Canesten Cream (Generic Clotrimazole Cream)

1. Canesten Cream (Generic Clotrimazole Cream) © The Swiss Pharmacy

2. Canesten Cream (Generic Clotrimazole Cream) Canesten Cream (Generic Clotrimazole Cream) is used to treat fungal skin infections such as ringworm, athlete's foot, fungal nappy rash and fungal sweat rash. It is also used to relieve irritation of the vulva (external thrush) or the end of the penis, which may be associated with thrush. © The Swiss Pharmacy

3. Canesten Cream (Generic Clotrimazole Cream) Canesten Cream is manufactured by Bayer Zydus Pharma Private Limited, India in the strength of 1%. © The Swiss Pharmacy

4. Canesten Cream (Generic Clotrimazole Cream) Chemical Structure © The Swiss Pharmacy

5. Canesten Cream (Generic Clotrimazole Cream) The active ingredient contained in Canesten Cream is Clotrimazole. Each gram Canesten Cream contains 10mg of Clotrimazole. © The Swiss Pharmacy

6. Canesten Cream (Generic Clotrimazole Cream) Uses of Canesten 1% Cream 15g: Clotrimazole topical preparations are used to treat fungus infections on the skin. Canesten Antifungal Cream is used to treat fungal skin infections such as ringworm, athlete’s foot, fungal nappy rash and fungal sweat rash. Canesten Cream (Generic Clotrimazole 1% Cream) is used for the treatment of: i. All dermatomycoses due to moulds and other fungi (e.g. Trichophyton species) ii. All dermatomycoses due to yeasts (Candida species). These include ringworm (tinea) infections (e.g. athlete's foot), paronychia, pityriasis versicolor, erythrasma and intertrigo. iii. Skin diseases showing secondary infection with these fungi. iv. Candidal nappy rash, vulvitis and balanitis. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html © The Swiss Pharmacy

7. Canesten Cream (Generic Clotrimazole Cream) How Does Canesten 1% Cream Work?: Clotrimazole (Canesten Cream) acts primarily by damaging the permeability barrier in the cell membrane of fungi. Clotrimazole brings about inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes. If ergosterol synthesis is completely or partially inhibited, the cell is no longer able to construct an intact cell membrane. This leads to death of the fungus. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html © The Swiss Pharmacy

8. Canesten Cream (Generic Clotrimazole Cream) Recommended Adult Dosage The dose of Canesten Cream Canesten Cream (Generic Clotrimazole Cream) is given below: Gently massage sufficient Clotrimazole cream into the affected and surrounding skin areas twice a day, in the morning and evening. Use the cream on your skin only. A strip of cream (0.5cm long) is enough to treat an area the size of your hand. It is best to use it for at least 2 weeks, even if all signs of the infection have gone, to stop it from coming back. It can be used for up to 4 weeks if needed. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html © The Swiss Pharmacy

9. Canesten Cream (Generic Clotrimazole Cream) Contraindications ➔Canesten Cream is contraindicated in patients with a known hypersensitivity to Clotrimazole or any component of the cream. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html © The Swiss Pharmacy

10. Canesten Cream (Generic Clotrimazole Cream) Storage Instructions Canesten Cream (Generic Clotrimazole Cream) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html © The Swiss Pharmacy

11. Canesten Cream (Generic Clotrimazole Cream) Warnings Canesten Cream (Generic Clotrimazole Cream) is not for ophthalmic use. If irritation or sensitivity develops with the use of Clotrimazole cream, treatment should be discontinued and appropriate therapy instituted. This product contains cetostearyl alcohol, which may cause local skin reactions (e.g. contact dermatitis). The patient should be advised to use the medication for the full treatment time even though the symptoms may have improved. Notify the physician if there is no improvement after four weeks of treatment. The patient should inform the physician if the area of application shows signs of increased irritation (redness, itching, burning, blistering, swelling, oozing) indicative of possible sensitization. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html © The Swiss Pharmacy

12. Canesten Cream (Generic Clotrimazole Cream) Warnings The patient should avoid the use of occlusive wrappings or dressings. The patient should avoid sources of infection or reinfection. Occlusive dressings should not be applied over Canesten 1% topical cream unless directed by a physician. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html © The Swiss Pharmacy

13. Canesten Cream (Generic Clotrimazole Cream) Possible Side Effects Large scale clinical studies have shown Canesten Cream (Generic Clotrimazole Cream) to be well tolerated after topical application. The side effects of Canesten cream are given below: Immune system disorders: allergic reaction (syncope, hypertension, dyspnea, urticaria) Skin and subcutaneous tissue disorders: blisters, discomfort/pain, edema, erythema, irritation, peeling/exfoliation, pruritus, rash, stinging/burning. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html © The Swiss Pharmacy

14. Canesten Cream (Generic Clotrimazole Cream) Possible Side Effects As with all medicines, some people may be allergic to Canesten Cream (Generic Clotrimazole Cream). If you or your baby are allergic, a reaction will occur soon after you start using it. If you or your baby experience an allergic reaction, stop using Canesten Cream and inform your doctor immediately or contact the accident and emergency department of your nearest hospital. Signs of an allergic reaction may include: Rash, Swallowing or breathing problems, Swelling of your lips, face, throat or tongue, Weakness, feeling dizzy or faint and Nausea. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html © The Swiss Pharmacy

15. Canesten Cream (Generic Clotrimazole Cream) Canesten Cream Overdosage Acute overdosage with topical application of Clotrimazole Cream is unlikely and would not be expected to lead to a life- threatening situation. There is no specific antidote. However, in the event of accidental oral ingestion, routine measures such as gastric lavage should be performed only if clinical symptoms of overdose become apparent (e.g. dizziness, nausea or vomiting). Gastric lavage should be carried out only if the airway can be protected adequately. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html © The Swiss Pharmacy

16. Canesten Cream (Generic Clotrimazole Cream) Canesten 1% Cream During Pregnancy Clotrimazole Cream (Canesten Cream) has been classified by the US FDA as Pregnancy Category B. Clotrimazole is very poorly absorbed following dermal application or intravaginal administration to humans. In clinical trials, use of vaginally applied Clotrimazole in pregnant women in their second and third trimesters has not been associated with ill effects. There are, however, no adequate and well-controlled studies in pregnant women during the first trimester of pregnancy. Studies in pregnant rats with intravaginal doses up to 100 mg/kg have revealed no evidence of harm to the fetus due to Clotrimazole. High oral doses of Clotrimazole in rats and mice ranging from 50 to 120 mg/kg resulted in embroyotoxicity, impairment of mating, decreased litter size and number of viable young and decreased pup survival to weaning. © The Swiss Pharmacy

17. Canesten Cream (Generic Clotrimazole Cream) Canesten 1% Cream During Pregnancy Because animal reproduction studies are not always predictive of human response, this medicine should be used only if clearly indicated during the first trimester of pregnancy. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html © The Swiss Pharmacy

18. Canesten Cream (Generic Clotrimazole Cream) Canesten 1% Cream Canesten 1% Cream (Generic Clotrimazole Cream) manufactured by Bayer Zydus Pharma Private Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9533_Clotrimazole-Cream.html © The Swiss Pharmacy