Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly)

1. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) © The Swiss Pharmacy

2. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Valif Oral Jelly (Generic Vardenafil Hydrochloride Jelly) is used for the treatment of erectile dysfunction in adult men. Erectile dysfunction is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. Valif Oral Jelly starts working about 15 minutes after consumption and the medical effect will last for 3 to 4 hours. In addition, the jelly sachets are more convenient to use than the traditional tablets. Each 5 gram sachet of Valif Oral Jelly contains 20 mg of the active ingredient Vardenafil. © The Swiss Pharmacy

3. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Valif Oral Jelly is manufactured by Ajanta Pharma Limited, India. Each 5 gram sachet of Valif Oral Jelly contains 20 mg of the active ingredient Vardenafil. © The Swiss Pharmacy

4. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Chemical Structure © The Swiss Pharmacy

5. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) The active ingredient contained in Valif Oral Jelly is Vardenafil Hydrochloride Trihydrate. Each 5 grams sachet of Valif Oral Jelly contains Vardenafil Hydrochloride Trihydrate equivalent to 20 mg of Vardenafil. © The Swiss Pharmacy

6. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Uses of Valif 20 mg Oral Jelly: Valif Oral Jelly (Generic Vardenafil Hydrochloride 20 mg Jelly) is a treatment for adult men suffering from male sexual function problems (impotence or erectile dysfunction-ED). Erectile dysfunction is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. When a man is sexually stimulated, his body's normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, Valif Oral Jelly helps to maintain an erection after the penis is stroked by increasing blood flow to the penis. Without physical action to the penis, such as that occurring during sexual intercourse, Valif Oral Jelly will not work to cause an erection. In combination with sexual stimulation, Vardenafil (Valif Oral Jelly) works by increasing blood flow to the penis to help a man get and keep an erection. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html © The Swiss Pharmacy

7. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Recommended Adult Dosage The dose of Valif Oral Jelly Valif Oral Jelly (Generic Vardenafil Hydrochloride Jelly) is one sachet of Valif Oral Jelly 20 mg taken taken as needed approximately 15 minutes before sexual activity. Generic Vardenafil Hydrochloride 20 mg Jelly may be taken with or without meals. Do not take Valif Oral Jelly more than once a day. i.e. At least 24 hours must pass before you take your next dose. In order for Vardenafil Jelly to be effective, sexual stimulation is required. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html © The Swiss Pharmacy

8. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Contraindications ➔Valif Oral Jelly is contraindicated in patients with a known hypersensitivity to Vardenafil Hydrochloride or any component of the tablet. ➔Administration with nitrates and nitric oxide donors is contraindicated. ➔Administration with Guanylate Cyclase (GC) stimulators, such as Riociguat is contraindicated. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html © The Swiss Pharmacy

9. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Storage Instructions Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html © The Swiss Pharmacy

10. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Warnings Cardiovascular Effects: Patients should not use Valif Oral Jelly if sex is inadvisable due to cardiovascular status. Risk of Priapism: In the event that an erection lasts more than 4 hours, the patient should seek immediate medical assistance. Effects on the Eye: Patients should stop use of Valif Oral Jelly, and seek medical attention in the event of sudden loss of vision in one or both eyes, which could be a sign of nonarteritic anterior ischemic optic neuropathy (NAION). Valif Oral Jelly should be used with caution, and only when the anticipated benefits outweigh the risks, in patients with a history of NAION. Patients with a “crowded” optic disc may also be at an increased risk of NAION. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html © The Swiss Pharmacy

11. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Warnings Sudden Hearing Loss: Patients should stop Valif Oral Jelly and seek medical attention in the event of sudden decrease or loss in hearing. Alpha-Blockers: Caution is advised when PDE5 inhibitors are coadministered with alpha-blockers. In some patients, concomitant use of these two drug classes can lower blood pressure significantly leading to symptomatic hypotension (for example, fainting). QT Prolongation: Patients with congenital QT syndrome or taking class IA or III antiarrhythmics should avoid using Valif Oral Jelly (Generic Vardenafil Hydrochloride Jelly). URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html © The Swiss Pharmacy

12. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Effects on Ability to Drive And Use Machines No studies on the effects on the ability to drive and use machines have been performed. As dizziness and abnormal vision have been reported in clinical trials with Vardenafil Hydrochloride tablets, patients should be aware of how they react to Valif Oral Jelly (Generic Vardenafil Hydrochloride Jelly), before driving or operating machines. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html © The Swiss Pharmacy

13. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Possible Side Effects Most common Vardenafil Hydrochloride (Valif Oral Jelly) side effects with an incidence rate of greater than or equal to 2% are headache, flushing, nasal congestion, dyspepsia, sinusitis, flu syndrome, dizziness, increased creatine kinase, nausea, back pain. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html © The Swiss Pharmacy

14. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Possible Side Effects The following are the serious side effects associated with the use of Vardenafil: Cardiovascular Effects, Priapism, Effects on Eye, Sudden Hearing Loss and QT Prolongation. Additional, less frequent side effects(less than 2%) reported during the clinical development of Vardenafil Hydrochloride film-coated tablets and Vardenafil orally disintegrating tablets include: Body as a whole: allergic edema and angioedema, feeling unwell, allergic reactions, chest pain Auditory: tinnitus, vertigo Cardiovascular: palpitation, tachycardia, angina pectoris, myocardial infarction, ventricular tachyarrhythmias, hypotension Digestive: nausea, gastrointestinal and abdominal pain, dry mouth, diarrhea, gastroesophageal reflux disease, gastritis, vomiting, increase in transaminases Musculoskeletal: increase in creatine phosphokinase (CPK), increased muscle tone and cramping, myalgia. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html © The Swiss Pharmacy

15. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Possible Side Effects Additional, less frequent side effects (less than 2%) reported during the clinical development of Vardenafil Hydrochloride film-coated tablets and Vardenafil orally disintegrating tablets include: Nervous: paresthesia and dysesthesia, somnolence, sleep disorder, syncope, amnesia, seizure Respiratory: dyspnea, sinus congestion Skin and appendages: erythema, rash Ophthalmologic: visual disturbance, ocular hyperemia, visual color distortions, eye pain and eye discomfort, photophobia, increase in intraocular pressure, conjunctivitis. Urogenital: increase in erection, priapism URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html © The Swiss Pharmacy

16. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Valif Oral Jelly Overdosage The maximum dose of Vardenafil Hydrochloride (Valif Oral Jelly) for which human data are available is a single 120 mg dose administered to healthy male volunteers. The majority of these subjects experienced reversible back pain/myalgia and/or “abnormal vision.” Single doses up to 80 mg vardenafil and multiple doses up to 40mg vardenafil administered once daily over 4 weeks were tolerated without producing serious adverse side effects. When 40 mg of Vardenafil was administered twice daily, cases of severe back pain were observed. No muscle or neurological toxicity was identified. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html © The Swiss Pharmacy

17. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Treatment of Valif Oral Jelly Overdosage In cases of Vardenafil Hydrochloride (Valif Oral Jelly) overdose, standard supportive measures should be taken as necessary. Renal dialysis is not expected to accelerate clearance as Vardenafil is highly bound to plasma proteins and not significantly eliminated in the urine. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html © The Swiss Pharmacy

18. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Valif Oral Jelly During Pregnancy Vardenafil Hydrochloride (Valif Oral Jelly) has been classified by the US FDA as Pregnancy Category B. Vardenafil hydrochloride is not indicated for use in women. There are no studies of Vardenafil Hydrochloride (Valif Oral Jelly) use in pregnant women. No evidence of specific potential for teratogenicity, embryotoxicity or fetotoxicity was observed in rats and rabbits that received Vardenafil at up to 18 mg/kg/day during organogenesis. This dose is approximately 100 fold (rat) and 29 fold (rabbit) greater than the AUC values for unbound Vardenafil and its major metabolite in humans given the maximum recommended human dose (MRHD) of 20 mg. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html © The Swiss Pharmacy

19. Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) Valif Oral Jelly Valif Oral Jelly (Generic Vardenafil Hydrochloride Trihydrate Jelly) is manufactured by Ajanta Pharma Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html https://www.theswisspharmacy.com/product_info.php?info=p9801_Vardenafil-Oral-Jelly.html © The Swiss Pharmacy