Flutivate Cream (Generic Fluticasone Propionate Cream)

1. Flutivate Cream (Generic Fluticasone Propionate Cream) © The Swiss Pharmacy

2. Flutivate Cream (Generic Fluticasone Propionate Cream) Flutivate cream (Generic Fluticasone Propionate Cream) is a topical (for the skin) steroid used to treat inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis. Flutivate is not used to treat rosacea, severe acne, or viral skin infections such as chickenpox or herpes. © The Swiss Pharmacy

3. Flutivate Cream (Generic Fluticasone Propionate Cream) Flutivate cream is manufactured by GlaxoSmithKline Pharmaceuticals Limited, India in the strength of 0.005%. © The Swiss Pharmacy

4. Flutivate Cream (Generic Fluticasone Propionate Cream) Chemical Structure © The Swiss Pharmacy

5. Flutivate Cream (Generic Fluticasone Propionate Cream) The active ingredient contained in Flutivate cream (Flutivate ointment) is Fluticasone Propionate. Flutivate cream contains Fluticasone Propionate 0.005% w/w. © The Swiss Pharmacy

6. Flutivate Cream (Generic Fluticasone Propionate Cream) Uses of Flutivate 0.005% Cream: Flutivate cream (Generic Fluticasone Propionate Cream) is a medium potency corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. It reduces swelling, redness, itching, and rashes caused by skin conditions, such as eczema. It works by decreasing inflammation of the skin. It belongs to a group of medications called topical steroids. Flutivate ointment may be used with caution in pediatric patients 3 months of age or older. The safety and efficacy of drug use for longer than 4 weeks in this population have not been established. The safety and efficacy of Flutivate Cream (Flutivate ointment) in pediatric patients below 3 months of age have not been established. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html © The Swiss Pharmacy

7. Flutivate Cream (Generic Fluticasone Propionate Cream) Recommended Adult Dosage The dose of Flutivate cream (Generic Fluticasone Cream) is given below: Apply thinly and gently rub into affected area once or twice a day for up to 4 weeks until improvement occurs, then reduce frequency or change to a less potent preparation. If the condition worsens or does not improve within 4 weeks, treatment and diagnosis should be re-evaluated. Gradually discontinue once controlled and use an emollient as maintenance therapy. Rebound of pre-existing dermatoses can occur with abrupt discontinuation. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html © The Swiss Pharmacy

8. Flutivate Cream (Generic Fluticasone Propionate Cream) Recommended Adult Dosage Adults and Elderly: Re-evaluate treatment and diagnosis if condition worsens or no improvement within 4 weeks. Children And Infants Aged 3 Months Of Age Or Older: Withdraw treatment and re-evaluate if no improvement within 7 to 14 days. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html © The Swiss Pharmacy

9. Flutivate Cream (Generic Fluticasone Propionate Cream) Contraindications ➔Flutivate cream is contraindicated in patients with a known hypersensitivity to Fluticasone Propionate or any component of the tablet. ➔The following conditions should not be treated with Fluticasone Propionate cream: untreated cutaneous infections, rosacea, acne vulgaris, perioral dermatitis, perianal and genital pruritus, pruritus without inflammation, dermatoses in infants under three months of age, including dermatitis and nappy rash. ➔Flutivate cream is not indicated for topical application to the eye. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html © The Swiss Pharmacy

10. Flutivate Cream (Generic Fluticasone Propionate Cream) Storage Instructions Flutivate Cream (Generic Fluticasone Propionate Cream) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html © The Swiss Pharmacy

11. Flutivate Cream (Generic Fluticasone Propionate Cream) Warnings Local skin irritation, local hypersensitivity, risk of hypercortisolism (Cushing's syndrome) and reversible hypothalamic-pituitary adrenal (HPA) axis suppression could occur. Avoid prolonged use where possible, especially in infants and children under 12 years of age as adrenal suppression is more likely to occur – treatment should be limited to 7 to 14 days. Prolonged application to the face is undesirable. If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye. Avoid occlusion due to risk of infection. May be associated with a higher occurrence of local hypersensitivity reactions and an increased risk of local infection around chronic leg ulcers. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html © The Swiss Pharmacy

12. Flutivate Cream (Generic Fluticasone Propionate Cream) Warnings Close supervision required if used in psoriasis as rebound relapses, development of tolerances, risk of generalized pustular psoriasis and development of local or systemic toxicity due to impaired barrier function of the skin have been reported in some cases. If used in psoriasis, careful patient supervision is important. Initiate antimicrobial therapy if lesions have become infected; any spread of infection requires withdrawal of topical corticosteroid therapy and administration of antimicrobial therapy. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html © The Swiss Pharmacy

13. Flutivate Cream (Generic Fluticasone Propionate Cream) Possible Side Effects In controlled clinical trials of twice-daily administration, the total incidence of side effects associated with the use of Fluticasone Propionate Cream (Flutivate cream) was approximately 4%. These side effects were usually mild; self-limiting; and consisted primarily of pruritus, dryness, numbness of fingers, and burning. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html © The Swiss Pharmacy

14. Flutivate Cream (Generic Fluticasone Propionate Cream) Possible Side Effects Two clinical studies compared once- to twice-daily administration of Fluticasone Propionate Cream (Flutivate cream) for the treatment of moderate to severe eczema. The local drug-related side effects for the patients enrolled in both studies are: Skin infection,Infected eczema, Viral warts,Herpes simplex, Impetigo, Atopic dermatitis, Eczema, Exacerbation of eczema, Erythema, Burning, Stinging, Skin irritation, Pruritus, Exacerbation of pruritus, Folliculitis, Blisters and Dryness of skin. Side effects from pediatric open-label trial include Burning, Dusky erythema, Erythematous rash, Facial telangiectasia, Non-facial telangiectasia and Urticaria. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html © The Swiss Pharmacy

15. Flutivate Cream (Generic Fluticasone Propionate Cream) Possible Side Effects The following local side effects have been reported infrequently with topical corticosteroids, and they may occur more frequently with the use of occlusive dressings and higher potency corticosteroids. These reactions are listed in an approximately decreasing order of occurrence: irritation, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae, hypertrichosis and miliaria. Also, there are reports of the development of pustular psoriasis from chronic plaque psoriasis following reduction or discontinuation of potent topical corticosteroid products. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html © The Swiss Pharmacy

16. Flutivate Cream (Generic Fluticasone Propionate Cream) Flutivate Cream Overdosage Topically applied Fluticasone Propionate Cream (Flutivate cream) can be absorbed in sufficient amounts to produce systemic effects. In case of chronic overdosage or misuse, the features of hypercorticism may appear. As with any corticosteroid, treatment should be discontinued if the symptoms of hypercorticism appear. It is important that the treatment is gradually withdrawn by reducing the frequency of application or by substituting a less potent corticosteroid because of the risk of glucocorticosteroid insufficiency. Further management should be as clinically indicated. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html © The Swiss Pharmacy

17. Flutivate Cream (Generic Fluticasone Propionate Cream) Flutivate Cream During Pregnancy Fluticasone Propionate Cream (Flutivate cream) has been classified by the US FDA as Pregnancy Category C. Corticosteroids have been shown to be teratogenic in laboratory animals when administered systemically at relatively low dosage levels. Some corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women. Flutivate cream should be used during pregnancy only if the expected benefit to the mother justifies the potential risk to the fetus. The minimum quantity should be used for the minimum duration. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html © The Swiss Pharmacy

18. Flutivate Cream (Generic Fluticasone Propionate Cream) Flutivate Cream Flutivate Cream (Generic Fluticasone Propionate Cream) is manufactured by GlaxoSmithKline Pharmaceuticals Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9702_Flutivate-Cream.html © The Swiss Pharmacy