Silagra Tablets (Generic Sildenafil Citrate Tablets)

1. Silagra Tablets (Generic Sildenafil Citrate Tablets) © The Swiss Pharmacy

2. Silagra Tablets (Generic Sildenafil Citrate Tablets) Silagra (Generic Sildenafil Citrate Tablets) is a treatment for adult men with erectile dysfunction, sometimes known as impotence, also known in short as ED. This is when a man cannot get, or keep a hard, erect penis suitable for sexual activity. In combination with sexual stimulation, Sildenafil works by increasing blood flow to the penis to help a man get and keep an erection. Silagra tablets are available in strengths of 100 mg. © The Swiss Pharmacy

3. Silagra Tablets (Generic Sildenafil Citrate Tablets) Silagra tablets are manufactured by Cipla Limited, India in strengths of 50 mg and 100 mg. © The Swiss Pharmacy

4. Silagra Tablets (Generic Sildenafil Citrate Tablets) Chemical Structure © The Swiss Pharmacy

5. Silagra Tablets (Generic Sildenafil Citrate Tablets) The active ingredient contained in Silagra tablets is Sildenafil Citrate. Each film-coated Silagra tablet contains Sildenafil Citrate equivalent to 50 mg or 100 mg of Sildenafil. © The Swiss Pharmacy

6. Silagra Tablets (Generic Sildenafil Citrate Tablets) Uses of Silagra 50 mg and 100 mg Tablets: Silagra (Generic Sildenafil Citrate Tablets) is an oral treatment for adult men suffering from erectile dysfunction. Sildenafil Citrate belongs to a group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors. Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. When a man is sexually stimulated, his body's normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, sildenafil helps to maintain an erection after the penis is stroked. Without physical action to the penis, such as that occurring during sexual intercourse, Sildenafil will not work to cause an erection. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy

7. Silagra Tablets (Generic Sildenafil Citrate Tablets) Uses of Silagra 50 mg and 100 mg Tablets: Silagra Tablets (Generic Sildenafil Citrate 100 mg tablets) for erectile dysfunction can be taken by men aged 18 and over. It's not for women or children. Sildenafil is also used in both men and women to treat the symptoms of pulmonary arterial hypertension. This is a type of high blood pressure that occurs between the heart and the lungs. Sildenafil works on the PDE5 enzyme in the lungs to relax the blood vessels. This will increase the supply of blood to the lungs and reduce the workload of the heart. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy

8. Silagra Tablets (Generic Sildenafil Citrate Tablets) Recommended Adult Dosage For most patients, the recommended dose of Silagra Tablets (Generic Sildenafil Tablets) is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, Silagra (Generic Sildenafil Citrate tablets) may be taken anywhere from 30 minutes to 4 hours before sexual activity. Based on effectiveness and toleration, the dosage may be increased to a maximum of 100 mg or decreased to 25 mg. Maximum recommended dosing frequency is once per day (i.e. 24 hours must pass before you take the next dose) Silagra Tablets URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy

9. Silagra Tablets (Generic Sildenafil Citrate Tablets) Recommended Adult Dosage Use in the Elderly: Use in the Elderly: Since Sildenafil clearance is reduced in elderly patients, a first dose of 25 mg should be considered. Based on efficacy and tolerance, the dose may be increased to 50 and 100 mg. Impaired Renal Function: Impaired Renal Function: The dosing recommendations for adults should be followed for patients with mild to moderate renal impairment (creatinine clearance equals 30 to 80 mL/minute). Since Sildenafil clearance is reduced in patients with severe renal impairment (creatinine clearance less than 30 mL/minute) a 25 mg starting dose should be considered. Based on efficacy and tolerance, the dose may be increased to 50 and 100 mg. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy

10. Silagra Tablets (Generic Sildenafil Citrate Tablets) Recommended Adult Dosage Impaired Hepatic Function: Impaired Hepatic Function: Since Sildenafil clearance is reduced in patients with hepatic impairment (e.g. cirrhosis) a 25 mg starting dose should be considered. Based on efficacy and tolerance, the dose may be increased to 50 and 100 mg URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy

11. Silagra Tablets (Generic Sildenafil Citrate Tablets) Contraindications ➔Silagra is contraindicated in patients with a known hypersensitivity to Sildenafil Citrate or any component of the tablet. ➔Administration of Silagra to patients using nitric oxide donors, such as organic nitrates or organic nitrites in any form. Silagra was shown to potentiate the hypotensive effect of nitrates. ➔Administration of Silagra with Guanylate Cyclase (GC) stimulators, such as Riociguat is contraindicated. ➔Silagra tablets (Sildenafil) is contraindicated in men for whom sexual intercourse is inadvisable due to cardiovascular risk factors (e.g. patients with severe cardiovascular disease such as established cardiac failure and unstable angina pectoris) URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy

12. Silagra Tablets (Generic Sildenafil Citrate Tablets) Storage Instructions Silagra Tablets (Generic Sildenafil Citrate Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy

13. Silagra Tablets (Generic Sildenafil Citrate Tablets) Warnings Patients should not use Silagra if sexual activity is inadvisable due to cardiovascular status. Patients should seek emergency treatment if an erection lasts for greater than 4 hours. Use Silagra with caution in patients predisposed to priapism. Patients should stop Silagra and seek medical care if a sudden loss of vision occurs in one or both eyes, which could be a sign of non arteritic anterior ischemic optic neuropathy (NAION). Silagra should be used with caution, and only when the anticipated benefits outweigh the risks, in patients with a history of NAION. Patients with a "crowded" optic disc may also be at an increased risk of NAION. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy

14. Silagra Tablets (Generic Sildenafil Citrate Tablets) Warnings Patients should stop Silagra and seek prompt medical attention in the event of sudden decrease or loss of hearing. Caution is advised when Silagra is co-administered with alpha-blockers or anti-hypertensives. Concomitant use may lead to hypotension. Decreased blood pressure, syncope, and prolonged erection may occur at higher Sildenafil exposures. In patients taking strong CYP inhibitors, such as Ritonavir, Sildenafil exposure is increased. Decrease in Silagra dosage is recommended. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy

15. Silagra Tablets (Generic Sildenafil Citrate Tablets) Silagra Tablets and Driving Sildenafil Citrate (Silagra tablets) does not make you sleepy and so it's usually safe to drive or ride a bike while taking this medicine. However, do not drive, cycle or operate machinery if it makes you feel dizzy or affects your eyesight. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy

16. Silagra Tablets (Generic Sildenafil Citrate Tablets) Possible Side Effects Most common Silagra (Generic Sildenafil Citrate tablets) side effects with an incidence rate of greater than or equal to 2% include headache, flushing, dyspepsia, abnormal vision, nasal congestion, back pain, myalgia, nausea, dizziness and rash. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy

17. Silagra Tablets (Generic Sildenafil Citrate Tablets) Possible Side Effects The following side effects occurred in less than 2% of of patients in controlled clinical trials; a causal relationship to Sildenafil Citrate (Silagra Tablets) is uncertain. Body as a Whole: face edema, photosensitivity reaction, shock, asthenia, pain, chills, accidental fall, abdominal pain, allergic reaction, chest pain, accidental injury. Cardiovascular: angina pectoris, AV block, migraine, syncope, tachycardia, palpitation, hypotension, postural hypotension, myocardial ischemia, cerebral thrombosis, cardiac arrest, heart failure, abnormal electrocardiogram, cardiomyopathy. Digestive: vomiting, glossitis, colitis, dysphagia, gastritis, gastroenteritis, esophagitis, stomatitis, dry mouth, liver function tests abnormal, rectal hemorrhage, gingivitis. Hemic and Lymphatic: anemia and leukopenia. Metabolic and Nutritional: thirst, edema, gout, unstable diabetes, hyperglycemia, peripheral edema, hyperuricemia, hypoglycemic reaction, hypernatremia. Musculoskeletal: arthritis, arthrosis, myalgia, tendon rupture, tenosynovitis, bone pain, myasthenia, synovitis. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy

18. Silagra Tablets (Generic Sildenafil Citrate Tablets) Possible Side Effects The following side effects occurred in less than 2% of of patients in controlled clinical trials; a causal relationship to Sildenafil Citrate (Silagra Tablets) is uncertain. Nervous: ataxia, hypertonia, neuralgia, neuropathy, paresthesia, tremor, vertigo, depression, insomnia, somnolence, abnormal dreams, reflexes decreased, hypesthesia. Respiratory: asthma, dyspnea, laryngitis, pharyngitis, sinusitis, bronchitis, sputum increased, cough increased. Skin and Appendages: urticaria, herpes simplex, pruritus, sweating, skin ulcer, contact dermatitis, exfoliative dermatitis. Special Senses: sudden decrease or loss of hearing, mydriasis, conjunctivitis, photophobia, tinnitus, eye pain, ear pain, eye hemorrhage, cataract, dry eyes. Urogenital: cystitis, nocturia, urinary frequency, breast enlargement, urinary incontinence, abnormal ejaculation, genital edema and anorgasmia. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy

19. Silagra Tablets (Generic Sildenafil Citrate Tablets) Silagra Tablets Overdosage Overdose information of Sildenafil Citrate (Silagra Tablets) is limited. In studies with healthy volunteers, of single doses up to 800mg, adverse effects were similar to those seen at lower doses but incidence rates and severities were increased. Survival is reported in a 42-year-old female following an overdose with 2,000mg Sildenafil. In cases of overdose, standard supportive measures should be adopted as required. Sildenafil blood levels are not clinically useful. Monitor ECG and blood pressure in symptomatic patients. Renal dialysis is not expected to accelerate clearance as Sildenafil is highly bound to plasma protein and not eliminated in the urine. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy

20. Silagra Tablets (Generic Sildenafil Citrate Tablets) Silagra Tablets During Pregnancy Sildenafil Citrate (Silagra Tablets) has been classified by the US FDA as Pregnancy Category B. Sildenafil is not indicated for use in females. There are no data with the use of Sildenafil in pregnant women to inform any drug-associated risks for adverse developmental outcomes. Animal reproduction studies conducted with Sildenafil did not show adverse developmental outcomes when administered during organogenesis in rats and rabbits at oral doses up to 16 and 32 times, respectively, the maximum recommended human dose (MRHD) of 100mg/day on a mg/m basis. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy

21. Silagra Tablets (Generic Sildenafil Citrate Tablets) Silagra Tablets Silagra Tablets (Generic Sildenafil Citrate Tablets) are manufactured by Cipla Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9603_Silagra-Tablets.html © The Swiss Pharmacy