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2Na

2K. 2K. Na. Na. Na. ATP. 3Na. Ca. 2Na. Ca. H. Na. H. Cyt. 3Na. ATP. ATP. NCX. Sarcolemma. Na. Ca. Ca. PLB. RyR. ATP. I Ca. SR. Ca. Ca. [Ca] i. NCX. AP (E m ). T-Tubule. 3Na. Contraction. by D.M. Bers. 2K. Na. Na. Na. ATP. 3Na. Ca. 2Na. Ca. H. Na. H.

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2Na

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  1. 2K 2K Na Na Na ATP 3Na Ca 2Na Ca H Na H Cyt 3Na ATP ATP NCX Sarcolemma Na Ca Ca PLB RyR ATP ICa SR Ca Ca [Ca]i NCX AP (Em) T-Tubule 3Na Contraction by D.M. Bers

  2. 2K Na Na Na ATP 3Na Ca 2Na Ca H Na H Cyt 3Na ATP NCX Sarcolemma Na Ca Ca PLB RyR ATP ICa SR Ca Ca [Ca]i NCX AP (Em) T-Tubule 3Na Contraction by D.M. Bers

  3. 2K 2K Na Na Na ATP 3Na Ca 2Na Ca H Na H Cyt 3Na ATP ATP NCX Sarcolemma Na Ca Ca PLB RyR ATP ICa SR Ca Ca [Ca]i NCX AP (Em) T-Tubule 3Na Contraction by D.M. Bers

  4. Ventricular Myocyte 2K Na ATP PLM K Cl 3Na ATP PLB Ca Cyt 2Na H H Ca Na 3Na ATP Na- CaX Sarcolemma Ca Ca Ca RyR ICa SR Ca Ca Ca Myofil Ca Na- CaX 3Na T-Tubule Mito by D.M. Bers

  5. Crossbridge Cycle Chemical steps & Physical steps correlate http://www.sci.sdsu.edu/movies/actin_myosin.html

  6. Crossbridge Cycle Chemical steps & Physical steps correlate http://www.sci.sdsu.edu/movies/actin_myosin.html

  7. Smooth Muscle EC-Coupling Pharmaco-electrical coupling or inhibited K channel Electro-mechanical coupling ICa driven APs or Ca entry & Depol ICa can occur during tonic depol. at -50 to -15 mV and [Ca]i elevation via store-operated Ca channels Phasic IP3- & SR-dependent Tonic Ca2+ influx-dependent (store operated Ca entry) DAG-PKC Pharmaco-mechanical Coupling

  8. Smooth Muscle EC-Coupling Many agents work via cGMP & cAMP cGMP stimulates MLC dephosporylation relaxation cAMP stimulates SR Ca uptake, spontaneous local Ca release (Ca sparks) & Ca-activated K current hyperpolarization & relaxation RyR IK(Ca) Pharmaco-electrical coupling Electro-mechanical coupling Ca entry & Depol Pharmaco-mechanical Coupling

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