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Pomacel 4mg capsule - Pomalidomide | Myapplepharma

Pomacel 4mg is a Glenmark Pharmaceuticals product which is endorsed by FDA, containing an active anti-cancer drug called Pomalidomide, It is available as orally bioavailable thalidomide derivative with various therapeutic activities such as;Immuno modulatory, Anti-angiogenesis, Anti-neoplastic

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Pomacel 4mg capsule - Pomalidomide | Myapplepharma

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  1. POMACEL 4MG DESCRIPTION Pomacel 4mg is a Glenmark Pharmaceuticals product which is endorsed by FDA, containing an active anti-cancer drug called Pomacelomide. Pomacel 4mg is available as orally bioavailable thalidomide derivative with various therapeutic activities such as; Immuno modulatory Anti-angiogenesis Anti- neoplastic Pomacel 4mg is similar to thalidomide & Lenalidomide with related to decreased rate of serum aminotransferase elevations during treatment. This may leads to severe liver injury. Pomacel 4mg is involved in the treatment for regression & unmanageable multiple myeloma. Pomacel 4mg is used in the patients who are failing to response for Lenalidomide treatment. Pomacel 4mg is used in combination with dexamethasone. INDICATION The major therapeutic indication of Pomacel 4mg is involved in the treatment of multiple myeloma. This treatment is occurred by combining with dexamethasone for reducing the side effect associated with Pomacel 4mg Pomacel 4mg is majorly indicated in patients who are not reacts for prior two therapies like Lenalidomide & proteasome inhibitor. Pomacel WORKS Pomacel 4mg exhibits various activities like; Anti-neoplastic activity Prohibits proliferation Promote apoptosis of hematopoietic cancer cells Co adjuvant with dexamethasone in both Lenalidomide sensitive & resistant myeloma cells to activate the tumor cell apoptosis Immuno modulatory Boosted the T-cells & natural killer cell mediate immunity. The drug is prohibited the formation of pro- inflammatory cytokines by monocytes. Anti-angiogenesis Interfere with formation of new vessels and leads to inhibit the cell division.

  2. DOSAGE & ADMINISTRATION During hematological toxicities; Neutropenia : ANC (absolute neutrophils count) <500/mcl: Postpone the Pomacel therapy and provide CBC weekly ANC more than or equal to 500/mcl: Continue the Pomacel 3mg daily. Thrombocytopenia : Platelets count <25,000/mcL: postpone the Pomacel treatment & follow the CBC >50,000/mcL: continue 3mg of Pomacel Pomacel 4mg with potent CYP1A2 inhibitor : During this combination reduce the dose of Pomacel by 50% In renal impairment : Initial dose of Pomacel is 3mg In hepatic impairment : Mild to moderate condition, an initial dose of Pomacel is 3mg; in severe condition, the initial dose of Pomacel is 2mg. DRUG INTERACTION Pomacelomide metabolism is mediated by CYP1A2 & CYP3A4. The concomitant use of Pomacel 4mg with CYP1A2 drugs like Fluoxamine causes elevation of Cmax & AUC of Pomacelomide and concludes as increased concentration of Pomacel leads to higher extent of adverse effects associated with Pomacel In this condition, reduce the dose of Pomacel 4mg and recommended. STORAGE Pomacel 4mg should be stored at room temperature of 20° to 25° Protect from light Kept in dry & cool place

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