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Everotas contains of an active compound known as Everolimus which is interfere with development of cancer cell and process is slows down, this tablets is not a curable medication, which is helps to slow their spreading into the body.
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Apple Pharmaceuticals Presents
Everotas5mg 10mg Everolimus Tablets
DESCRIPTION Everotas is belongs to class of anti-cancer drugs Everotas contains of an active compound known as Everolimus which is interfere with development of cancer cell and process is slows down. Everotas tablets is not a curable medication, which is helps to slow their spreading into the body. PHARMACOLOGY OF EVEROTAS Everolimus is an prohibitor of mTOR, links at peak compatibility to FK506 binding protein 12, through producing drug complex which prevents the productive of mTOR. This inhibition reduces the activity of effectors downstream, which may lead to stoppage of cell progression from G1 into S phase, finally causes cell growth arrest and apoptosis. Everotas also prohibits the expression of hypoxia-inducible factor, causing to a reduces in the expression of vascular endothelial growth factor. The results of everolimus prevention of mTOR is a reduction in cell multiplication, angiogenesis, and glucose uptake.
DOSAGE Everotas tablets should be given with or without food. Dosage regimen of Everotas; In breast cancer, renal cell cancer, pancreatic cancer, Neuro endocrine cancer: The prescribed dosage is 10mg should be taken as a single dose. In Brain or intracranial cancer: The prescribed dosage of Everotas as a single dose. is 4.5mg/m2 given orally In pediatric: The pediatric dosage of Everotas as a single dose in brain or intracranial tumor is 4.5mg/m2 should be given orally. DRUG-DRUG INTERACTION Interaction of Everotas with strong inhibitor of CYP3A4, or P-gp, cause reducing the efflux of Everolimus and high plasma concentration of Everolimus. Concomitant use of Everotas with strong CYP3A4 inducers, will increasing the disclosure of Everolimus. Interaction of Everotas with cyclosporine will increasing the AUC level of Everolimus frequently.
PREGNANCY Pregnancy category of Everolimus C : In patients Everotas is used only after knowing the benefits to the mother exceed the risk to fetus. LACTATION Breast feeding should not be suggested. STORAGE Everotas tablet store at 25° Protect the medicine away from moisture, heat and light. MISSED DOSE If the patients missed dose, patients must consult with medical practitioner and follow the instructions given by them. Or missed dose should be avoid and follow the regular dosing schedule.
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