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Optimizing parameters of a computational heart model to help develop improved pacing protocols in cardiac resynchronizat

Computational Cardiac Mechanics Modeling. Optimizing parameters of a computational heart model to help develop improved pacing protocols in cardiac resynchronization therapy . Heather Griffith. Monash University in Melbourne, Australia August 17, 2007. So basically….

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Optimizing parameters of a computational heart model to help develop improved pacing protocols in cardiac resynchronizat

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  1. Computational Cardiac Mechanics Modeling Optimizing parameters of a computational heart model to help develop improved pacing protocols in cardiac resynchronization therapy Heather Griffith Monash University in Melbourne, Australia August 17, 2007

  2. So basically… The goal of this research project is to explore how changing 2 existing default parameters on a cardiac model (the time-to-peak strain and the relaxation duration) affects the model behavior- specifically the dp/dtmax, dp/dtmin, and ejection fraction. The model is used to test different types of CRT (Cardiac Resynchronization Therapy) in order to improve treatments for people with heart failure. Understanding the relationship between these two parameters and overall hemodynamic functions of the heart may help expand the ability of the model to test varying heart conditions with greater accuracy.

  3. Research Progress • Found some error in the python script used to run the Continuity models, because certain files needed to analyze regional stress/strain were not created • Had 2 VTC’s, one with Roy and Fred and another with Slavisa and Fred, to adjust Continuity so that it will run on more resources • Changed the existing script so that it will run on one CPU (required changing parallel settings) • Started running Continuity jobs on Nimrod, now that it can run on any submission system (Continuity is no longer creating submission files)

  4. Research Progress (cont’d) • Gained access to more resources (Chile, Malaysia, and Japan) • Continued looking at differences in global functions of heart between the 5 models • Prepared PowerPoint presentation of my research project and progress so far • Gave a seminar (with the other PRIME students) to Monash University about our research • Received the script for varying parameters, adjusted it to work with Nimrod, and wrote a plan file to run it on Nimrod

  5. Future Goals • Start running the actual parameter sweeps of the two parameters on Nimrod (100 jobs) • Find the error in the python script which is causing certain stress/strain files to not be written • Write a script which will communicate to Continuity which nodes are available to use, so that Continuity will run on multiple nodes per resource, making computations much faster • Continue to research more about the specific parameters being varied to understand their relation to heart function • Have a blast in New Zealand after next week!

  6. Melbourne Culture City Lights Sovereign Hill Public Baths V-line Train

  7. We Love Monash!

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