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Common dental frustrations and how to overcome them u2013 part two
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Common dental frustrations and how to overcome them: The older animal with concurrent periodontal disease Rachel Perry BSc, BVM&S, MANZCVS, Dipl.EVDC, MRCVS European Veterinary Specialist EBVS®, Dentistry RCVS Specialist, Veterinary Dentistry
“All old dogs and cats have bad breath” • It can be easy for both clients and veterinary professionals to normalise disease
“All old dogs and cats have bad breath” • Halitosis is not normal and is one of the first signs of disease. • Halitosis is caused by release of volatile sulphur compounds (VSC’s) released by certain periodontal pathogens in plaque • Include hydrogen sulphide and methyl mercaptan
Volatile Sulphur Compounds (VSC) • Negative effects include: • Toxic effect on epithelial cells, fibroblasts, collagen • Stimulation of osteoclasts • Therefore involved in initiation and propagation of periodontal disease Milella LM. J Vet Dent 2015; 32 (2): 99-102
Plaque • Bacteria in the mouth form a biofilm • Many hundreds of species present Davis IJ, Wallis C, Deusch O, Colyer A, Milella L, et al. (2013) A Cross-Sectional Survey of Bacterial Species in Plaque from Client Owned Dogs with Healthy Gingiva, Gingivitis or Mild Periodontitis. PLOS ONE 8(12): e83158. https://doi.org/10.1371/journal.pone.0083158 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083158
Table 1. Bacterial phyla identified in canine subgingival plaque. Dewhirst FE, Klein EA, Thompson EC, Blanton JM, Chen T, et al. (2012) The Canine Oral Microbiome. PLOS ONE 7(4): e36067. https://doi.org/10.1371/journal.pone.0036067 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036067
Bacterial shift in disease: dogs • Shift towards and anaerobic population in disease • Shift towards a Gram positive population in disease Figure 4. Proportions of Gram positive OTUs for each sample by health status; health (green), gingivitis (orange) and mild periodontitis (red). Davis IJ, Wallis C, Deusch O, Colyer A, Milella L, et al. (2013) A Cross-Sectional Survey of Bacterial Species in Plaque from Client Owned Dogs with Healthy Gingiva, Gingivitis or Mild Periodontitis. PLOS ONE 8(12): e83158. https://doi.org/10.1371/journal.pone.0083158 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083158
Figure 2. Average proportions with 95% confidence intervals for OTUs with a significant health status effect; health (green), gingivitis (orange) and mild periodontitis (red). Davis IJ, Wallis C, Deusch O, Colyer A, Milella L, et al. (2013) A Cross-Sectional Survey of Bacterial Species in Plaque from Client Owned Dogs with Healthy Gingiva, Gingivitis or Mild Periodontitis. PLOS ONE 8(12): e83158. https://doi.org/10.1371/journal.pone.0083158 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083158
Figure 5. Proportions of A) aerobes & B) anaerobes for each sample by health status; health (green), gingivitis (orange) and mild periodontitis (red). Davis IJ, Wallis C, Deusch O, Colyer A, Milella L, et al. (2013) A Cross-Sectional Survey of Bacterial Species in Plaque from Client Owned Dogs with Healthy Gingiva, Gingivitis or Mild Periodontitis. PLOS ONE 8(12): e83158. https://doi.org/10.1371/journal.pone.0083158 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083158
Bacterial shift in disease: cats • Shift towards and anaerobic population in disease • Shift towards a Gram positive population in disease • Different from situation in the human oral cavity where more Gram negative species associated with disease
Fig 7. Percentage abundance of Gram positive OTUs for each sample by health status; health (green), gingivitis (yellow), mild periodontitis (red). Harris S, Croft J, O’Flynn C, Deusch O, Colyer A, et al. (2015) A Pyrosequencing Investigation of Differences in the Feline Subgingival Microbiota in Health, Gingivitis and Mild Periodontitis. PLOS ONE 10(11): e0136986. https://doi.org/10.1371/journal.pone.0136986 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136986
Fig 8. Percentage abundance of A) aerobes, B) anaerobes and C) facultative anaerobes for each sample by health status; health (green), gingivitis (yellow), mild periodontitis (red). Harris S, Croft J, O’Flynn C, Deusch O, Colyer A, et al. (2015) A Pyrosequencing Investigation of Differences in the Feline Subgingival Microbiota in Health, Gingivitis and Mild Periodontitis. PLOS ONE 10(11): e0136986. https://doi.org/10.1371/journal.pone.0136986 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136986
Calculus (tartar) • Mineralised plaque bacteria • The plaque is responsible for the disease, not calculus • Therefore do not judge the level of disease simply by judging calculus levels Calculus level disease level!
“All old dogs and cats slow up” • This perceived ‘slowing up’ may be due to the constant bacteraemia from periodontal disease
Periodontal disease associations • Chronic kidney disease in the cat (CKD) • Retrospective cohort study of > 50 000 cats showed an increased risk of CKD with presence of periodontal disease • Risk greatest for stage 3 & 4 periodontal disease Trevejoet al.J Am Vet Med Assoc2018;252:710–720 Finch et al. J Vet Intern Med 2016;30:602–610
Periodontal disease and CKD: cats • Earlier mortality for cats with stages 2, 3 & 4 periodontal disease Trevejoet al. J Am Vet Med Assoc2018;252:710–720
Periodontal disease/CKD association: dogs • Retrospective longitudinal cohort study of >160000 dogs • Hazard ratio for azotaemic CKD increased with severity of periodontal disease • Stage 1 hazard ratio= 1.8 • Stage 2 hazard ratio= 2.0 • Stage 3 and 4 hazard ratio= 2.7 Glickman et al. Preventive Veterinary Medicine 99 (2011) 193–200
Periodontal disease education • Take photographs- show client on tablet • Draw pictures • Waiting room posters • Practice leaflets • Commercial guides • Email oralcare@vbd.co.uk
Summary • Periodontal disease is more common in older animals but should not be normalised. • Mounting evidence has demonstrated associations with systemic diseases such as chronic kidney disease. • Identify and treat any co-morbidities and address the dental problems detected.