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Pomalex 4mg capsule - Pomalidomide | Myapplepharma

Pomalex 4mg is a Glenmark Pharmaceuticals product which is endorsed by FDA, containing an active anti-cancer drug called Pomalidomide, It is available as orally bioavailable thalidomide derivative with various therapeutic activities such as;Immuno modulatory, Anti-angiogenesis, Anti-neoplastic

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Pomalex 4mg capsule - Pomalidomide | Myapplepharma

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  1. POMALEX 4MG DESCRIPTION Pomalex 4mg is a Natco pharma product which is endorsed by FDA, containing an active anti-cancer drug called Pomalidomide. Pomalex 4mg is available as orally bioavailable thalidomide derivative with various therapeutic activities such as; Immuno modulatory Anti-angiogenesis Anti-neoplastic Pomalex 4mg is similar to thalidomide & Lenalidomide with related to decreased rate of serum aminotransferase elevations during treatment. This may leads to severe liver injury. Pomalex 4mg is involved in the treatment for regression & unmanageable multiple myeloma. Pomalex 4mg is used in the patients who are failing to response for Lenalidomide treatment. Pomalex 4mg is used in combination with dexamethasone. INDICATION The major therapeutic indication of Pomalex 4mg is involved in the treatment of multiple myeloma. This treatment is occurred by combining with dexamethasone for reducing the side effect associated with Pomalex 4mg Pomalex 4mg is majorly indicated in patients who are not reacts for prior two therapies like Lenalidomide & proteasome inhibitor. Pomalex WORKS Pomalex 4mg exhibits various activities like; Anti-neoplastic activity Prohibits proliferation Promote apoptosis of hematopoietic cancer cells Co adjuvant with dexamethasone in both Lenalidomide sensitive & resistant myeloma cells to activate the tumor cell apoptosis Immuno modulatory Boosted the T-cells & natural killer cell mediate immunity. The drug is prohibited the formation of pro- inflammatory cytokines by monocytes. Anti-angiogenesis Interfere with formation of new vessels and leads to inhibit the cell division.

  2. DOSAGE & ADMINISTRATION During hematological toxicities; Neutropenia : ANC (absolute neutrophils count) <500/mcl: Postpone the Pomalex therapy and provide CBC weekly ANC more than or equal to 500/mcl: Continue the Pomalex 3mg daily. Thrombocytopenia : Platelets count <25,000/mcL: postpone the Pomalex treatment & follow the CBC >50,000/mcL: continue 3mg of Pomalex Pomalex 4mg with potent CYP1A2 inhibitor : During this combination reduce the dose of Pomalex by 50% In renal impairment : Initial dose of Pomalex is 3mg In hepatic impairment : Mild to moderate condition, an initial dose of Pomalex is 3mg; in severe condition, the initial dose of Pomalex is 2mg. DRUG INTERACTION Pomalidomide metabolism is mediated by CYP1A2 & CYP3A4. The concomitant use of Pomalex 4mg with CYP1A2 drugs like Fluoxamine causes elevation of Cmax & AUC of Pomalidomide and concludes as increased concentration of Pomalex leads to higher extent of adverse effects associated with Pomalex In this condition, reduce the dose of Pomalex 4mg and recommended. STORAGE Pomalex 4mg should be stored at room temperature of 20° to 25° Protect from light Kept in dry & cool place

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