two types of bone cells are mainly involved in bone metabolism: 9 1. Osteoclast:A type of bone cells that resorbs bone using acid and enzymes. 2. Osteoblast:A type of bone cell that is responsible for the production of bone and bone formation. Bone resorption Bone formation • Bone itself undergoes continuous remodeling with constant resorption and disposition of calcium into new bone.

  21. 8. Bone healthandosteoporosis • During childhood, bone formation outpaces resorption as growth proceeds. • After skeletal maturity is reached, bone resorption and formation maintain an approximate balance. 3 • The balance between bone resorption and deposition changes with age → osteoporosis can develop, when bone resorption exceeds bone formation Calcium Osteoblasts: creatingbone Osteoclasts: destroyingbone Calcium

  22. 8. Bone healthandosteoporosis • What is osteoporosis? 3 • Disorder characterized by porous and fragile bones • When calcium intake is low or ingested calcium is poorly absorbed, bone breakdown occurs as the body uses its stored calcium to maintain normal biological functions. • Bone loss also occurs as part of the normal aging process. • The loss of bones occurs silently and progressively. • Most associated with fractures of the hip, vertebrae, wrist, pelvis, ribs and other bones.

  23. 8. Bone healthandosteoporosis • Factors that increase the risk of developing osteoporosis: 3 • Female sex (esp. in postmenopausal women) • Advanced age (in both men and women) • Thin, inactive women • Smoking cigarettes • Excessive amounts of alcohol • Family history of osteoporosis • In men, a decrease in testosterone levels has comparable (but less pronounced) effect • Some medications Take +

  24. 9. Good to know • Are there any special considerations if other supplements or medications are taken? • Calcium should be taken at least 2 hours before or after the following medications: • Iron supplement (e.g. ferro vital+ Denk) • Levothyroxine • Biphosphonate drugs (alendronate, ibandronate) • Certain antibiotics such as tetracyclines or quinolones

  25. 10. Complementary treatment INDICATION: Bone Health + + • Dietary Magnesium intake improves Calcium absorption • (Ratio Magnesium:Calcium = 1:2) • Improves Calcium absorption

  26. 11. References 1Miller GD (1999): The Role of Calcium In Prevention of Chronic Diseases. J Am Col Nutr. 18 (5): 371S-372S. 2Miller GD (2013): The Importance of Meeting Calcium Needs with Foods. J Am Col Nutr. 20 (2): 168S-185S. 3National Institutes of Health (2016): Calcium. Fact Sheets for Health Professionals. 4WHO (2013): Guideline: Calcium supplementation in pregnant women. 5Wagner B (2012): Calcium. Runner’s World. 6German Nutrition Society (2013): New Reference Values for Calcium. Ann NutrMetab. 63. 186-192. 7Bulhões AC (2007): Correlation between lactose absorption and the C/T-13910 and G/A-22018 mutations. Braz J Med Biol Res. 40. 1441-1446. 8National Institute of Arthritis and Muscosceletal and Skin Diseases (2015): Osteoporosis. Peak Bone Mass in Women. 9IOM (2011): Dietary Reference Intakes for Calcium and Vitamin D. Nat Academies Press.

  27. Join DenkPharma Our contributions to keeping you healthy: • affordable pharmaceuticals for your therapy • German high premium quality for tablets, sachets, packaging, studies, consultation, availability, support, etc… • raise awareness by conducting Check Up Days (blood glucose, blood pressure, cholesterol and triglyceride) • constantly enhancing the product portfolio

  28. HEALTHCARE MADE IN GERMANY since 1948

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