Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets)

1. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) © The Swiss Pharmacy

2. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Zinetac (Generic Ranitidine Hydrochloride tablets) relieves heartburn associated with acid indigestion and sour stomach. This medicine also prevents heartburn associated with acid indigestion and sour stomach brought on by certain foods and beverages. This medicine is also used for the treatment of gastroesophageal reflux disease (GERD) in patients with less severe GERD. © The Swiss Pharmacy

3. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) © The Swiss Pharmacy

4. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Zinetac Tablets are manufactured by GlaxoSmithKline Pharmaceuticals Limited, India in the strengths of 150 mg and 300 mg. © The Swiss Pharmacy

5. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Chemical Structure © The Swiss Pharmacy

6. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) The active ingredient contained in Zinetac tablets is Ranitidine Hydrochloride. Each Zinetac tablet contains Ranitidine Hydrochloride equivalent to 150 mg or 300 mg of Ranitidine. © The Swiss Pharmacy

7. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Uses of Zinetac 150mg and 300mg Tablets: Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) is used to treat ulcers of the stomach and intestines and prevent them from coming back after they have healed. This medication is also used to treat certain stomach and throat (esophagus) problems (such as erosive esophagitis, gastroesophageal reflux disease-GERD, Zollinger- Ellison syndrome). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as cough that doesn't go away, stomach pain, heartburn, and difficulty swallowing. Ranitidine belongs to a class of drugs known as H2 blockers. This medication is also available without a prescription. It is used to prevent and treat heartburn and other symptoms caused by too much acid in the stomach (acid indigestion). URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html © The Swiss Pharmacy

8. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Uses of Zinetac 150mg and 300mg Tablets: Zinetac (Generic Ranitidine tablets) are used for the treatment of duodenal ulcer and benign gastric ulcer, including that associated with non-steroidal anti-inflammatory agents. They are also used for the following: Treatment of duodenal ulcers associated with Helicobacter pylori infection. Treatment of post-operative ulcer Zollinger-Ellison syndrome Oesophageal reflux disease Chronic episodic dyspepsia, characterised by pain (epigastric or retrosternal) which is related to meals or disturbs sleep but is not associated with the preceding conditions may benefit from Ranitidine Hydrochloride treatment. © The Swiss Pharmacy

9. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Uses of Zinetac 150mg and 300mg Tablets: Zinetac Tablets are indicated for the following conditions where reduction of gastric secretion and acid output is desirable: prophylaxis of gastrointestinal haemorrhage from stress ulceration in seriously ill patients prophylaxis of recurrent haemorrhage in patients with bleeding peptic ulcers before general anaesthesia in patients considered to be at risk of acid aspiration (Mendelson's syndrome), particularly obstetric patients during labour. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html © The Swiss Pharmacy

10. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Recommended Adult Dosage The recommended adult oral dosage of Zinetac Tablets Ranitidine tablets) for duodenal ulcer is 150 mg twice daily. An alternative dosage of 300 mg once daily after the evening meal or at bedtime can be used for patients in whom dosing convenience is important. The recommended adult dosage for maintenance of healing of duodenal ulcers is 150 mg at bedtime. The recommended adult dosage for pathological hypersecretory conditions (such as Zollinger-Ellison syndrome) is 150 mg twice a day. Zinetac Tablets (Generic URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html © The Swiss Pharmacy

11. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Recommended Adult Dosage GERD: The current recommended adult oral dosage is 150 mg twice a day. Erosive Esophagitis: The current recommended adult oral dosage is 150 mg four times a day. Maintenance of Healing of Erosive Esophagitis: The current recommended adult oral dosage is 150 mg twice a day. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html © The Swiss Pharmacy

12. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Contraindications ➔Zinetac is contraindicated in patients with a known hypersensitivity to Ranitidine Hydrochloride or any component of the tablet. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html © The Swiss Pharmacy

13. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Storage Instructions Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html © The Swiss Pharmacy

14. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Warnings The possibility of malignancy should be excluded before commencement of therapy in patients with gastric ulcer and in patients of middle age and over with new or recently changed dyspeptic symptoms as treatment with Ranitidine may mask symptoms of gastric carcinoma. Ranitidine is excreted via the kidney and so plasma levels of the medication are increased in patients with renal impairment. The dose should be adjusted in patients with renal impairment. Regular supervision of patients who are taking non-steroidal anti- inflammatory drugs concomitantly with Zinetac tablets is recommended, especially in the elderly. Current evidence shows that ranitidine protects against NSAID associated ulceration in the duodenum and not in the stomach. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html © The Swiss Pharmacy

15. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Warnings Rare reports suggest that Ranitidine Hydrochloride may precipitate acute porphyric attacks in patients with acute porphyria. Zinetac tablets should therefore be avoided in patients with a history of acute porphyria. In patients such as the elderly, persons with chronic lung disease, diabetes or the immunocompromised, there may be an increased risk of developing community acquired pneumonia. The prolonged use of H2-receptor antagonists, may impair the absorption of protein-bound Vitamin B12 and may contribute to the development of Cyanocobalamin (vitamin B12) deficiency. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html © The Swiss Pharmacy

16. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Zinetac Tablets and Alcohol It is best not to mix Zantac and alcohol. It is possible for most people to take Zantac with small amounts of alcohol safely, but it could be dangerous. The dangers of mixing Zinetac and alcohol include increased effect of alcohol. However, avoid consuming alcohol as it is known to increase acidity and can make your acidity worse. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html © The Swiss Pharmacy

17. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Possible Side Effects The following side effects have been reported as events in clinical trials or in the routine management of patients treated with Ranitidine Hydrochloride (Zinetac tablets). Central nervous system: Rarely, malaise, dizziness, somnolence, insomnia and vertigo. Rare cases of reversible mental confusion, depression and hallucinations have been reported, predominantly in severely ill and elderly patients. In addition reversible involuntary movement disorders have been reported rarely. There have been a few reports of reversible blurred vision suggestive of a change in accommodation. Reversible impotence has been reported rarely. Cardiovascular: As with other H2-receptor antagonists, rare reports of tachycardia, bradycardia, premature ventricular beats, atrioventricular block and asystole. Gastrointestinal: Constipation, diarrhoea, nausea/vomiting, abdominal discomfort/pain. © The Swiss Pharmacy

18. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Possible Side Effects Hepatic: Transient and reversible changes in liver-function tests can occur. There have been occasional reports of hepatitis, hepatocellular or hepatocanalicular or mixed, with or without jaundice. These were usually reversible. Renal: Very rare cases of acute interstitial nephritis have been reported. Musculoskeletal: Rare reports of arthralgias and myalgia. Haematological: Rare reports of agranulocytosis or pancytopenia, sometimes with marrow hypoplasia or aplasia, have been reported. Blood count changes (leucopenia, thrombocytopenia) have occurred in a few patients. These are usually reversible. Dermatological: Rash, including rare cases of mild erythema multiforme. Rare cases of vasculitis and alopecia have been reported. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html © The Swiss Pharmacy

19. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Possible Side Effects Endocrine: Controlled studies in animals and humans have shown no stimulation of any pituitary hormone by Ranitidine (Zinetac tablets), no antiandrogenic activity, and cimetidine induced gynaecomastia and impotence in hypersecretory patients have resolved when ranitidine was substituted. However, occasional cases of breast conditions such as gynaecomastia and galactorrheoa, impotence and loss of libido have been reported in male patients receiving Ranitidine, but the incidence did not differ from that in the general population. Other: Rare cases of hypersensitivity reactions (e.g. fever, bronchospasm, anaphylactic shock, rash, eosinophilia, urticaria, angioneurotic oedema, hypotension, chest pain, rash, eosinophilia), small increases in serum creatinine. Acute pancreatitis has been reported rarely. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html © The Swiss Pharmacy

20. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Zinetac Tablets Overdosage There has been limited experience with Ranitidine Hydrochloride (Zinetac tablets) overdosage. Reported acute ingestions of up to 18 g orally have been associated with transient adverse effects similar to those encountered in normal clinical experience. In addition, abnormalities of gait and hypotension have been reported. When overdosage occurs, the usual measures to remove unabsorbed material from the gastrointestinal tract, clinical monitoring, and supportive therapy should be employed. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html © The Swiss Pharmacy

21. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Zinetac Tablets During Pregnancy Ranitidine Hydrochloride (Zinetac tablets) has been classified by the US FDA as Pregnancy Category B. Reproduction studies have been performed in rats and rabbits at oral doses up to 160 times the human oral dose and have revealed no evidence of impaired fertility or harm to the fetus due to Ranitidine. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this medicine should be used during pregnancy only if clearly needed. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html © The Swiss Pharmacy

22. Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) Zinetac Tablets Zinetac Tablets (Generic Ranitidine Hydrochloride Tablets) are manufactured by GlaxoSmithKline Pharmaceuticals Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9628_Ranitidine-Hydrochloride-Tablets.html © The Swiss Pharmacy