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1. POMALID 1MG DESCRIPTION Pomalid 1mg is a Natco pharma product which is endorsed by FDA, containing an active anti-cancer drug called pomalidomide. Pomalid 1mg is available as orally bioavailable thalidomide derivative with various therapeutic activities such as; Immuno modulatory Anti-angiogenesis Anti-neoplastic Pomalid 1mg is similar to thalidomide & Lenalidomide with related to decreased rate of serum aminotransferase elevations during treatment. This may leads to severe liver injury. Pomalid 1mg is involved in the treatment for regression & unmanageable multiple myeloma. Pomalid 1mg is used in the patients who are failing to response for Lenalidomide treatment. Pomalid 1mg is used in combination with dexamethasone. INDICATION The major therapeutic indication of Pomalid 1mg is involved in the treatment of multiple myeloma. This treatment is occurred by combining with dexamethasone for reducing the side effect associated with Pomalid 1mg Pomalid 1mg is majorly indicated in patients who are not reacts for prior two therapies like Lenalidomide & proteasome inhibitor. POMALID WORKS Pomalid 1mg exhibits various activities like; Anti-neoplastic activity Prohibits proliferation Promote apoptosis of hematopoietic cancer cells Co adjuvant with dexamethasone in both Lenalidomide sensitive & resistant myeloma cells to activate the tumor cell apoptosis Immuno modulatory Boosted the T-cells & natural killer cell mediate immunity. The drug is prohibited the formation of pro- inflammatory cytokines by monocytes. Anti-angiogenesis Interfere with formation of new vessels and leads to inhibit the cell division.

2. DOSAGE & ADMINISTRATION During hematological toxicities; Neutropenia : ANC (absolute neutrophils count) <500/mcl: Postpone the Pomalid therapy and provide CBC weekly ANC more than or equal to 500/mcl: Continue the Pomalid 3mg daily. Thrombocytopenia : Platelets count <25,000/mcL: postpone the Pomalid treatment & follow the CBC >50,000/mcL: continue 3mg of Pomalid Pomalid 1mg with potent CYP1A2 inhibitor : During this combination reduce the dose of Pomalid by 50% In renal impairment : Initial dose of Pomalid is 3mg In hepatic impairment : Mild to moderate condition, an initial dose of Pomalid is 3mg; in severe condition, the initial dose of Pomalid is 2mg. DRUG INTERACTION Pomalidomide metabolism is mediated by CYP1A2 & CYP3A4. The concomitant use of Pomalid 1mg with CYP1A2 drugs like Fluoxamine causes elevation of Cmax & AUC of Pomalidomide and concludes as increased concentration of Pomalid leads to higher extent of adverse effects associated with Pomalid In this condition, reduce the dose of Pomalid 1mg and recommended. STORAGE Pomalid 1mg should be stored at room temperature of 20° to 25° Protect from light Kept in dry & cool place