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The 2nd most frequent kind of severe neurodegenerative condition is Parkinson's disease (PD), sometimes known as the "tremor disease." Dopaminergic neurons in the substantia nigra pars compacta (SNpc) gradually degenerate, which is one of the defining characteristics of this condition. About The neurobiological effects of a short peptide with 11 amino acid amidated peptide that was derived from the proGDNF domain and given the name dopamine neuron stimulating peptide-11 were described in a study (DNSP-11). Following a single injection of DNSP-11 into the substantia nigra of a normal adult rat, increases in resting dopamine levels and its metabolites were found in vivo 28 days after the injection. These rises were detected in the substantia nigra.