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Pomahope 1mg is a Glenmark Pharmaceuticals product which is endorsed by FDA, containing an active anti-cancer drug called Pomalidomide, It is available as orally bioavailable thalidomide derivative with various therapeutic activities such as;Immuno modulatory, Anti-angiogenesis, Anti-neoplastic
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POMALIDOMIDE POMAHOPE 1MG
DESCRIPTION Pomahope 1mg is a Natco pharma product which is endorsed by FDA, containing an active anti-cancer drug called Pomalidomide. Pomahope 1mg is available as orally bioavailable thalidomide derivative with various therapeutic activities such as; Immuno modulatory Anti-angiogenesis Anti-neoplastic Pomahope 1mg is similar to thalidomide & Lenalidomide with related to decreased rate of serum aminotransferase elevations during treatment. This may leads to severe liver injury. Pomahope 1mg is involved in the treatment for regression & unmanageable multiple myeloma. Pomahope 1mg is used in the patients who are failing to response for Lenalidomide treatment. Pomahope 1mg is used in combination with dexamethasone. • INDICATION • The major therapeutic indication of Pomahope 1mg is involved in the treatment of multiple myeloma. • This treatment is occurred by combining with dexamethasone for reducing the side effect associated with Pomahope1mg. Pomahope1mg is majorly indicated in patients who are not reacts for prior two therapies like Lenalidomide & proteasome inhibitor.
POMALID WORKS Pomahope 1mg exhibits various activities like; Anti-neoplastic activity Prohibits proliferation Promote apoptosis of hematopoietic cancer cells Co adjuvant with dexamethasone in both Lenalidomide sensitive & resistant myeloma cells to activate the tumor cell apoptosis Immuno modulatory Boosted the T-cells & natural killer cell mediate immunity. The drug is prohibited the formation of pro-inflammatory cytokines by monocytes. Anti-angiogenesis Interfere with formation of new vessels and leads to inhibit the cell division.
DRUG INTERACTION • Pomalidomide metabolism is mediated by CYP1A2 & CYP3A4. The concomitant use of Pomahope 1mg with CYP1A2 drugs like Fluoxamine causes elevation of Cmax & AUC of Pomalidomide and concludes as increased concentration of Pomahope leads to higher extent of adverse effects associated with Pomahope In this condition, reduce the dose of Pomahope 1mg and recommended. • STORAGE • Pomahope 1mg should be stored at room temperature of 20° to 25° Protect from light Kept in dry & cool place
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