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Modulation of Multidrug Resistance in Colorectal Carcinoma by miR-297: Down-Regulating MRP-2

Study on miR-297's role in drug resistance in human colorectal carcinoma by targeting MRP-2, impacting treatment efficacy.

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Modulation of Multidrug Resistance in Colorectal Carcinoma by miR-297: Down-Regulating MRP-2

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  1. miR-297 modulates multidrug resistance in human colorectal carcinoma by down-regulating MRP-2 Ke Xu, Ph.D. Putuo Hospital and Cancer Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China 2016-8-9

  2. Background Colon Cancer: Current Treatments and Preclinical Models for the Discovery and Development of New Therapies

  3. Background Colon Cancer treatment option

  4. Background Comparative Aspects of Molecular Mechanisms of Drug Resistance through ABC Transporters and Other Related Molecules in Canine Lymphoma

  5. Background Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004, 116(2): 281-297

  6. Results Fig. 1 MDR Characteristic of HCT116 and HCT116/L-OHP

  7. Results Fig. 2 MIRNAArarry of HCT116 and HCT116/L-OHP

  8. Results Table The relationship between clinicopathological parameters and miR-297 expression in human coloretal carcinoma Fig. 3 Comparison of miR-297 expression level between human colorectal carcinoma (CRC) and their corresponding nontumorous colon (NC). MiR-297 expression level of NC is set as 1.

  9. Results Fig. 4 Expression levels of miR-297 and MRP-2 in tissue samples

  10. Results Figure 5 MRP-2 is a target of miR-297

  11. Results Figure 6 Modulation of miR-297 expression altered the sensitivity of colorectal cancer cells to anti-cancer drugs

  12. Results Figure 7 Modulation of miR-297 expression altered the MDR of human CRC in vivo

  13. Conclusion Fig. 8 miR-297 modulates multidrug resistance in human colorectal carcinoma by down-regulating MRP-2.

  14. Acknowledgement Putuo Hospital and Cancer Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China Zhongze Fan, M.D. Professor Jianhua Xu, M.D. Professor Qi Li, M.D. Professor East China University of Science and Technology. Xin Liang, Ph.D. Associate Professor. Jianwen Liu, Ph.D. Professor. Shen Ke, Ph.D. student Daling Cui, Ph.D. student YuanhongZheng, Ph.D. student Funding This work was supported by the Shanghai Committee of Science and Technology [grant numbers 11DZ2260600 and 10ZR1427400] and the Ministry of Education of China.

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