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Looking for antidepression and anti anxiety medicines at best prices then one must checkout at Xrite Pharmacy. Xritepharmacy.com is one of USAu2019s most trusted pharmacies, with over many yearsu2019 experience in dispensing quality medicines. One can find all kind of medicines and drugs at best prices at our store. Once your order has been successfully placed or payment has been made, you will receive an email confirmation. The email will include your order number and shipping method which will depend on your location.<br>Ensure your shipping address is correct as we will not be able to redirect goods once they are en route to you.<br><br>Address: 1400 NW 65th St, Fort Lauderdale, FL 33309, USA<br><br>Telephone: 1(817)4871442<br><br>E-mail: sales@xritepharmacy.com<br><br>Website: https://xritepharmacy.com<br>
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ANTIDEPRESSANTS “No Worry Of Prescription, Get Your Medicines At Your Door” Visit:www. xritepharmacy.com
DEPRESSION • Types • Symptoms • Diagnosis • Causes • Treatment For Best Drug Website Online checkout Xrite Pharmacy
TYPES OF DEPRESSION • Major depression • Chronic depression (Dysthymia) • Atypical depression • Bipolar disorder/Manic depression • Seasonal depression (SAD)
SYMPTOMS • persistently sad, anxious, or empty moods • loss of pleasure in usual activities (anhedonia) • feelings of helplessness, guilt, or worthlessness • crying, hopelessness, or persistent pessimism • fatigue or decreased energy • loss of memory, concentration, or decision-making capability • restlessness, irritability • sleep disturbances • change in appetite or weight • physical symptoms that defy diagnosis and do not respond to treatment (especially pain and gastrointestinal complaints) • thoughts of suicide or death, or suicide attempts • poor self-image or self-esteem (as illustrated, for example, by verbal self-reproach)
DIAGNOSIS • Extensive patient and family history • Blood test for hypothyroidism • Current medication • DSM-IV • One of the first two symptoms • Five other symptoms
CAUSES OF DEPRESSION • Genetics • Death/Abuse • Medications Find Antidepression & Anti Anxiety Medicines At Best Prices At Xrite Pharmacy
TREATMENT FOR DEPRESSION • Psychotherapy • Electroconvulsive therapy • Natural alternatives • Medication • SSRIs • MAOIs • TCAs • SNRIs • NDRIs • TeCAs
NEUROTRANSMITTERS AND THE CATECHOLAMINE HYPOTHESIS • Neurotransmitters pass along signal • Smaller amount of neurotransmitters causes depression
MONOAMINE OXIDASE (MAO) AND DEPRESSION • MAO catalyze deamination of intracellular monoamines • MAO-A oxidizes epinephrine, norepinephrine, serotonin • MAO-B oxidizes phenylethylamine • Both oxidize dopamine nonpreferentially • MAO transporters reuptake extracellular monoamine
MONOAMINE OXIDASE INHIBITORS (MAOIS) • History • Isoniazid • Iproniazid • Current Drugs • Mechanism of Action • Side Effects Isoniazid Iproniazid
MAOIS ON THE MARKET • MAO Inhibitors (nonselective) • Phenelzine (Nardil) • Tranylcypromine (Parnate) • Isocarboxazid (Marplan) • MAO-B Inhibitors (selective for MAO-B) • Selegiline (Emsam)
MAOIS MECHANISM OF ACTION • MAO contains a cysteinyl-linked flavin • MAOIs covalently bind to N-5 of the flavin residue of the enzyme
THE RECEPTOR SENSITIVITY HYPOTHESIS • Supersensitivity and up-regulation of post-synaptic receptors leads to depression • Suicidal and depressed patients have increased 5HT-α2 receptors
TRICYCLIC ANTIDEPRESSANTS (TCAS) • History • Imipramine • Current Drugs • Mechanism of Action • Side Effects Imipramine
TCAS ON THE MARKET • Amitriptyline • Desipramine (Norpramin) • Doxepin (Sinequan) • Imipramine (Tofranil, Tofranil-PM) • Nortriptyline (Pamelor) • Protriptyline (Vivactil) • Trimipramine (Surmontil)
TCAS MECHANISM OF ACTION • TCAs inhibit serotonin, norepinephrine, and dopamine transporters, slowing reuptake • TCAs also allow for the downregulation of post-synaptic receptors • All TCAs and SSRIs contain an essential amino group that appears to interact with Asp-98 in hSERT
TETRACYCLIC ANTIDEPRESSANTS (TECAS) • Current Drugs • Mirtazapine (Remeron) • Mechanism of Action • Same as TCAs • Side Effects
SELECTIVE SEROTONIN REUPTAKE INHIBITORS • Most commonly prescribed class • Current drugs • Mechanism of action • Side effects Serotonin
SSRIS ON THE MARKET • citalopram (Celexa) • dapoxetine (Priligy) • escitalopram (Lexapro) • fluoxetine (Prozac) • fluvoxamine (Luvox) • paroxetine (Paxil) • sertraline (Zoloft) • zimelidine (Zelmid) (discontinued) • indalpine (Upstene) (discontinued) Fluoxetine 1:1 Sertraline
SSRIS MECHANISM OF ACTION • Exact mechanism remains uncertain • Ser-438 residue in the human serotonin transporter (hSERT) appears to be a determining factor in SSRI potency • Antidepressants interact directly with hSERT
SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIS) • Slightly greater efficacy than SSRIs • Slightly fewer adverse effects than SSRIs • Current drugs • Venlafaxine (Effexor) • Duloxetine (Cymbalta) • Mechanism of Action • Very similar to SSRIs • Works on both neurotransmitters • Side effects • Similar to SSRIs • Suicide Venlafaxine 1:1 Duloxetine
NOREPINEPHRINE-DOPAMINE REUPTAKE INHIBITORS (NDRIS) • Current drugs • Bupropion (Wellbutrin) • Mechanims of Action • Similar to SSRIs and SNRIs • More potent in inhibiting dopamine • Also anα3-β4 nicotinic antagonist • Adverse effects • Lowers seizure threshold • Suicide • Does not cause weight gain or sexual dysfunction (even used to treat the two) Bupropion 1:1
Who We Are? Xritepharmacy.com is one of USA’s most trusted pharmacies, with over many years’ experience in dispensing quality medicines. At Xritepharmacy.com, we help you look after your own health effortlessly as well as take care of loved ones wherever they may reside in USA. You can buy and send medicines from any corner of the country - with just a few clicks of the mouse. Find Online Tablets For Depression At Xrite Pharmacy At Best Prices
Thank You!! XritePharmacy 1400 NW 65th St, Fort Lauderdale, FL 33309,USA Visit: www.xritepharmacy.com