Letromina Tablets (Generic Letrozole Tablets)

1. Letromina Tablets (Generic Letrozole Tablets) © The Swiss Pharmacy

2. Letromina Tablets (Generic Letrozole Tablets) Letromina (Generic Letrozole Tablets) is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Letromina is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Letrozole decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers. Letrozole has also been used off-label for more than 15 years to treat infertility in women with PCOS. © The Swiss Pharmacy

3. Letromina Tablets (Generic Letrozole Tablets) Letromina Tablets are manufactured by Alpha Pharma Healthcare Private limited, India in the strength of 2.5 mg. © The Swiss Pharmacy

4. Letromina Tablets (Generic Letrozole Tablets) Chemical Structure © The Swiss Pharmacy

5. Letromina Tablets (Generic Letrozole Tablets) The active ingredient contained in Letromina tablets is Letrozole. Each Letromina tablet contains 2.5 mg of Letrozole. © The Swiss Pharmacy

6. Letromina Tablets (Generic Letrozole Tablets) Uses of Letromina 2.5 mg Tablets: Letromina (Generic Letrozole Tablets) is used to treat certain types of breast cancer in women who have already stopped menstruating (postmenopausal). It is also used for women who have already had other cancer treatments (eg, Tamoxifen). Female hormones that occur naturally in the body can increase the growth of some breast cancers. Letrozole works by decreasing the amounts of these hormones in the body. Letromina (Letrozole) is also an effective fertility treatment for women with ovulation problems, or for those with unexplained infertility. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html © The Swiss Pharmacy

7. Letromina Tablets (Generic Letrozole Tablets) Recommended Adult Dosage The recommended dose of Letromina tablets Letrozole tablets) is 2.5 mg once daily. In patients with advanced or metastatic breast cancer, treatment with Letrozole tablets should continue until tumour progression is evident. Patients with cirrhosis or severe hepatic impairment: 2.5 mg every other day. In the adjuvant and extended adjuvant setting, treatment with Letrozole tablets should continue for 5 years or until tumour relapse occurs, whichever is first. Letromina tablets (Generic URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html © The Swiss Pharmacy

8. Letromina Tablets (Generic Letrozole Tablets) Recommended Adult Dosage – Fertility Treatment Letromina (Generic Letrozole Tablets) is an oral medication used to stimulate ovulation in women with polycystic ovary syndrome (PCOS) and unexplained infertility. Fertility treatment will be taken over five consecutive days. Some fertility experts recommend taking the pills on days 3, 4, 5, 6 and 7 of your cycle. Others endorse days 5, 6, 7, 8, and 9. Based on when treatment began, you can anticipate when you would need to start having sex: URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html © The Swiss Pharmacy

9. Letromina Tablets (Generic Letrozole Tablets) Recommended Adult Dosage – Fertility Treatment Based on when treatment began, you can anticipate when you would need to start having sex: If you started treatment on day 3, you likely ovulate sometime between day 14 and day 17 of your cycle. To conceive, you would want to begin having sex before you ovulate. In this scenario, you would begin having sex every day (or every other day) starting on day 11 and ending on day 18. If you started treatment on day 5, you would most likely ovulate between days 16 and 19. In this case, would start having sex between days 13 and 21. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html © The Swiss Pharmacy

10. Letromina Tablets (Generic Letrozole Tablets) Contraindications ➔Letromina is contraindicated in patients with a known hypersensitivity to Letrozole or any component of the tablet. ➔Administration of is contraindicated in Premenopausal endocrine status. ➔Premenopausal, pregnant or lactating women URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html © The Swiss Pharmacy

11. Letromina Tablets (Generic Letrozole Tablets) Storage Instructions Letromina Tablets (Generic Letrozole Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html © The Swiss Pharmacy

12. Letromina Tablets (Generic Letrozole Tablets) Warnings Use of Letrozole (Letromina tablets) may cause decreases in Bone Mineral Density (BMD). Consideration should be given to monitoring BMD. Consideration should be given to monitoring serum cholesterol. In the adjuvant trial (BIG 1-98), hypercholesterolemia was reported in 52.3% of letrozole patients and 28.6% of Tamoxifen patients. Grade 3 to 4 hypercholesterolemia was reported in 0.4% of Letrozole (Letromina tablets) patients and 0.1% of Tamoxifen patients. Subjects with cirrhosis and severe hepatic impairment who were dosed with 2.5 mg of Letrozole tablets experienced approximately twice the exposure to Letrozole as healthy volunteers with normal liver function. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html © The Swiss Pharmacy

13. Letromina Tablets (Generic Letrozole Tablets) Warnings Because fatigue, dizziness, and somnolence have been reported with the use of letrozole, caution is advised when driving or using machinery until it is known how the patient reacts to Letrozole use. No dose-related effect of Letrozole (Letromina tablets) on any hematologic or clinical chemistry parameter was evident. Moderate decreases in lymphocyte counts, of uncertain clinical significance, were observed in some patients receiving Letrozole 2.5 mg. This depression was transient in about half of those affected. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html © The Swiss Pharmacy

14. Letromina Tablets (Generic Letrozole Tablets) Warnings Based on postmarketing reports, findings from animal studies and the mechanism of action, Letrozole (Letromina tablets) can cause fetal harm and is contraindicated for use in pregnant women. In postmarketing reports, use of Letrozole during pregnancy resulted in cases of spontaneous abortions and congenital birth defects. Letrozole caused embryo-fetal toxicities in rats and rabbits at maternal exposures that were below the maximum recommended human dose (MHRD) on a mg/m2 basis. Advise pregnant women of the potential risk to a fetus. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html © The Swiss Pharmacy

15. Letromina Tablets (Generic Letrozole Tablets) Possible Side Effects The most serious side effects from the use of Letrozole (Letromina tablets) are Bone effects and increases in cholesterol. The most frequently reported side effects in the clinical studies were hot flushes, arthralgia, nausea and fatigue. Many side effects can be attributed to the normal pharmacological consequences of oestrogen deprivation (e.g., hot flushes, alopecia and vaginal bleeding). URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html © The Swiss Pharmacy

16. Letromina Tablets (Generic Letrozole Tablets) Overdosage Isolated cases of Letrozole (Letromina tablets) overdose have been reported. In these instances, the highest single dose ingested was 62.5 mg or 25 tablets. While no serious adverse reactions were reported in these cases, because of the limited data available, no firm recommendations for treatment can be made. However, emesis could be induced if the patient is alert. In general, supportive care and frequent monitoring of vital signs are also appropriate. In single-dose studies, the highest dose used was 30 mg, which was well tolerated; in multiple-dose trials, the largest dose of 10 mg was well tolerated. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html © The Swiss Pharmacy

17. Letromina Tablets (Generic Letrozole Tablets) Letromina Tablets During Pregnancy Letrozole (Letromina tablets) has been classified by the US FDA as Pregnancy Category X. Letrozole (Letromina tablets) is contraindicated in women who are or may become pregnant. Letrozole may cause foetal harm when administered to a pregnant woman and the clinical benefit to premenopausal women with breast cancer has not been demonstrated. If this medication is used during pregnancy or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the foetus. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html © The Swiss Pharmacy

18. Letromina Tablets (Generic Letrozole Tablets) Letromina Tablets During Pregnancy Animal data and Letrozole’s mechanism of action raise concerns that Letrozole (Letromina tablets) could be a human teratogen as well. Physicians should discuss the need for adequate contraception with women patients who are recently menopausal. Contraception should be used until postmenopausal status is clinically well established. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html © The Swiss Pharmacy

19. Letromina Tablets (Generic Letrozole Tablets) Letromina Tablets Letromina Tablets (Generic Letrozole Tablets) are manufactured by Alpha Pharma Healthcare Private limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9804_Letrozole-Tablets.html © The Swiss Pharmacy