A-Ret Gel (Generic Tretinoin Gel)

1. A-Ret Gel (Generic Tretinoin Gel) © The Swiss Pharmacy

2. A-Ret Gel (Generic Tretinoin Gel) A-Ret Gel (Generic Tretinoin Gel) is a retinoid, which is used for topical treatment of acne vulgaris. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. It can’t erase deep wrinkles, but it can help improve the appearance of surface wrinkles, fine lines, and dark spots. © The Swiss Pharmacy

3. A-Ret Gel (Generic Tretinoin Gel) A-Ret Gel is manufactured by Akums Drugs & Pharmaceuticals Limited, India in the strengths of 0.025%, 0.05% and 0.1% . It is marketed by the trademark holder A. Menarini Asia-Pacific Holdings Pte. Ltd. © The Swiss Pharmacy

4. A-Ret Gel (Generic Tretinoin Gel) Chemical Structure © The Swiss Pharmacy

5. A-Ret Gel (Generic Tretinoin Gel) The active pharmaceutical ingredient present in A-Ret Gel is Tretinoin. A-Ret Gel contains Tretinoin in either of three strengths 0.025%, 0.05% or 0.1%. Each gram of A-Ret Gel contains 0.25 mg (0.025%), 0.5 mg (0.05%) or 1 mg (0.10%) Tretinoin in a translucent to opaque, pale yellow topical gel. © The Swiss Pharmacy

6. A-Ret Gel (Generic Tretinoin Gel) Uses of A-Ret Gel 0.025%, 0.05% and 0.1%: A-Ret Gel (Generic Tretinoin Gel) is used to treat acne or other skin diseases as determined by your doctor. It works partly by keeping skin pores clear. One of the Tretinoin creams is used to treat fine wrinkles, dark spots, or rough skin on the face caused by the damaging rays of the sun. It works by lightening the skin, replacing older skin with newer skin, and slowing down the way the body removes skin cells that may have been harmed by the sun. Tretinoin works best when used within a skin care program that includes protecting the treated skin from the sun. However, it does not completely or permanently erase these skin problems or greatly improve more obvious changes in the skin, such as deep wrinkles caused by the sun or the natural aging process. © The Swiss Pharmacy

7. A-Ret Gel (Generic Tretinoin Gel) Recommended Adult Dosage A-Ret Gel (Generic Tretinoin Gel) should be applied once a day, in the evening, before bedtime, to the skin where acne lesions appear, using enough to cover the entire affected area in a thin layer. Areas to be treated should be cleansed thoroughly before the medication is applied. If medication is applied excessively, no more rapid or better results will be obtained and marked redness, peeling, or discomfort may occur. A transitory feeling of warmth or slight stinging may be noted on application. In cases where it has been necessary to temporarily discontinue therapy or to reduce the frequency of application, therapy may be resumed or the frequency of application increased as the patient becomes able to tolerate the treatment. A-Ret Gel © The Swiss Pharmacy

8. A-Ret Gel (Generic Tretinoin Gel) Recommended Adult Dosage Frequency of application should be closely monitored by careful observation of the clinical therapeutic response and skin tolerance. Efficacy has not been established for less than once daily dosing frequencies. This medicine is not for oral, ophthalmic, or intravaginal use. Medical effect should be noticed after two to three weeks but more than six weeks of treatment may be required before definite beneficial effects are seen. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html © The Swiss Pharmacy

9. A-Ret Gel (Generic Tretinoin Gel) Contraindications ➔A-Ret Gel is contraindicated in patients with a known hypersensitivity to Tretinoin or any component of the gel. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html © The Swiss Pharmacy

10. A-Ret Gel (Generic Tretinoin Gel) Storage Instructions A-Ret Gel (Generic Tretinoin Gel) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html © The Swiss Pharmacy

11. A-Ret Gel (Generic Tretinoin Gel) Warnings A-Ret Gel (Generic Tretinoin Gel) should not be used on eczematous or sunburned skin due to potential for severe irritation. Topical over-the-counter acne preparations, concomitant topical medications, medicated cleansers, topical products with alcohol or astringents: Use with caution, irritation may occur. Avoid unprotected exposure to sunlight including sunlamps (UV light) when using Tretinoin Gel due to potential for increased photosensitization. Use sunscreen of at least SPF 15 and protective clothing during exposure. Avoid use of Tretinoin Gel with weather extremes, such as wind or cold due to potential for increased irritation. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html © The Swiss Pharmacy

12. A-Ret Gel (Generic Tretinoin Gel) Warnings Use Tretinoin Gel with caution if allergic to fish due to potential for allergenicity to fish protein. Patients who develop pruritus or urticaria should contact their healthcare provider. Avoid electrolysis, waxing and chemical depilatories for hair removal on the treated areas while using this medicine. Tell your doctor right away if you get sunburned or have skin blisters/redness. Wait until your skin has completely recovered from a sunburn before using A-Ret Gel (Generic Tretinoin Gel). URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html © The Swiss Pharmacy

13. A-Ret Gel (Generic Tretinoin Gel) Possible Side Effects The most common side effects with an incidence rate of 5% or more with Tretinoin Gel are dry skin, peeling/scaling/flaking skin, skin burning sensation, and erythema. During clinical trials for each concentration, acne subjects treated with Tretinoin Gel 0.1% or 0.04%, over the twelve week period showed that cutaneous irritation scores for erythema, peeling, dryness, burning/stinging, or itching peaked during the initial two weeks of therapy, decreasing thereafter. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html © The Swiss Pharmacy

14. A-Ret Gel (Generic Tretinoin Gel) Possible Side Effects Tell your doctor immediately if you experience: blistering, crusting, severe burning/swelling of the skin, eye redness and watering (conjunctivitis), eyelid swelling, skin discoloration. A very serious allergic reaction to A-Ret Gel is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html © The Swiss Pharmacy

15. A-Ret Gel (Generic Tretinoin Gel) Overdosage If medication is applied excessively, no more rapid or better results will be obtained and marked redness, peeling, or discomfort may occur. Oral ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of Vitamin A. In case marked erythema and skin inflammatory reactions occur, discontinue use of this medicine and if necessary, apply cold compresses and/or mild emollient. Symptoms of acute toxicity of this medicine would be of gastrointestinal disturbance. In such event, treatment such as gastric lavage, inducing emesis and/or forced fluids should be performed as soon as possible. © The Swiss Pharmacy

16. A-Ret Gel (Generic Tretinoin Gel) A-Ret Gel During Pregnancy Tretinoin Gel (A-Ret Gel) has been classified by the US FDA as Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Tretinoin Gel (A-Ret Gel) should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Thirty human cases of temporally associated congenital malformations have been reported during two decades of clinical use of Tretinoin Gel 0.1%. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html © The Swiss Pharmacy

17. A-Ret Gel (Generic Tretinoin Gel) A-Ret Gel A-Ret Gel (Generic Tretinoin Gel) is manufactured by Akums Drugs & Pharmaceuticals Limited, India and marketed by the trademark holder A. Menarini Asia- Pacific Holdings Pte. Ltd. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html https://www.theswisspharmacy.com/product_info.php?info=p9780_A-Ret-Gel.html © The Swiss Pharmacy