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Figure S1 (Supplemental Material). 1 50 SINAT1 (1) --------MAPGGSALKEALE-----SNSTGVDYEVKMAKVEANS-KPTK SINAT2 (1) --------MAPGGSALKEVME-----SNSTGMDYEVKTAKVEVNNNKPTK

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  1. Figure S1 (Supplemental Material) 1 50 SINAT1 (1) --------MAPGGSALKEALE-----SNSTGVDYEVKMAKVEANS-KPTK SINAT2 (1) --------MAPGGSALKEVME-----SNSTGMDYEVKTAKVEVNNNKPTK SINAT3 (1) --------MDLDSMDCTSTMDVT-DDEEIHQDRHSYASVSKHHHT-NNNT SINAT4 (1) --------METDSMECVSSTGNEIHQNGNGHQSYQFSSTKTHGGA-AAAA SINAT5 (1) --------METDSIDSVIDD-------DEIHQKHQFSSTKSQGG------ SIAH (1) --------------------------------MSRQTATALPTGTSKCPP SINA (1) MSNKINPKRREPTAAAAGAGATGVATNTSTSTGSSSAGNTSSANTSSSSS Consensus (1) M S Y AS K A T 51 ▼ ▼ ▼ ▼ ▼ ▼100 SINAT1 (37) SGSGSIGKF--HSSNGVYELLECPVCTNLMYPPIHQCPNGHTLCSSCKLR SINAT2 (38) PGSAGIGKYGIHSNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNCKLR SINAT3 (41) TNVNAAASGLLPTTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKAR SINAT4 (42) VVTNIVGPTATAPATSVYELLECPVCTYSMYPPIHQCHNGHTLCSTCKVR SINAT5 (30) ------ATVVISPATSVYELLECPVCTNSMYPPIHQCHNGHTLCSTCKSR SIAH (19) SQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPK SINA (51) SSLSSAGGGDAGMSADLTSLFECPVCFDYVLPPILQCSSGHLVCVSCRSK Consensus (51) S G SA VYELLECPVCTN MYPPIHQC NGHTLCSTCK R 101 ▼ ▼ ▼ ▼ 150▼ SINAT1 (85) VQNTCPTCRYELGNIRCLALEKVAESLEVPCRYQNLGCQDIFPYYSKLKH SINAT2 (88) VQNTCPTCRYELGNIRCLALEKVAESLEVPCRYQNLGCHDIFPYYSKLKH SINAT3 (91) VHNRCPTCRQELGDIRCLALEKVAESLELPCKHMSLGCPEIFPYYSKLKH SINAT4 (92) VHNRCPTCRQELGDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKH SINAT5 (74) VHNRCPTCRQELGDIRCLALEKVAESLELPCKYYNLGCLGIFPYYSKLKH SIAH (69) L-TCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADH SINA (101) L-TCCPTCRGPLANIRNLAMEKVASNVKFPCKHSGYGCTASLVYTEKTEH Consensus (101) V N CPTCR ELG IRCLALEKVAESLELPCKY NLGC DIFPYYSKLKH 151▼ ▼ ▼ ▼ ▼ 200 SINAT1 (135) EQHCRFRSYSCPYAGSECSVTGDIPTLVDHLKDDHKVDMHDGCTFNHRYV SINAT2 (138) EQHCRFRPYTCPYAGSECSVTGDIPTLVVHLKDDHKVDMHDGCTFNHRYV SINAT3 (141) ETVCNFRPYSCPYAGSECSVTGDIPFLVAHLRDDHKVDMHSGCTFNHRYV SINAT4 (142) ESLCNFRPYSCPYAGSECGIVGDIPFLVAHLRDDHKVDMHAGSTFNHRYV SINAT5 (124) ESQCNFRPYSCPYAGSECAAVGDITFLVAHLRDDHKVDMHTGCTFNHRYV SIAH (118) EELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHK-SITTLQGEDIVFL SINA (150) EETCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHK-SITTLQGEDIVFL Consensus (151) E C FRPYSCPYAGSECSV GDIP LV HLRDDHKVDMHTGCTFNHRYV 201 250 SINAT1 (185) KSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFMGDEN SINAT2 (188) KSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFMGDEN SINAT3 (191) KSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGMAPVYMAFLRFMGDET SINAT4 (192) KSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGMGPVYMAFLRFMGDEE SINAT5 (174) KSNPREVENATWMLTVFQCFGQYFCLHFEAFQLGMAPVYMAFLRFMGDED SIAH (167) ATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRK SINA (199) ATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRK Consensus (201) KSNP EVENATWMLTVF CFG YFCLHFEAFQLGMAPVYMAFLRFMGDE 251 300 SINAT1 (235) EAKKFSYSLEVGAHSRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALY SINAT2 (238) EAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALY SINAT3 (241) EARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSHDGLIIQRNMALF SINAT4 (242) DARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMALF SINAT5 (224) DARNYTYSLEVGGSGRKQTWEGTPRSVRDSHRKVRDSHDGLIIQRNMALF SIAH (217) QAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQL SINA (249) EAENFVYRLELNGNRRRLTWEAMPRSIHEGVASAIHNSDCLVFDTSIAQL Consensus (251) EARNFSYSLEVGGHGRKLTWEGTPRSIRDSHRKVRDS DGLII RNMALF 301 338 SINAT1 (285) FSGSDKEELKLRVTGRIWKEE----------------- SINAT2 (288) FSGGDRQELKLRVTGRIWKEE----------------- SINAT3 (291) FSGGDRKELKLRVTGRIWKEQQQSGEGGGACIPNLS-- SINAT4 (292) FSGGDRKELKLRVTGKIWKEQHSP--DSGLSIPNLSSS SINAT5 (274) FSGGDKKELKLRVTGRIWKEQQNP--DSGVCITSMCSS SIAH (267) FAENGNLGINVTISMC---------------------- SINA (299) FADNGNLGINVTISLV---------------------- Consensus (301) FSGGDR ELKLRVTGRIWKE

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