2 Pharmacokinetics - Membrane transport

May 31, 2018

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2 Pharmacokinetics - Membrane transport

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Membrane Transport

Membrane Transport. Plant Physiology UNI. Two requirements. Route through the membrane Energy to move substances. Energy – 2 ways. Passive Energy already there (energy difference) Don’t need to add Active “Uphill” movement (energetically) Need to add energy

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Membrane Transport

Membrane Transport. Diffusion. With concentration gradient Unequal amounts of particles Movement of particles From high To Low. Dynamic Equilibrium. Equal concentrations are reached Not the same volumes Continued movement across the membrane Not gain or loss. Osmosis.

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Membrane Transport

Membrane Transport. Membrane Transport. What are some substances commonly transported across membranes?. Membrane Transport. What are the three mechanisms used to move solute molecules across the membrane?. Simple Diffusion. What is involved in this transport process?

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Membrane Transport

Membrane Transport. Chapter 11. Transcellular transport of glucose. The Na + - K + pump is an ATPase. Response of red blood cells to changes in osmolarity of extra cellular fluids. Distribution of phospholipids and glycolipids in the lipid bilayer of human red blood cells.

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Membrane Transport

Membrane Transport. Chp. 3, 5. Fluid compartments Membrane structure Movement of electrolytes other solutes and water - Passive transport - Active transport Chemical equilibrium Electrical equilibrium The membrane potential. Outline. Body Fluid Compartments. Figure 3-2.

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MEMBRANE TRANSPORT

MEMBRANE TRANSPORT. LECTURE-----4 DR ZAHOOR ALI SHAIKH. MEMBRANE TRASPORT. Plasma membrane is selectively permeable that means it allows some particles to pass while other can not pass. Things which can pass through Plasma membrane easily are:

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Membrane transport

Membrane transport. Biology 1. Molecules move from high to low. Diffusion move from HIGH to LOW concentration. Diffusion. Move from HIGH to LOW concentration passive transport no energy needed. diffusion of water. diffusion. osmosis. Simple Diffusion (through the cracks) .

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Membrane Transport

Membrane Transport. Chapter 6. Take in nutrients O 2 energy substrates building materials cofactors. Dispose of wastes CO 2 Urea. Cells Need to Exchange Materials with the Extracellular Fluid. Cells Must Control Movements of Materials. Need to maintain complexity inside the cell

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Membrane Transport

Membrane Transport. Plasma membranes are selectively permeable Some molecules easily pass through the membrane; others do not. Types of Membrane Transport. Passive processes No cellular energy (ATP) required Substance moves down its concentration gradient Active processes

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Membrane transport

Membrane transport. Chemistry 256. Types of ion channels (passive transport). Mechanosensitive channels – touch, sound, osmotic pressure changes Ligand-gated channels – external chemical signal (neurotransmitter) Signal-gated channels – internal chemical signal (Ca 2+ )

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Membrane Transport

Membrane Transport. Passive Transport . The movement of materials across a cell membrane without the use of energy (ATP) Movement of particles along a concentration gradient  from an area of higher concentration to an area of lower concentration (WITH a concentration gradient). Diffusion.

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Membrane Transport

Membrane Transport. Cells need to move substances both in and out (of the cell) The transport of water and other types of molecules across membranes is the key to many processes in living organisms Permeable membrane – allows substances through

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Membrane Transport

Membrane Transport. Lion Den Slide Collection By Kevin Patton User Manual Click each slide to advance it. Passive Transport. Requires no metabolic energy provided by the cell. Diffusion reduces or eliminates a concentration gradient. Collisions of particles spread the particles out.

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Membrane Transport

Membrane Transport. Δ G of Transport. Using a concentration gradient only: Assume that “A” is 0.05 mM extracellular and that a 15 mM intracellular concentration is desired at 37 o C. Calculate the free energy of movement of 1 mole of “A” from outside to inside the cell.

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Membrane Transport

Membrane Transport. Structure of Biological Membranes Diffusion and Fick’s First Law Partition Coefficients and Movement Osmosis and Osmotic Movement Charge Gradients Across the Membrane Donnan Equilibrium Passive Transport Straight Diffusion Facilitated Diffusion -- Cystic Fibrosis

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Membrane Transport

Membrane Transport. About Cell Membranes. All cells have a cell membrane Functions : Controls what enters and exits the cell to maintain an internal balance called homeostasis Provides protection and support for the cell. TEM picture of a real cell membrane.

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MEMBRANE TRANSPORT

MEMBRANE TRANSPORT. Bob Mercer rmercer@wustl.edu September 19, 2013. POLYCYSTIC RENAL DISEASE. 1 in 500 autopsies 1 in 3000 hospital admissions Accounts for ≈10% of end-stage renal failure Autosomal dominant inheritance. WILSON’S DISEASE.

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Membrane Transport

Membrane Transport. Xia Qiang （夏强） , PhD Department of Physiology Zhejiang University School of Medicine Tel: 88206861 Email: xiaqiang@zju.edu.cn. LEARNING OBJECTIVES. Describe how solutes cross cell membranes

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Membrane Transport

Membrane Transport. Definitions. Solution – mixture of dissolved molecules in a liquid Solute – the substance that is dissolved Solvent – the liquid. Membrane Transport Proteins. Many molecules must move back and forth from inside and outside of the cell

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