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U78-5672 ID:434500-5

U78-5672 ID:434500-5. A 4-year-old girl had persistent hematuria (microscopic) found by routine urinalysis. Patient has been symptom free. Been investigated with no good information revealed. Probable diagnosis Focal glomerulonephritis. IF. IgG –Negative. IgA –Negative. IgM –Negative.

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U78-5672 ID:434500-5

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  1. U78-5672ID:434500-5 A 4-year-old girl had persistent hematuria (microscopic) found by routine urinalysis. Patient has been symptom free. Been investigated with no good information revealed. Probable diagnosis Focal glomerulonephritis.

  2. IF • IgG –Negative. • IgA –Negative. • IgM –Negative. • C3 –Negative. • Fibrinogen –Negative.

  3. Interpretation • The minimal findings are compatible with “idiopathic (essential) hematuria” or with “benign familial hematuria”. • Persistent “fetal type glomeruli” are a feature of early cases of “Alport’s syndrome”, these can be seen in infantile kidneys with persistent fetal lobulation of the cortex. • The absence of focal proliferative changes in glomeruli mitigates against a diagnosis of focal glomerulonephritis.

  4. DIAGNOSIS • Needle biopsy of kidney showing a few persistent “fetal Glomeruli” renal glomeruli and occasional red cell casts within renal tubules.

  5. EM82-5343 Glomerulonephritis (open renal biopsy).

  6. IF • IgG – Negative. • IgA – Negative. • IgM – Negative. • C3 – Negative. • Properdin – Negative.

  7. DIAGNOSIS • Probable “Progressive Hereditary Nephritis” (Alport’s syndrome).

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