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Figure 3. Student poster session at UCSB Summer School.

Multifunctional polypeptide drug delivery vehicles Timothy J. Deming, University of California-Los Angeles, DMR 0907453. Our project is currently focused on minimizing the cytotoxicity of polypeptide vesicles for use as drug carriers.

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Figure 3. Student poster session at UCSB Summer School.

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  1. Multifunctional polypeptide drug delivery vehiclesTimothy J. Deming, University of California-Los Angeles, DMR 0907453 Our project is currently focused on minimizing the cytotoxicity of polypeptide vesicles for use as drug carriers. We examined how varying the hydrophobic leucine segment length affects vesicle toxicity to human cervical cancer cells (Figure 1) and found that polypeptides with at least 20 leucine residues show minimal toxicity. Figure 1. Viability of human cervical cancer cells after a 5 hour incubation with unextruded polypeptide vesicles of different leucine length. To further lower toxicity, we have prepared vesicles using triblock copolymers (Figure 2), where an excess of anionic residues reduces cell toxicity and cationic residues for cell uptake should be presented on the vesicle surface. Figure 2 Drawings to show mixing of copolypeptides to add functionality to membranes. Left: E60L20. Right: E60L20 and R10E80L20 mixture to present oligoarginine on the membrane surface. Red = L; Blue = E; Green = R.

  2. Multifunctional polypeptide drug delivery vehiclesTimothy J. Deming, University of California-Los Angeles, DMR 0907453 Prof. Deming and April Rodriguez, a Ph.D. student working on this project, participated in the NSF IGERT sponsored Summer School on Preparative Strategies in Solid State and Materials Chemistry at UCSB in August 2010; and Prof. Deming also lectured on “Engineering Better Medicines” to over 600 engineering students at the NAE Grand Challenges Summit Series in Raleigh, NC in March 2010. Prof. Kamei performed his yearly outreach activity at Mark Keppel High School, his alma mater, in November 2009. He will again be visiting this high school in November 2010. Howard Dai and Sophia Lin, who were undergraduate researchers working on this project, will be attending the MD program at Texas A&M and the PhD chemical engineering program at UC Irvine, respectively, starting this academic year. Figure 3. Student poster session at UCSB Summer School.

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