1 / 34

DermPath Diagnostics – February 2010 Board Review Orlando, Florida

DermPath Diagnostics – February 2010 Board Review Orlando, Florida. Case 1. 45 yo F with scarring alopecia. Case 1 - Discoid Lupus Erythematosus. Case 1 - Discoid Lupus Erythematosus. Case 1 - Discoid Lupus Erythematosus. Case 1 - Discoid Lupus Erythematosus.

Leo
Download Presentation

DermPath Diagnostics – February 2010 Board Review Orlando, Florida

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. DermPath Diagnostics – February 2010 Board ReviewOrlando, Florida

  2. Case 1 • 45 yo F with scarring alopecia.

  3. Case 1 - Discoid Lupus Erythematosus

  4. Case 1 - Discoid Lupus Erythematosus

  5. Case 1 - Discoid Lupus Erythematosus

  6. Case 1 - Discoid Lupus Erythematosus

  7. Interface Dermatitis Timothy M. Kilpatrick, M.D.

  8. Interface Dermatitis Two types: Vacuolar Lichenoid

  9. Interface Dermatitis, Vacuolar: • Lupus Erythematosus • Dermatomyositis • Lichen Sclerosus • Drug Eruption • Erythema Multiforme • Mucha-Habermann disease • Graft vs. host reaction • Fixed Drug Eruption • Porokeratosis

  10. Interface Dermatitis, Lichenoid: • Lichen Planus • Lichen Planus-like Drug Eruption • Lichen Planus-like Keratosis • Mucha-Habermann Disease • Lichen Striatus • Graft vs Host • Lichenoid Purpura • Porokeratosis • Mycosis Fungoides, Patch Stage

  11. Lupus Erythematosus Interface / Vacuolar Prototype

  12. Clinical Features • Male to female ratio is 1:6 • Most common in childbearing years • Cutaneous only lupus erythematosus has male to female of 1:3 • Systemic LE is 4 times higher in African-American women than Caucasian women • African-American patients have higher incidence of nephritis, pneumonitis and discoid lesions

  13. Clinical Subtypes: • Discoid • Subacute • Systemic • Neonatal • Bullous • Panniculitis (Lupus Profundus) • Tumid Type

  14. Discoid LE

  15. Systemic LE

  16. Subacute Cutaneous LE

  17. Neonatal LE

  18. Tumid Type LE

  19. Lupus Profundus

  20. Histologic Features • Prototype interface dermatitis- vacuolar pattern • Discoid lesions have superficial & deep perivascular and periadnexal lymphocytes • Necrotic basilar keratinocytes • Scant parakeratosis with follicular plugging (in discoid lesions) • Thickened basement membrane zone (highlighted by PAS stain) • Excess dermal mucin • Direct immunofluorescence pattern: broad band of IgG and/or C3 basement membrane zone

  21. Discoid Lupus Erythematosus

  22. Discoid Lupus Erythematosus

  23. Discoid Lupus Erythematosus

  24. Discoid Lupus Erythematosus

  25. Tumid LE

  26. Tumid LE

  27. Tumid LE

  28. Porokeratosis

  29. Porokeratosis

  30. Porokeratosis

  31. Pityriasis lichenoides chronica

  32. Pityriasis lichenoides chronica

  33. Pityriasis lichenoides chronica

  34. Pityriasis lichenoides chronica

More Related