Thyro3 Tablets (Generic Liothyronine Sodium Tablets)

1. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) © The Swiss Pharmacy

2. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Generic Liothyronine Sodium (Thyro3 Tablets) are used for the treatment of coma of myxedema, and treatment of some of the more severe conditions in which the thyroid does not produce enough thyroxine. It is also used to balance the effect of medicines used to treat an overactive thyroid. © The Swiss Pharmacy

3. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Thyro3 Tablets are manufactured by Alpha Pharma Healthcare Private limited, India in the strengths of 25 mcg. © The Swiss Pharmacy

4. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Chemical Structure © The Swiss Pharmacy

5. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) The active pharmaceutical ingredient contained in Thyro3 tablets is Liothyronine Sodium. Each Thyro3 tablet contains 25 mcg of Liothyronine Sodium. © The Swiss Pharmacy

6. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Uses of Thyro3 25 mcg tablets: Thyro3 Tablets (Generic Liothyronine Sodium Tablets) are used to treat hypothyroidism, a condition wherein the thyroid gland does not produce enough thyroid hormone. It is also used to help decrease the size of enlarged thyroid glands (goiter) and treat thyroid cancer. Liothyronine is also used in some medical tests to help diagnose problems with the thyroid gland. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html © The Swiss Pharmacy

7. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Recommended Adult Dosage The recommended dosage of Thyro3 Tablets given below: Adult Dosage for Mild Hypothyroidism:The initial dose is 25 mcg orally once a day; may be increased by up to 25 mcg every 1 or 2 weeks and the maintenance dose is 25 to 75 mcg/day. Adult Dosage for Congenital Hypothyroidism: The initial dose is 5 mcg orally once a day; increase in 5 mcg per day increments every 3 to 4 days until desired response is achieved. Usual Adult Dose for Myxedema: The initial dose is 5 mcg orally once a day. The dose may be increased by 5 to 10 mcg per day every 1 or 2 weeks; when 25 mcg/day is reached, dose may be increased by 5 to 25 mcg every 1 to 2 weeks until satisfactory response is attainted. The maintenance dose is 50 to 100 mcg/day. Usual Adult Dose for Thyroid Suppression Test: 75 to 100 mcg orally per day for 7 days. Thyro3 Tablets (Liothyronine Sodium) is URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html © The Swiss Pharmacy

8. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Recommended Adult Dosage The recommended dosage of Thyro3 Tablets Thyro3 Tablets (Liothyronine Sodium) is given below: Usual Adult Dose for Goiter: Initial dose: 5 mcg orally once a day. Following initial dose the dose has to be increased by 5 to 10 mcg per day every 1 or 2 weeks; when 25 mcg/day is reached, dose may be increased by 12.5 or 25 mcg per day every 1 to 2 weeks until satisfactory response is attainted. The maintenance dose is 75 mcg orally once a day. Usual Geriatric Dose for Hypothyroidism: Start at 5 mcg orally once a day and increase by no more than 5 mcg increments at 2 week intervals. Usual Adult Dose for TSH Suppression: The initial dose is 5 mcg orally once a day. Following initial dose: Increase by 5 to 10 mcg per day every 1 or 2 weeks; when 25 mcg/day is reached, dose may be increased by 12.5 or 25 mcg per day every 1 to 2 weeks until satisfactory response is attainted. The maintenance dose is 75 mcg orally once a day. © The Swiss Pharmacy

9. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Recommended Adult Dosage The recommended dosage of Thyro3 Tablets given below: Usual Pediatric Dose for Congenital Hypothyroidism: Initial dose is 5 mcg orally once a day. Increase dosage in 5 mcg per day increments every 3 to 4 days until desired response is achieved.The Maintenance dose is as follows: Infants a few months old may require only 20 mcg/day for while patients at 1 year may require 50 mcg/day; above 3 years, the full adult dosage may be necessary. Thyro3 Tablets (Liothyronine Sodium) is URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html © The Swiss Pharmacy

10. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Contraindications ➔Thyro3 tablets are contraindicated in patients with a known hypersensitivity to Liothyronine Sodium or any component of the tablet. ➔Thyro3 tablets are contraindicated in patients with uncorrected adrenal cortical insufficiency. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html © The Swiss Pharmacy

11. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Storage Instructions Thyro3 Tablets (Generic Liothyronine Sodium Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html © The Swiss Pharmacy

12. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Warnings Cardiac adverse reactions in the elderly and in patients with underlying cardiovascular disease: Initiate Thyro3 tablets (Liothyronine Sodium) at less than the full replacement dose because of the increased risk of cardiac adverse reactions, including atrial fibrillation. Myxedema coma: Do not use oral thyroid hormone drug products to treat myxedema coma. Acute adrenal crisis in patients with concomitant adrenal insufficiency: Treat with replacement glucocorticoids prior to initiation of Thyro3 tablets treatment. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html © The Swiss Pharmacy

13. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Warnings Prevention of hyperthyroidism or incomplete treatment of hypothyroidism: Proper dose titration and careful monitoring is critical to prevent the persistence of hypothyroidism or the development of hyperthyroidism. Worsening of diabetic control: Therapy in patients with diabetes mellitus may worsen glycemic control and result in increased antidiabetic agent or insulin requirements. Carefully monitor glycemic control after starting, changing, or discontinuing thyroid hormone therapy. Decreased bone mineral density associated with thyroid hormone over-replacement: Over-replacement can increase bone resorption and decrease bone mineral density. Give the lowest effective dose. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html © The Swiss Pharmacy

14. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Possible Side Effects Side effects associated with Liothyronine Sodium (Thyro3 tablets) therapy are primarily those of hyperthyroidism due to therapeutic overdosage. They include the following: General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia Musculoskeletal: tremors, muscle weakness and cramps Cardiovascular: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html © The Swiss Pharmacy

15. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Possible Side Effects Side effects associated with Liothyronine Sodium (Thyro3 tablets) therapy are primarily those of hyperthyroidism due to therapeutic overdosage. They include the following: Respiratory: dyspnea Gastrointestinal: diarrhea, vomiting, abdominal cramps, elevations in liver function tests Dermatologic: hair loss, flushing Endocrine: decreased bone mineral density Reproductive: menstrual irregularities, impaired fertility URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html © The Swiss Pharmacy

16. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Overdosage Signs And Symptoms: Headache, irritability, nervousness, sweating, arrhythmia (including tachycardia), increased bowel motility and menstrual irregularities. Angina pectoris or congestive heart failure may be induced or aggravated. Shock may also develop. Massive overdosage may result in symptoms resembling thyroid storm. Chronic excessive dosage will produce the signs and symptoms of hyperthyroidism. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html © The Swiss Pharmacy

17. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Overdosage Dosage should be reduced or therapy temporarily discontinued if signs and symptoms of overdosage appear. Treatment may be reinstituted at a lower dosage. In normal individuals, normal hypothalamicpituitary- thyroidaxis function is restored in 6 to 8 weeks after thyroid suppression. Treatment of acute massive thyroid hormone overdosage is aimed at reducing gastrointestinal absorption of the drugs and counteracting central and peripheral effects, mainly those of increased sympathetic activity. Vomiting may be induced initially if further gastrointestinal absorption can reasonably be prevented and barring contraindications such as coma, convulsions, or loss of the gagging reflex. Treatment is symptomatic and supportive. Oxygen may be administered and ventilation maintained. Cardiac glycosides may be indicated if congestive heart failure develops. Measures to control fever, hypoglycemia, or fluid loss should be instituted if needed. Antiadrenergic agents, particularly propranolol, have been used advantageously in the treatment of increased sympathetic activity. Propranolol may be administered intravenously at a dosage of 1 to 3 mg over a 10-minute period or orally, 80 to 160 mg/day, especially when no contraindications exist for its use. © The Swiss Pharmacy

18. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Thyro3 Tablets During Pregnancy Liothyronine Sodium (Thyro3 tablets) has been classified by the US FDA as Pregnancy Category A. Thyroid hormones do not readily cross the placental barrier. The clinical experience to date does not indicate any adverse effect on fetuses when thyroid hormones are administered to pregnant women. On the basis of current knowledge, thyroid replacement therapy to hypothyroid women should not be discontinued during pregnancy. Experience with L iothyronine use in pregnant women, including data from post-marketing studies, have not reported increased rates of major birth defects or miscarriages. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html © The Swiss Pharmacy

19. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Thyro3 Tablets During Pregnancy Liothyronine Sodium (Thyro3 tablets) has been classified by the US FDA as Pregnancy Category A. There are risks to the mother and fetus associated with untreated hypothyroidism in pregnancy. Since TSH levels may increase during pregnancy, TSH should be monitored and liothyronine sodium dosage adjusted during pregnancy (see Clinical Considerations). There are no animal studies conducted with liothyronine during pregnancy. Liothyronine Sodium tablets, USP should not be discontinued during pregnancy and hypothyroidism diagnosed during pregnancy should be promptly treated. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html © The Swiss Pharmacy

20. Thyro3 25 mcg Tablets (Generic Liothyronine Sodium Tablets) Thyro3 Tablets Thyro3 Tablets (Generic Liothyronine Sodium Tablets) are manufactured by Alpha Pharma Healthcare Private limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9946_Liothyronine-Sodium-Tablets.html © The Swiss Pharmacy