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ISOPA review paper – Key points

12/177. ISOPA review paper – Key points. MDI and TDI are not substances of ‘equivalent level of concern’ a nd this can be demonstrated in new toxicological and statistical data

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ISOPA review paper – Key points

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  1. 12/177 ISOPA review paper – Key points • MDI and TDI are not substances of ‘equivalent level of concern’ and this can be demonstrated in new toxicological and statistical data • In its review paper, ISOPA presents a plan for risk management options (RMO) to further reduce the low number of occupational asthma cases caused by diisocyanates MDI and TDI • There are no alternatives to diisocyanates MDI and TDI for the production of polyurethane material and articles

  2. MDI and TDI are no substances of equivalent level of concern • It is possible to set threshold of respiratory sensitisation • In the last decade, there is a decrease in cases of diisocyanate-related asthma incidents • New asthma cases can be eliminated by controls and current exposure standards • The effects are not irreversible: the majority of individuals with diisocyanate-related asthma show improvement or total recovery after removal from exposure

  3. Threshold of respiratory sensitisation • Repeat challenge protocol in the Brown Norway rat has demonstrated thresholds of respiratory sensitisation for the diisocyanate MDI (Pauluhn 2005, 2008 and Pauluhn, Poole, 2011) • Both respiratory irritation and sensitisation may be interdependent, and both irritation and sensitisation by TDI is a threshold phenomenon

  4. Diisocyanates occupational asthma cases • Recent data from several official sources on diisocyanate-related asthma indicates a reduction in the number of cases in the last decade, while the MDI and TDI markets are steadily growing • The Dutch case: • 2000-2004: between none and 5 cases of diisocyanate-related occupational asthma per year reported to the Dutch Centre for Occupational Disease (Dekkers et al 2006) • 2009-2011: none to 4 cases (Nederlands Centrum voorBeroepsziekten, 2012)

  5. Our initiatives to ensure workers’ safety • ISOPA • “Walk the Talk” on the safe use of MDI and TDI for industrial and professional users, and the “Guidelines for loading and unloading of MDI and TDI” • ALIPA – European aliphatic diisocyanate producers association. • Similar product stewardship programmes for HDI and other aliphatic diisocyanates, e.g. “We care that you care”

  6. ISOPA plan for RMO (I) • Spray applications (spray painting and spray insulation) have a higher potential for respiratory sensitisation, predominantly at a professional level • At industry level these operation can be easily carried out in controlled conditions • ISOPA proposes to develop an extended product stewardship plan that focuses on spray applications • In the building and construction industry, as well as in the metal paint industry for both industrial and professional users

  7. ISOPA plan for RMO (II) • In The Netherlands there is guidance on how to apply spray foam indoor and underneath ground floors • ISOPA proposes to make this guidance mandatory and to extend it as following: • Safety training for spray application workers • Mandatory forced ventilation when spraying indoor, before, during and after foaming • Training for all workers on ventilation, machine operation and cleaning of spray foam application to ensure good quality. • Consumer information leaflet, indicating potential smell after applying indoor spray foam • Obligatory certification

  8. No alternatives for MDI and TDI • Polyurethanes cannot be manufactured without the use of aromatic or aliphatic diisocyanates. Therefore, there is no alternative for MDI, TDI, HDI, IPDI and H12MDI, since so far no other chemicals can replace their function in the production of polyurethanes articles

  9. Construction, MDI and HDI , TDI About Polyurethanes Automotive, TDI , MDI, HDI and IPDI Furniture MDI and TDI Appliances, MDI Electronics MDI FootwearMDI and HDI Sports/LeisureMDI, TDI , HDI and IPDI

  10. Socio-economic facts & figures • Socio- Economic Information on the European • Polyurethanes Industry: • Involves more than 23,500 companies most of which are SMEs • Employs more than 817,000 workers • Generates a market value of over €125 billion • Indirect activities involve more than 71,000 companies employing about 2,040,000 people – the majority are SMEs • Data from 2003

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