Rpigat Tablets (Generic Rivaroxaban Tablets)

1. Rpigat Tablets (Generic Rivaroxaban Tablets) © The Swiss Pharmacy

2. Rpigat Tablets (Generic Rivaroxaban Tablets) Rpigat Tablets (Generic Rivaroxaban Tablets) are used for reduction of Risk of Stroke and Systemic Embolism in valvular Atrial Fibrillation, Treatment of Deep Vein Thrombosis, Treatment of Pulmonary Embolism; Reduction in the Risk of Recurrence of Deep Vein Thrombosis and/or Pulmonary Embolism; Prophylaxis of Deep Vein Thrombosis Following Hip or Knee Replacement Surgery; Reduction of Risk of Major Cardiovascular Events in Patients with Chronic Coronary Artery Disease (CAD) or Peripheral Artery Disease (PAD). © The Swiss Pharmacy

3. Rpigat Tablets (Generic Rivaroxaban Tablets) Rpigat Tablets are manufactured by NATCO Pharma Limited, India in the strengths of 10 mg, 15 mg and 20 mg. © The Swiss Pharmacy

4. Rpigat Tablets (Generic Rivaroxaban Tablets) Chemical Structure © The Swiss Pharmacy

5. Rpigat Tablets (Generic Rivaroxaban Tablets) The active ingredient contained in Rpigat tablets is Rivaroxaban. Each film-coated Rpigat tablet contains 10 mg, 15 mg or 20 mg of Rivaroxaban. © The Swiss Pharmacy

6. Rpigat Tablets (Generic Rivaroxaban Tablets) Uses of Rpigat 10 mg, 15 mg and 20 mg tablets: Rpigat tablets (Generic Rivaroxaban tablets) manufactured by NATCO Pharma Limited, India are used to treat and prevent deep venous thrombosis (DVT), a condition in which harmful blood clots form in the blood vessels of the legs. These blood clots can travel to the lungs and can become lodged in the blood vessels of the lungs, causing a condition called pulmonary embolism (PE). This medicine is used for several days after hip or knee replacement surgery while you are unable to walk. Rivaroxaban tablets are also used to prevent stroke and blood clots in patients with certain heart rhythm problems (eg, nonvalvular atrial fibrillation). It is also used together with aspirin to decrease the risk of serious heart problems, heart attack, and stroke in patients with coronary artery disease (a condition where the blood supply to the heart is reduced or blocked). URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html © The Swiss Pharmacy

7. Rpigat Tablets (Generic Rivaroxaban Tablets) Uses of Rpigat 10 mg, 15 mg and 20 mg tablets: This medicine is also used together with aspirin to lower the risk of sudden decrease in blood flow to the legs, major amputation, heart attack, or stroke in patients with peripheral artery disease (a condition where the blood flow to the legs is reduced), including patients who have had a recent surgery to improve blood flow to the legs. Rivaroxaban is a factor Xa inhibitor, an anticoagulant. It works by decreasing the clotting ability of the blood and helps prevent harmful clots from forming in the blood vessels. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html © The Swiss Pharmacy

8. Rpigat Tablets (Generic Rivaroxaban Tablets) Recommended Adult Dosage The dosage of Rpigat tablets Rpigat tablets (Generic Rivaroxaban tablets) for the various indications is given below: Nonvalvular Atrial Fibrillation: For patients with Creatinine clearance (CrCl) greater than 50 mL/min: 20 mg orally, once daily with the evening meal For patients with CrCl 15 to 50 mL/min: 15 mg orally, once daily with the evening meal. Avoid use in patients with CrCl less than 15 mL/min. Prophylaxis of Deep Vein Thrombosis (DVT): 10 mg orally, once daily with or without food. Hepatic impairment (for nonvalvular AF and prophylaxis of DVT indications): Avoid use in patients with moderate (Child-Pugh B) and severe (Child-Pugh C) hepatic impairment or with any degree of hepatic disease associated with coagulopathy. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html © The Swiss Pharmacy

9. Rpigat Tablets (Generic Rivaroxaban Tablets) Contraindications ➔Rpigat is contraindicated in patients with a known hypersensitivity (e.g., anaphylactic reactions) to Rivaroxaban or any component of the tablet. ➔Administration of Rpigat tablets is contraindicated in patients with active pathological bleeding. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html © The Swiss Pharmacy

10. Rpigat Tablets (Generic Rivaroxaban Tablets) Storage Instructions Rivaroxaban tablets (Rpigat tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html © The Swiss Pharmacy

11. Rpigat Tablets (Generic Rivaroxaban Tablets) Warnings Risk of bleeding: Rivaroxaban tablets (Rpigat tablets) can cause serious and fatal bleeding. An agent to reverse the activity of Rivaroxaban is available. Pregnancy-related hemorrhage: Use Rivaroxaban tablets (Rpigat tablets) with caution in pregnant women due to the potential for obstetric hemorrhage and/or emergent delivery. Prosthetic heart valves: Rivaroxaban tablets (Rpigat tablets) use not recommended. Increased Risk of Thrombosis in Patients with Triple Positive Antiphospholipid Syndrome: Rivaroxaban tablets (Rpigat tablets) use not recommended. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html © The Swiss Pharmacy

12. Rpigat Tablets (Generic Rivaroxaban Tablets) Possible Side Effects The most common Rivaroxaban (Rpigat tablets) side effect with an incidence rate of 5% or more in adult patients was bleeding. The most common Rivaroxaban (Rpigat tablets) side effects with an incidence rate of 10% or greater in pediatric patients were bleeding, cough, vomiting, and gastroenteritis. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html © The Swiss Pharmacy

13. Rpigat Tablets (Generic Rivaroxaban Tablets) Overdosage Overdose of Rivaroxaban (Rpigat tablets) may lead to hemorrhage. Discontinue Rpigat tablets and initiate appropriate therapy if bleeding complications associated with overdosage occur. Rivaroxaban systemic exposure is not further increased at single doses more than 50 mg due to limited absorption. The use of activated charcoal to reduce absorption in case of Rivaroxaban overdose may be considered. Due to the high plasma protein binding, Rivaroxaban is not dialyzable. Partial reversal of laboratory anticoagulation parameters may be achieved with use of plasma products. An agent to reverse the anti- factor Xa activity of Rivaroxaban is available. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html © The Swiss Pharmacy

14. Rpigat Tablets (Generic Rivaroxaban Tablets) Rpigat Tablets During Pregnancy Rivaroxaban (Rpigat tablets) has been classified by the US FDA as Pregnancy Category C. There are no adequate or well-controlled studies of Rivaroxaban tablets in pregnant women. Safety and efficacy of Rivaroxaban tablets have not been established in pregnant women. Studies in animals have shown reproductive toxicity. Due to the potential reproductive toxicity, the intrinsic risk of bleeding and the evidence that Rivaroxaban passes the placenta, Rivaroxaban (Rpigat tablets) is contraindicated during pregnancy. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html © The Swiss Pharmacy

15. Rpigat Tablets (Generic Rivaroxaban Tablets) Rpigat Tablets During Pregnancy Women of child-bearing potential should avoid becoming pregnant during treatment with Rivaroxaban. The anticoagulant effect of Rivaroxaban (Rpigat tablets) cannot be reliably monitored with standard laboratory testing. Doctors should consider the benefits and risks of Rpigat tablets for the mother and possible risks to the fetus when prescribing Rivaroxaban tablets to a pregnant woman. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html © The Swiss Pharmacy

16. Rpigat Tablets (Generic Rivaroxaban Tablets) Rpigat Tablets are manufactured by NATCO Pharma Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9968_Generic-Rivaroxaban-Tablets.html © The Swiss Pharmacy