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Principles of Mechanical Ventilation

. Origins of mechanical ventilation. Negative-pressure ventilators (

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Principles of Mechanical Ventilation

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    1. Interesting to compare the viewpoints and biases of medicine/endocrinology articles, and the surgery articlesInteresting to compare the viewpoints and biases of medicine/endocrinology articles, and the surgery articles

    2. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    3. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    4. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    5. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    6. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    7. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    8. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    9. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    10. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    11. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    12. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    13. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    14. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    15. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    16. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    17. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    18. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    19. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    20. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    21. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    22. Disorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsDisorders characterized by systemic effects of M protein, and direct effects of bone marrow infiltration Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

    23. This concept is hugely important in cancer in that methylation silencing genes is equivalent to a mutation Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressorsThis concept is hugely important in cancer in that methylation silencing genes is equivalent to a mutation Common examples of methylation-induced silencing: Imprinted genes (Prader-Willi, Angelmann Syndromes) Inactivated 2nd X chromosome in females DNA methylation results in histone deacetylation, compacted chromatin, and repression of gene activity Methylation can have a profound effect in tumorigenesis by silencing tumor suppressors

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