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Notable Patents

Notable Patents. Coronary Heart Disease: KIF 6 7,799,530 – Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof

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Notable Patents

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  1. Notable Patents • Coronary Heart Disease: • KIF6 • 7,799,530 – Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof • 7,695,916 - Genetic polymorphisms associated with cardiovascular disorders and drug reponse, methods of detection and uses thereof • LPA • 7,781,168 - Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof • Cancer: • Breast cancer: 7,695,915 - a molecular prognostic signature for predicting breast cancer metastasis, and uses thereof • Cancer targets: • Lung: 7,807,392 and 7,521,195 - Lung disease targets and uses thereof • Colon: 7,776,555 and 7,842,466– Colon disease targets and uses thereof • Kidney: 7,611,703 and 7,608,413 - Kidney disease targets and uses thereof • Pancreatic: 7,473,531 and 7,358,231 - Pancreatic disease targets and uses thereof • Breast: 7,842,467 - Breast disease targets and uses thereof Celera holds numerous United States and foreign patents based on its discoveries. Listed below are United States patents covering notable discoveries in select disease areas: 1

  2. Notable Patents • Autoimmune Disease: • Rheumatoid Arthritis: • PTPN22: 7,833,706 - Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof • TRIP: 7,811,794 - Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof • TRAF1: 7,863,021 - Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof • Liver Disease: • TLR4: 7,820,380 - Genetic polymorphisms associated with liver fibrosis in hepatitis c virus-infected subjects, methods of detection and uses thereof • AZIN1: 7,727,725 - Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof • Neurodegenerative Disease: • DAPK: 7,695,911 - Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof • NEDD9: 7,816,083 - Genetic polymorphisms associated with neurodegenerative diseases, methods of detection and uses thereof • GALP: 7,651,840 - Genetic polymorphisms associated with Alzheimer's disease, methods of detection and uses thereof • Small Molecules: • Cathespin K inhibitor (licensed to Merck): 7,375,134 - Cathepsin cysteine protease inhibitors 2

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