Amlopres Tablets (Generic Amlodipine Besylate Tablets)

1. Amlopres Tablets (Generic Amlodipine Besylate Tablets) © The Swiss Pharmacy

2. Amlopres Tablets (Generic Amlodipine Besylate Tablets) Amlopres (Generic Amlodipine Besylate Tablets) is used to treat high blood pressure (hypertension) by itself or in combination with other medicines. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to prevent certain types of chest pain (Angina). It may help to increase your ability to exercise and decrease the frequency of angina attacks. © The Swiss Pharmacy

3. Amlopres Tablets (Generic Amlodipine Besylate Tablets) Amlopres Tablets are manufactured by Cipla Limited, India in the strengths of 2.5 mg, 5 mg and 10 mg. © The Swiss Pharmacy

4. Amlopres Tablets (Generic Amlodipine Besylate Tablets) Chemical Structure © The Swiss Pharmacy

5. Amlopres Tablets (Generic Amlodipine Besylate Tablets) The active ingredient contained in Amlopres tablets is Amlodipine Besylate (Amlodipine Besilate). Each uncoated Amlopres tablet contains Amlodipine Besylate equivalent to 2.5 mg, 5 mg or 10 mg of Amlodipine. © The Swiss Pharmacy

6. Amlopres Tablets (Generic Amlodipine Besylate Tablets) Uses of Amlopres 2.5 mg, 5 mg and 10 mg Tablets: Amlopres (Amlodipine Besylate Tablets) is used alone or together with other medicines to treat hypertension (high blood pressure). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. Amlodipine is also used to relieve chronic stable angina (chest pain) or vasospastic angina (Prinzmetal's or variant angina). This medicine is also used to lower the risk of hospitalization for angina and heart surgery (eg, coronary revascularization) in patients with recently documented coronary artery disease (CAD) by angiography and without certain heart problems (eg, heart failure or an ejection fraction less than 40%). URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html © The Swiss Pharmacy

7. Amlopres Tablets (Generic Amlodipine Besylate Tablets) Uses of Amlopres 2.5 mg, 5 mg and 10 mg Tablets: Amlodipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. This relaxes the blood vessels and lowers blood pressure, and increases the supply of blood and oxygen to the heart while reducing its workload. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html © The Swiss Pharmacy

8. Amlopres Tablets (Generic Amlodipine Besylate Tablets) Recommended Adult Dosage For most patients, the starting dose of Amlopres tablets (Generic Amlodipine Tablets) for the treatment of Hypertension is 5 mg once daily, with a maximum dose of 10 mg once daily. Small, fragile or elderly individuals or patients with hepatic insufficiency may be started on 2.5 mg once daily and this dose may be used when adding Amlopres (Amlodipine Besilate) to other anti-hypertensive therapy. Amlopres tablets URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html © The Swiss Pharmacy

9. Amlopres Tablets (Generic Amlodipine Besylate Tablets) Recommended Adult Dosage Chronic Stable or Vasospastic Angina: The starting dose of Amlopres (Amlodipine Besilate) is 5mg to 10 mg with a lower dose (2.5 mg) in the elderly and in patients with hepatic insufficiency. The recommended dose range for patients with Coronary Artery Disease (CAD) is 5mg to 10 mg once daily. In clinical studies, the majority of patients required 10 mg. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html © The Swiss Pharmacy

10. Amlopres Tablets (Generic Amlodipine Besylate Tablets) Contraindications ➔Amlopres is contraindicated in patients with a known hypersensitivity to Amlodipine Besylate, other dihydropyridines or any component of the tablet. ➔Amlodipine is transferred into human breast milk, therefore Amlopres is contraindicated during breast-feeding. ➔Amlopres is also contraindicated in patients with severe hypotension, shock including cardiogenic shock, obstruction of the outflow tract of the left ventricle (e.g. high grade aortic stenosis) and haemodynamically unstable heart failure after acute myocardial infarction URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html © The Swiss Pharmacy

11. Amlopres Tablets (Generic Amlodipine Besylate Tablets) Storage Instructions Amlopres Tablets (Generic Amlodipine Besylate Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html © The Swiss Pharmacy

12. Amlopres Tablets (Generic Amlodipine Besylate Tablets) Warnings Symptomatic hypotension is possible, particularly in patients with severe aortic stenosis. However, acute hypotension is unlikely. Worsening angina and acute myocardial infarction can develop after starting or increasing the dose of Amlopres tablets particularly in patients with severe obstructive coronary artery disease. Titrate slowly in patients with severe hepatic impairment. No studies on the effects on the ability to drive and use machines have been performed. Patients who experience dizziness as an adverse reaction should avoid driving vehicles or using machines. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html © The Swiss Pharmacy

13. Amlopres Tablets (Generic Amlodipine Besylate Tablets) Possible Side Effects Most common Amlopres (Amlodipine Besilate) side effects are headache and edema which occurred in a dose related manner. Other side effects not dose related but reported with an incidence of more than 1.0% are headache, fatigue, nausea, abdominal pain, and somnolence URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html © The Swiss Pharmacy

14. Amlopres Tablets (Generic Amlodipine Besylate Tablets) Overdosage Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia. In humans, experience with intentional overdosage of Amlodipine Besylate (Amlodipine Besilate) is limited. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html © The Swiss Pharmacy

15. Amlopres Tablets (Generic Amlodipine Besylate Tablets) Treatment of Overdosage If massive Amlopres (Amlodipine tablets) overdose should occur, active cardiac and respiratory monitoring should be instituted. Frequent blood pressure measurements are necessary. Should hypotension occur, cardiovascular support including elevation of the extremities and the judicious administration of fluids should be started. If hypotension remains unresponsive to these conservative measures, administration of vasopressors (such as phenylephrine) should be considered with attention to circulating volume and urine output. Intravenous calcium gluconate may help to reverse the effects of calcium entry blockade. As Amlodipine is highly protein bound, hemodialysis is not likely to be of benefit. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html © The Swiss Pharmacy

16. Amlopres Tablets (Generic Amlodipine Besylate Tablets) Amlopres Tablets During Pregnancy Amlodipine Besylate (Amlopres tablets) has been classified by the US FDA as Pregnancy Category C. There are no adequate and well- controlled studies in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the risk to the fetus. During animal reproduction studies, there was no evidence of adverse developmental effects when pregnant rats and rabbits were treated orally with Amlodipine Besilate during organogenesis at doses approximately 10 and 20-times the maximum recommended human dose (MRHD), respectively. However for rats, litter size was significantly decreased (by about 50%) and the number of intrauterine deaths was significantly increased. © The Swiss Pharmacy

17. Amlopres Tablets (Generic Amlodipine Besylate Tablets) Amlopres Tablets Amlopres Tablets (Generic Amlodipine Besylate Tablets) are manufactured by Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html https://www.theswisspharmacy.com/product_info.php?info=p9491_Amlopres-Pills.html © The Swiss Pharmacy