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HIV

HIV GENOME. GENETIC INFORMATION - RNA - RIBONUCLEIC ACIDGENOME - SET OF INSTRUCTIONS IN RNA TO MAKE HIV. HIV GENES. STRUCTURAL [3]GAG - COREPOL - RT - REVERSE TRANSCRIPTASEENV - ENVELOPE - COATREGULATORY [6]TAT, REV, NEF, VIF, VPI, VPU. HIV INFECTION CYCLE. I - ATTACHMENT/ENTRYII - REVERSE TRANSCRIPTIONIII - DNA INTEGRATIONIV - REPRODUCTION OF HIV.

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HIV

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    1. HIV STRUCTURE INFECTION CYCLE

    3. HIV GENOME GENETIC INFORMATION - RNA - RIBONUCLEIC ACID GENOME - SET OF INSTRUCTIONS IN RNA TO MAKE HIV

    4. HIV GENES STRUCTURAL [3] GAG - CORE POL - RT - REVERSE TRANSCRIPTASE ENV - ENVELOPE - COAT REGULATORY [6] TAT, REV, NEF, VIF, VPI, VPU

    6. HIV INFECTION CYCLE I - ATTACHMENT/ENTRY II - REVERSE TRANSCRIPTION III - DNA INTEGRATION IV - REPRODUCTION OF HIV

    8. HIV LIFE CYCLE http://hopkins-aids.edu/hiv_lifecycle/hivcycle_txt.html

    9. I - ATTACHMENT/ENTRY HIV COAT PROTEIN GP 120 CELL COAT PROTEINS CD4 - RECEPTOR CCR-5 - CORECEPTOR

    10. II - REVERSE TRANSCIPTION HIV RNA COPIED TO HIV DNA RT - REVERSE TRANSCRIPTASE ENZYME

    11. III - HIV DNA INTEGRATION HIV DNA TO CELL’S DNA INTEGRATED HIV = HIV PROVIRUS CELL PERMANENTLY INFECTED

    12. IV - HIV INFECTION ACTIVE - GENE EXPRESSION AND VIRUS ASSEMBLY - RELEASE OF THOUSANDS OF HIV, CELL DIES INACTIVE - LATENT - NO GENE EXPRESSION TROJAN HORSE - VECTOR FOR HIV SPREAD THROUGHOUT BODY AND FOR LATER PRODUCTION OF HIV

    13. IMMUNE SYSTEM MACROPHAGES - INGEST, DIGEST AND DISPLAY FOREIGH BACTERIA, VIRUSES,… - BECOME ANTIGEN PRESENTING CELL [APC] APC NOTIFIES CD4 T CELL, T4 CELL T4 CELL - “CONDUCTOR” OF IMMUNE NOTIFY B AND T8

    15. B CELLS PRODUCE ANTIBODY ANTIBODY LEADS TO KILLING OF FREE VIRUS

    16. T8 CELLS T8 CELLS BECOME T-KILLER CELLS T-KILLER CELLS KILL HIV INFECTED CELLS

    18. HIV AND IMMUNODEFICIENCY HIV INFECTS AND KILLS T4 CELLS T4 = CONDUCTOR HIV ACTIVE AND PROGRESSIVE - KILLS UP TO 1 BILLION T4 CELLS PER DAY PER 10 YEARS

    19. HIV AVOIDS IMMUNE CLEARANCE MUTATION - INFECTION BY 1, TO THOUSANDS OF TYPES - “SWARM” - CHANGE COAT - EVADE IMMUNE HIV SANCTUARIES CELLULAR - INACTIVE PROVIRUS ANATOMICAL - CNS

    20. VARIABILITY IN OUTCOME RAPID/TYPICAL/NON-PROGRESSOR INDIVIDUAL VARIATION RESISTANCE TO INFECTION VIRAL VARIATION STRONG/WEAK STRAINS

    22. RESISTANCE TO INFECTION CCR-5 - HIV-1 CO-RECEPTOR DCCR-5 - HIV-1 CAN’T ATTACH MUTANT [DCCR5 GENE] 2 - RESISTANT TO INFECTION 1 - SLOWS INFECTION/PROGRESSION 0 - NORMAL INFECTION

    24. WEAK HIV STRAIN SYDNEY BLOOD BANK - SYDNEY COHORT - 1 MALE BLOOD DONOR - HIV+ - ‘81-84 DONOR + 6 TRANSFUSION RECIPIENTS - ASYMPTOMATIC, STABLE T4 CELL NUMBER, LOW VIRAL LOAD, 10 - 14 YEARS ATTENUATED - SIMILAR TO SIV D 3

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